DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tnc and Dmp1

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	NP_001345942.1	Gene:	Dmp1 / 13406	MGIID:	94910	Length:	503	Species:	Mus musculus

Alignment Length:	667	Identity:	134/667 - (20%)
Similarity:	223/667 - (33%)	Gaps:	238/667 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1474 ATFEPIESEFEVSTKKPAVQGPPLPTLAPAQPEKKPVDAETSTEADISTEPSAEVEKEASGETSE 1538
            |.:...|||............||.||           ::|:|.|:..|.|..|..:..   ::||
Mouse    20 ARYHNTESESSEERTGDLAGSPPPPT-----------NSESSEESQASPEGQANSDHT---DSSE 70

  Fly  1539 SDNEI--------DAGASSTPVPVSADEDKTPSTEKTVEADDKFTTVAPLAGDEEESNLPKLPQD 1595
            |..|:        .||..|......||::    .::....||.|       |||:        .|
Mouse    71 SGEELGYDRGQYRPAGGLSKSTGTGADKE----DDEDDSGDDTF-------GDED--------ND 116

  Fly  1596 IFEEEAPVAVTTAAPSKDDGEQKPVEVEEKPIEDGQKPIEDETSTPTSSENEIEPESDRATTIAP 1660
            :..||.    ....|||.|.:                  ||.|.|..|||:....|:....|.:.
Mouse   117 LGPEEG----QWGGPSKLDSD------------------EDSTDTTQSSEDSTSQENSAQDTPSD 159

  Fly  1661 SKEEPSE------PSTGAPTKDEPAEP-------------------STDAPESDESKETPESEVP 1700
            ||:..||      |..|..|:|..:|.                   ..:..:||:.:.|......
Mouse   160 SKDHDSEDEADSRPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGH 224

  Fly  1701 TTVAPAGEKIPTSSITPDEEPTATSAPVAKPDEDVEKETSTEIPTDAPASSEEDENSSTDQIPSE 1765
            ..::.||  |.:.....|.|||:|                          .:.|::.|.     |
Mouse   225 ARMSSAG--IRSEESKGDHEPTST--------------------------QDSDDSQSV-----E 256

  Fly  1766 VPEKKPETPAQTPEE---GDIVGATAAPTTSDEVPPVQRLPEEVLAEIPQPSTETGIKQQDETTA 1827
            ...:|....:...||   |::..:.:..|.||..                           |.||
Mouse   257 FSSRKSFRRSHVSEEDYRGELTDSNSRETQSDST---------------------------EDTA 294

  Fly  1828 APSIDRKEPYVTEIDEEATTVAPISEKDEKPTEEEKPVEQKPTGEEPSEEEEKEKPIEQDVSTEG 1892
            :....|.|                |::|   |.|.:..|..|.|::||.|..:|
Mouse   295 SKEESRSE----------------SQED---TAESQSQEDSPEGQDPSSESSEE----------- 329

  Fly  1893 PVSTEASEAGSTESSEEVKPSTEGEVAEKPEDKQPSSTAQAPVETIPEISTELPAQDGDKPTSEA 1957
              :.|.|:..|:||.|.|...:.|:        .|.:|:||                ||:..||:
Mouse   330 --AGEPSQESSSESQEGVTSESRGD--------NPDNTSQA----------------GDQEDSES 368

  Fly  1958 PVDSDEDT--------SAPSDEKIPSVSGEEVEGPEVTTASPQAAEEDELKTPAESEPSSTDKVP 2014
               |:||:        |..::|:..|.|.|.:   .::..|.::|::.:    :.|:.....:..
Mouse   369 ---SEEDSLNTFSSSESQSTEEQADSESNESL---SLSEESQESAQDGD----SSSQEGLQSQSA 423

  Fly  2015 ETEYQKPEDETKADETPESVTQVSDVATSTSAPVAGGDIEKDEQATTASPEEEEEIKPTIAPAAE 2079
            .||.:..|.:::.|...|..:...|.:.|          :::..:|.::...||:|:|....|..
Mouse   424 STESRSQESQSEQDSRSEEDSDSQDSSRS----------KEESNSTGSASSSEEDIRPKNMEADS 478

  Fly  2080 ---IPQPSEKEPVDEQE 2093
               |......:|:.:|:
Mouse   479 RKLIVDAYHNKPIGDQD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564
		PHA02664	<433..595	CDD:177447
		Ehrlichia_rpt	529..1065	CDD:118064
		DUF863	<1684..>1788	CDD:283539	18/106 (17%)
		VWC	2762..>2805	CDD:302663
Dmp1	NP_001345942.1	DMP1	1..503	CDD:311295	134/667 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..503		133/664 (20%)
		Cell attachment site. /evidence=ECO:0000255	350..352		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900