DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tnc and LEO1

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	NP_001310832.1	Gene:	LEO1 / 123169	HGNCID:	30401	Length:	688	Species:	Homo sapiens

Alignment Length:	836	Identity:	166/836 - (19%)
Similarity:	298/836 - (35%)	Gaps:	226/836 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1409 DLDKKPE-EDSTKGTEAPESDKVPEVPTSASTENEIEESDKFTTVAPPKISASDETEPTAEE--- 1469
            |.|.:.| :||..|::: :||:......|.::.:|.::.::           .|..:|:.:|
Human    11 DADSEAERKDSDSGSDS-DSDQENAASGSNASGSESDQDER-----------GDSGQPSNKELFG 63

  Fly  1470 DLVPATFEPIESEFEVSTKKPAVQGPPLPTLAPAQPEKKPVDAETSTEADISTEPSAEVEKEASG 1534
            |         :||.|         |....:.:....|:....:|.|..:|......::|::.:..
Human    64 D---------DSEDE---------GASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGS 110

  Fly  1535 ETSESDNE----IDAGASSTPVPVS----ADEDKTPSTEKTVEADDKFTTVAPLAGDEEE----S 1587
            |....|.:    .|.|:..:....|    :|::|....:|:.::||:...    ..|:||    |
Human   111 EAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQ----NSDDEERAQGS 171

  Fly  1588 NLPKLPQDIFEEEAPVAVTTAAPSKDDGEQKPVEVEEKPIEDGQKPI-EDETSTPTSSENEIEPE 1651
            :..||.....:|:.........|...|.|::.:..|||...|.::|: .|......:|::|.:|:
Human   172 DEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQ 236

  Fly  1652 SDRATTIAPSKEEPSEPSTGAPTKDEPAEPSTDAPESDESKETPE-SEVPTTVAPAGEKIPTSSI 1715
            ......:..|.:|..:.|      ||....|.|..|.|...|:.. |:....|.....|...:|
Human   237 LSDEEKMQNSDDERPQAS------DEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS- 294

  Fly  1716 TPDEEPTATSAPVAKPDEDVEKETSTEIPTDAPASSE-----EDENSSTDQIPSEVPEKKPETPA 1775
                              |.|.::.||:|.|...:.:     :|.:|.:|      .|.||.||.
Human   295 ------------------DSEADSDTEVPKDNSGTMDLFGGADDISSGSD------GEDKPPTPG 335

  Fly  1776 QTPEEGDIVGATAAPTTSDEVPPVQRLPEEVLAEIPQPSTETGIKQQDETTAAPSIDRKEPYVTE 1840
            |..:|..:      |....|..|:.....||  |||:.:|:.|               .:.|..:
Human   336 QPVDENGL------PQDQQEEEPIPETRIEV--EIPKVNTDLG---------------NDLYFVK 377

  Fly  1841 IDEEATTVAPISEKDEKPTEEEKPVEQKPTGEEPSEEE-EKEKPIEQDVSTEGPVSTEASEAGST 1904
            :....:                  ||.:|...:..|:| |.|:.::::..|...:..|.:.....
Human   378 LPNFLS------------------VEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRI 424

  Fly  1905 ESSEEVKPSTEGEVAEKPEDKQPSSTAQAPVETIPEISTELPAQDGDKPTSEAPVDSDEDTSAPS 1969
            ...||     ..|:.|        |.|:....:...:|..|..:..|  ..:||:..|.:
Human   425 RRDEE-----GNEIKE--------SNARIVKWSDGSMSLHLGNEVFD--VYKAPLQGDHN----- 469

  Fly  1970 DEKIPSVSGEEVEGPEVTTASPQAAEEDELKTPAESEPSSTDKVPETEYQKPEDETKADETPESV 2034
              .:....|..::|..|            .||.....|.|||..                |...:
Human   470 --HLFIRQGTGLQGQAV------------FKTKLTFRPHSTDSA----------------THRKM 504

  Fly  2035 T-QVSDVATSTS----APVAGGDIEKDEQATTASPEEEEEIKPTIAPAAEIPQPSEKEPVDEQEV 2094
            | .::|..:.|.    .|:||.|.|.  |.|....:|||.::      |.|.:.|::..:.|::.
Human   505 TLSLADRCSKTQKIRILPMAGRDPEC--QRTEMIKKEEERLR------ASIRRESQQRRMREKQH 561

  Fly  2095 ESGTKATPAESDGQPIDEIAPATSGPIDEASTAAPTK--------EESTTVASAASPAVHDDEIK 2151
            :.|..|:..|.|....:|..       :|:.:.|..|        ||...:.|:.|     ||..
Human   562 QRGLSASYLEPDRYDEEEEG-------EESISLAAIKNRYKGGIREERARIYSSDS-----DEGS 614

  Fly  2152 DVTTTQPVADEKEVAAPQDETKTSIDVSTDSPTAQDDEKQDKTEAPVAPTTVSSPT 2207
            :....|.:...|::.:.::..|      .:.|..::..:|.|.|       ||.||
Human   615 EEDKAQRLLKAKKLTSDEESGK------RERPKLKETWRQWKGE-------VSRPT 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564
		PHA02664	<433..595	CDD:177447
		Ehrlichia_rpt	529..1065	CDD:118064
		DUF863	<1684..>1788	CDD:283539	24/109 (22%)
		VWC	2762..>2805	CDD:302663
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..357		85/416 (20%)
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..583		8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900