Protein Alignment AFF1 and GCR1

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: NP_015250.1
• Gene: GCR1 / 856030
• SGDID: S000005996
• Length: 785
• Species: Saccharomyces cerevisiae
• Alignment Length: 664
• Identity: 133/664 - (20%)
• Similarity: 227/664 - (34%)
• Gaps: 176/664 - (26%)

Human   284 PSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKT----DLKVPAKAKLTK 344
            |.|.|..:::...|..|:     |:|.|:.:..:|.    .|.||||.:    ||..|   .|:.
Yeast   105 PLLDSNFISLNSNPLLYI-----QNQNPNSNSSVKV----SRSQTFEPSKELIDLVFP---WLSY 157

Human   345 LKMPSQSVEQTYSNEVHCVEEILKEM----------THSWPPPLTAIHT------PSTAEPSKF- 392
            ||.....:::| :.:::.:.|:.:.|          ....|..|..|.|      |...:..:|
Yeast   158 LKQDMLLIDRT-NYKLYSLCELFEFMGRVAIQDLRYLSQHPLLLPNIVTFISKFIPELFQNEEFK 221

Human   393 ---PFPTKDSQHVSSVTQNQKQY------DTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTP 448
               .....::..:::||..:.|:      :.|.|..|...:.:..:..::::||      .|.|.
Yeast   222 GIGSIKNSNNNALNNVTGIETQFLNPSTEEVSQKVDSYFMELSKKLTTENIRLS------QEITQ 280

Human   449 EKPPSSSAPPSAPQSL---PEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAP 510
            .|...:|......|.|   .:.::...:..::||:...|........:.:|.:|.
Yeast   281 LKADMNSVGNVCNQILLLQRQLLSGNQAIGSKSENIVSSTGGGILILDKNSINSN---------- 335

Human   511 EPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDP----PP 571
                      .|.|.:..:....:.|.|...|.  :|.|  ||.|.:.....:|.:..|    |.
Yeast   336 ----------VLSNLVQSIDPNHSKPNGQAQTH--QRGP--KGQSHAQVQSTNSPALAPINMFPS 386

Human   572 KSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGL 636
            .|:|..|.....||.|           |:..|::    |.|.....|||..||..|   ....|.
Yeast   387 LSNSIQPMLGTLAPQP-----------QDIVQKR----KLPLPGSIASAATGSPFS---PSPVGE 433

Human   637 LPYGSR---------DQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSG 692
            .||..|         .||:.|....|:...||...|.....||..|.
Yeast   434 SPYSKRFKLDDKPTPSQTALDSLLTKSISSPRLPLSTLANTAVTESF------------------ 480

Human   693 PEPAKDNVEDRTPEHFALVPLTESQGPPH---SGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTK 754
                      |:|:.|        |..|.   .||.|.|:        :.:|:|.....|...:|
Yeast   481 ----------RSPQQF--------QHSPDFVVGGSSSSTT--------ENNSKKVNEDSPSSSSK 519

Human   755 LLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKK----HSSEKRSSDSSS 815
            |....|   .|.:       |..:.:|:.|.:.:......:|.|.:.|.    :|.|.:..:.:.
Yeast   520 LAERPR---LPNN-------DSTTSMPESPTEVAGDDVDREKPPESSKSEPNDNSPESKDPEKNG 574

Human   816 KLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSS 880
            |.:.....:|::......|.       .|:.:::|....:||.||.|.| |||.|::......:.
Yeast   575 KNSNPLGTDADKPVPISNIH-------NSTEAANSSGTVTKTAPSFPQS-SSKFEIINKKDTKAG 631

Human   881 SQKPAKPALKRSRR 894
            ..:..|..|.|..:
Yeast   632 PNEAIKYKLSRENK 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	50/275 (18%)
		PHA03247	<533..800	CDD:223021	62/282 (22%)
		AF-4_C	957..1218	CDD:465894
GCR1	NP_015250.1	PHA03307	362..>616	CDD:223039	71/334 (21%)
		GCR1_C	638..730	CDD:432628	2/8 (25%)