DRSC/TRiP Functional Genomics Resources

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Protein Alignment AFF1 and EUC1

DIOPT Version :10

Sequence 1:NP_001160165.1 Gene:AFF1 / 4299 HGNCID:7135 Length:1218 Species:Homo sapiens
Sequence 2:NP_013829.1 Gene:EUC1 / 855138 SGDID:S000004717 Length:462 Species:Saccharomyces cerevisiae


Alignment Length:507 Identity:87/507 - (17%)
Similarity:160/507 - (31%) Gaps:179/507 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   271 VAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLK 335
            :.|...|:....||.:.:.:.|...:||..:.|           ..:|..||         |:..
Yeast    61 INPLFRPTDAAQPPIVSTSTSASATEPTNRIGP-----------GRIKETPE---------TNFN 105

Human   336 VPAKAKLTKLKMPSQSVEQ----------------------------TYSNEVHCVEEILKEMT- 371
            ....|:||:::..:.::::                            .|..:|..::|:.||:. 
Yeast   106 AFLIAQLTRMEEQNANLKEEISLMKKEQELFFLENQKKLEKGFKDINKYVEDVSAMKEVFKEVVG 170

Human   372 -----------HS----WPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSN 421
                       |:    .|.....:..|||:        |:..|..|..| |.::|    ..|::
Yeast   171 IMTGERIRFIDHTGENVTPQEAARVGNPSTS--------TQAHQSQSRST-NWQEY----SMHAS 222

Human   422 SQQGTSSMLEDDLQLSDSEDS--DSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 484
            ...| ...::.:..|||.|:.  |..::.|...:.:.|.:.|.|    |::|..|:.:.:.|.:.
Yeast   223 ILAG-DPRIKPEPGLSDFENGEYDGNESDENATTRNLPLNNPDS----VSNADDSNNQLDGTGNE 282

Human   485 DSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAP-----PEGPRSTEP 544
            :...:......:|                      ::|:..:..|:..|..     |..|.....
Yeast   283 NDIRNRRGCVGTS----------------------YKLNRAIQNVTDAAREYFEGLPGQPSVLSL 325

Human   545 PRRHPESKGSSDSATSQEHS-------------ESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSP 596
            .||:    ||:...:::|.:             :.||.|.|.....|                  
Yeast   326 ERRY----GSTWRRSAKERTLFTKRMTIIKRIIDIKDDPSKYGLSLP------------------ 368

Human   597 AQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGER----EPGLLPYGSR--DQTSKDKPKVKTK 655
                   ...:...|..|.|: :.|.|:.| .:|..    ...|..|.|:  |:.......:|.:
Yeast   369 -------ENKISRNQAIKVVE-NIRLGNNT-FKGHHCRLSMSQLYEYFSKKMDKLEDYSLTLKRR 424

Human   656 GRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEH 707
            |:||.....|.:.|          :.||..|...        .|....||||
Yeast   425 GKPRRIFLLEEREA----------RLSLQQPHSI--------PNSSTGTPEH 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AFF1NP_001160165.1 AF-4 15..527 CDD:461550 48/301 (16%)
PHA03247 <533..800 CDD:223021 38/199 (19%)
AF-4_C 957..1218 CDD:465894
EUC1NP_013829.1 GCR1_C 296..385 CDD:432628 18/118 (15%)
Blue background indicates that the domain is not in the aligned region.

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