Protein Alignment AFF1 and AIM3

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: NP_009666.3
• Gene: AIM3 / 852405
• SGDID: S000000312
• Length: 947
• Species: Saccharomyces cerevisiae
• Alignment Length: 1002
• Identity: 205/1002 - (20%)
• Similarity: 322/1002 - (32%)
• Gaps: 306/1002 - (30%)

Human   155 AKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDHCASVTDSAPERELSPLISLPS----PV 215
            ||:......:|....:..:|      .|.|.:.:..:...|..:...||:.:.:.||..    |.
Yeast    30 AKTGYKASKKHYNNSKARRE------RKSGKKNSSDEEYDSEDEMEYERKPTDIRSLKDPKSFPP 88

Human   216 PPLSP-----IHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSL----- 270
            |||.|     ....||.:|..|.|....|:.....|  ...:.:....:....:.||..|
Yeast    89 PPLKPGQKTYTGQQQQQMPNGQASYAFQGAYQGQPG--AGSTEQSQYAQPQYNQYPQQQLQQGVM 151

Human   271 ---------VAPAQPP--SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDY 324
                     |.|.|||  .:..||....|.:.:.|..|.        |:|..:..|....|....
Yeast   152 PQQQQLQQGVVPQQPPIYGEQVPPYGSNSNATSYQSLPQ--------QNQPQNAIPSQVSLNSAS 208

Human   325 RQQT-FEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAE 388
            :|.| |...:|:..     |:...|:.|  .::.|.:.|.::           |....|..:...
Yeast   209 QQSTGFVSQNLQYG-----TQSSNPAPS--PSFQNGLQCHQQ-----------PQYVSHGSTNLG 255

Human   389 PSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPS 453
            .|:||    ..|.....||..:|...|.......|||                     .|..||.
Yeast   256 QSQFP----SGQQQQPTTQFGQQVLPSPAQPQQQQQG---------------------QPLPPPR 295

Human   454 SSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDS----------------------ESESSS 496
            ......||   .||:::......:.:.......:.::                      ::.||:
Yeast   296 GQVILPAP---GEPLSNGFGQQQQQQQQQQQPLNQNNALLPQMNVEGVSGMAAVQPVYGQAMSST 357

Human   497 SDSEENEPLETPAP-EPEPPTTNKWQLDNWLTKVSQPAAP----PEGPRSTEPPRRHPESKGSSD 556
            ::.:::.|....:| :.:||..            .||..|    |:.|:..:....:| .:.|.|
Yeast   358 TNMQDSNPSYGASPMQGQPPVG------------GQPPVPVRMQPQPPQPMQQGNIYP-IEPSLD 409

Human   557 SATSQEHSE-----SKDPPPKSSSKAPRA-----PPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQ 611
            |..|..|.|     ...|.||.....|..     ||...|..:.:.    ..|||...   |..|
Yeast   410 STGSTPHFEVTPFDPDAPAPKPKIDIPTVDVSSLPPPPTHRDRGAV----VHQEPAPS---GKIQ 467

Human   612 PKKPVKAS---ARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPS 673
            |.....|:   |:....|:...||..|      ..:..:...|....|......:     .:||.
Yeast   468 PNTTSSAASLPAKHSRTTTADNERNSG------NKENDESTSKSSILGHYDVDVN-----IMPPP 521

Human   674 SEKKKHKSSLPAPSKALSGPE------PAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSG-- 730
            ...:....|:|:.....:.||      |.::||              |...||..|:..||..
Yeast   522 KPFRHGLDSVPSEHTTKNAPERAVPILPPRNNV--------------EPPPPPSRGNFERTESVL 572

Human   731 CRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQ-----SLMVKITLDLL------------- 777
            ...|..||||...:.||.|       .|.|.|...|     :..|::..::|
Yeast   573 STNAANVQEDPISNFLPPP-------KPFRHTETKQNQNSKASPVEMKGEVLPGHPSEEDRNVEP 630

Human   778 SRIPQ-PPGKGSRQRKA-------EDKQPPAGK-KHSSEKRSSDSS--------------SKLAK 819
            |.:|| .|...|:.|:|       ::.|||... :.|....|||||              .::||
Yeast   631 SLVPQSKPQSQSQFRRAHMETQPIQNFQPPPKPFRRSQSSNSSDSSYTIDGPEANHGRGRGRIAK 695

Human   820 KRKGE-----AERDCDNKKI-------------------RLEKEIKSQSSSSSSSHKESSKTKPS 860
            ...|:     :|...:|.::                   |.||..:...:|...|.|:::|.:.|
Yeast   696 HHDGDEYNPKSENSTENGRLGDAPNSFIRKRAPTPPAPSRSEKLHEGTITSEVDSSKDANKYEKS 760

Human   861 RP-------SSQSSKKEMLPPPPVSSSSQKPAKPALKRSR------READTCGQDPPKSASSTKS 912
            .|       :.||:||   .||||  ...||...:||.:.      |||  .|||...::.:.:.
Yeast   761 IPPVTSSIQAQQSTKK---APPPV--VKPKPRNFSLKANEYPKELTREA--TGQDEVLNSITNEL 818

Human   913 NH-------------------KDSS-IPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNS 957
            :|                   |||| :|         |....::..:||....|.|.||    .|
Yeast   819 SHIKLRKTNVNLEKLGGSKKVKDSSPVP---------SDLDEKYVSASGSITPPRPPPS----RS 870

Human   958 KPGKPQVKFDKQQADLHMREAKKMKQK 984
            .|.|......|:..:|..:.....|:|
Yeast   871 SPKKVPPVVPKKNDNLKKKPPVVPKKK 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	75/420 (18%)
		PHA03247	<533..800	CDD:223021	69/317 (22%)
		AF-4_C	957..1218	CDD:465894	7/28 (25%)
AIM3	NP_009666.3	AIM3	8..99	CDD:407240	16/74 (22%)