Protein Alignment AFF1 and lilli

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: NP_523464.1
• Gene: lilli / 33496
• FlyBaseID: FBgn0041111
• Length: 1673
• Species: Drosophila melanogaster
• Alignment Length: 1782
• Identity: 352/1782 - (19%)
• Similarity: 540/1782 - (30%)
• Gaps: 725/1782 - (40%)

Human     5 ERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAF---PEKIPLFGEPYKTAKGDELSSRIQN 66
            :::....|:||:.:.|:.....::||.:|..:.::..   ..:..|||||.:..:||   :.|..
  Fly    44 DQLQQYNNNLYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGD---AEITA 105

Human    67 MLGNYEEVKEFLSTKSHTHRLDASENRLGKPK-YPLIPDKGSSIPSSSFHTSVHHQSIHTPASGP 130
            .||.:.|.:|:::  :.|..:..|....|.|: .|.:..:..|:.        |..|..:.|:||
  Fly   106 ALGEFFEAREYIN--NQTVGISRSAPGAGNPRLQPNLAPQAKSLG--------HSPSSASSAAGP 160

Human   131 LSVGNISHNPKMAQP-RTEPMPSLHAKSCG--PPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDH 192
            .:....:..|...|. :.:..|..:.|...  ||.:        |:.|:.....|.
  Fly   161 TAASATTSLPGQQQHYQQQQRPPTYVKQADNKPPYN--------GRGGYPGQPMKN--------- 208

Human   193 CASVTDSAPERELSPLISLPSP---VPPLSPIHSNQQTLPRTQGSSKVHGS--SNNSKGYCPAKS 252
                             .:||.   .||..|        |||..|:....|  :|.|.|..||.:
  Fly   209 -----------------DIPSSSGMAPPRGP--------PRTSSSNSNSSSVTNNASSGGVPAST 248

Human   253 PKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPEL 317
            |....:........:.|.:.|        |.|:|.:.:......|.|..||..||...|.|....
  Fly   249 PLGPPLSTQMPNGREKSFLGP--------PAPALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVN 305

Human   318 K-----------------------PLPEDY------RQQ----------TFEKTDLKVPAKAKLT 343
            |                       |..|:|      ||:          :.|.:.|..|..|.:|
  Fly   306 KIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPIT 370

Human   344 K-----LKMPSQSVEQTYSNEVH---CVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQ 400
            .     :..|.|:.:........   ...|.|..: |..||.:     |..|.....|.|.|..:
  Fly   371 SPIAPLVTTPPQASQMPLGGATSGTILAGEALAPL-HQLPPTM-----PKAASGVTSPGPVKPLK 429

Human   401 HVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED------------------------ 441
                          :.|.||..:|  .|.||:||:||:|||
  Fly   430 --------------TEKNHSLEKQ--DSCLENDLELSESEDEQRKKEGRSGGNSSNSSESDSSES 478

Human   442 ----------------------------------------------------------------- 441
                                                                             
  Fly   479 GSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIA 543

Human   442 ----------------------------------------------SDSEQTP------------ 448
                                                          |.|.:||
  Fly   544 RGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESNKWNLSR 608

Human   449 --EKPPS-----SSAP-----------PSAPQSLPE----------------------------- 466
              .||.:     |.:|           |...|.:||
  Fly   609 FFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEE 673

Human   467 ------------PVA------SAHSSSA-----------ESEST------SDSDSSSDSESESSS 496
                        |||      .|.|..|           ||..|      |||.:|:...|.|||
  Fly   674 QQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSS 738

Human   497 SDSEE---NEPLETPAPE-----PEPPTTNKWQLDNWLTKVS--QPA----APPEG--------P 539
            |.|:.   .|.:..|.|.     |..|..        :|.|.  ||.    |||..        |
  Fly   739 SSSDSAMGGEVVPMPGPGETLQLPGVPAA--------ITTVMRVQPTQSQKAPPSNSVTLTPILP 795

Human   540 RSTEPPRRH--PESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPP 602
            ..|.|.:|.  |..|.:..||...:.|:..:||||             |||..  ..:.:.|..|
  Fly   796 LPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPK-------------HPGLD--HTAVSVQTQP 845

Human   603 QRQTV--GTKQPKKPVK-------ASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKT---- 654
            ...||  |..:|:|..:       :||.|||.:..:|   |.|        |:..||..||
  Fly   846 ATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKG---PTL--------TAAKKPLAKTPLAM 899

Human   655 -KGRPRAAAS------NEP--KPAVP-----------------------PSSEKKKHKSSLPAPS 687
             :.|.|..:|      |.|  |.|.|                       .||.:...|||..:.|
  Fly   900 SRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSS 964

Human   688 ------------------------KAL-----SGPEPAKDNVEDRTPEH--------------FA 709
                                    |||     |.|..:....||:|...              :.
  Fly   965 SDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYK 1029

Human   710 LVPLTE-SQGPPHSGSGSRTSGCR----------------------------------------- 732
            .:|::: ||....|...|.:.||.
  Fly  1030 QLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKE 1094

Human   733 -------QAVVV--QEDSRKDRLPLPLRDTK----------------------------LLSPLR 760
                   |.|:|  ||:.::.:|....:.:.                            |.||.|
  Fly  1095 GGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPAR 1159

Human   761 DTPPP-QSLMVKITLDLLSR---------------------------IPQPPGKGSRQRKAEDKQ 797
            .|.|. .||:.||.|..|||                           :..|.|      .|.|..
  Fly  1160 TTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNG------YAGDTN 1218

Human   798 PPAGKKHSSE--------------------------KRSSDSSSKLAKKRKGEAERDCDNKKIRL 836
            |.|..||...                          |:..|...:..::|:.|.|||.:.::...
  Fly  1219 PAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPG 1283

Human   837 EKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPP---PVSSSSQKPAKPALKRSRRE--- 895
            .:. |..||||||.:||..:.|......|.. ||:||.|   |.::..:.|....|...:.:
  Fly  1284 RRR-KRSSSSSSSPYKEKKRKKEKADQLQMG-KELLPVPVLLPSNNHERMPNHDRLSYDKLQLLH 1346

Human   896 ---ADTCGQDPPKSASSTKSNHKDSSIPKQRRVE------GKGSRSSSEHKGSSGDTANPFPVPS 951
               |...|.....:.|.||.....|.:|....|.      .:..:::.....::...|.|.|...
  Fly  1347 EDAAAVIGDVSAPNGSPTKKLLAMSPLPPPPTVTVAPATCNEAVQTTPPSATATSAIAPPVPATR 1411

Human   952 L------------PNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLS 1004
            |            |:.           |.::.:..::||...|..|:|..|...:...|||||:.
  Fly  1412 LIYRSYFDRDVEHPSD-----------DPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVY 1465

Human  1005 FIECGIATESESQSSKSAYSVYSETVDLIKFIMS------LKSFSDATAPTQEKIFAVLCMRCQS 1063
            |:....|.| ...|.::..::|.:|:.|||||.:      .:|.::....|..|: |:|.:||||
  Fly  1466 FLLTADAME-RCSSEQATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKV-AILSLRCQS 1528

Human  1064 ILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSA 1128
            ::::.:::.::    |..|.:........:|.:..   ||.. .|||.:    ||::|||||.|
  Fly  1529 LISLKLYKLRR----KDCRAIINSLTDFFRVGRGD---IANG-NTPSSI----SPSNSVGSQGS- 1580

Human  1129 GSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNK--EFFARLSTNVCTL 1191
               ||:.....| .|..|.||........|::.:|.:||:||:.|.|...  :|...|......|
  Fly  1581 ---GSNTPPGRI-VPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPL 1641

Human  1192 ALNSSLVDLVHYTRQGFQQLQELTKTP 1218
            .|:|::.::..|.:.|.:.|::....|
  Fly  1642 TLHSTMHEVFRYVQAGLKTLRDAVSHP 1668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	139/807 (17%)
		PHA03247	<533..800	CDD:223021	93/475 (20%)
		AF-4_C	957..1218	CDD:465894	71/268 (26%)
lilli	NP_523464.1	AF-4_C	1435..1662	CDD:465894	69/245 (28%)