Protein Alignment AFF1 and Aff1

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: XP_038947749.1
• Gene: Aff1 / 305152
• RGDID: 1307940
• Length: 1228
• Species: Rattus norvegicus
• Alignment Length: 1243
• Identity: 876/1243 - (70%)
• Similarity: 982/1243 - (79%)
• Gaps: 70/1243 - (5%)

Human    14 LYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFL 78
            |||:|||||||||||||||||||||||||||.|||.||||||||||||||||.|||:|||:||||
  Rat    16 LYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFAEPYKTAKGDELSSRIQTMLGDYEEMKEFL 80

Human    79 STKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMA 143
            |:|||.||||.||:|.|||:||...|:||. .|.||.|.|:||..||.|.|.|||.|:|.:||||
  Rat    81 SSKSHPHRLDGSEDRPGKPRYPSCHDRGSG-ASGSFRTHVYHQPTHTSAPGSLSVSNVSQSPKMA 144

Human   144 QPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH-HKKGDRRADGDHCASVTDSAPERELSP 207
            |||.||:||||||..|.||.....||||.|     .| .:|.||||:||         .||:|||
  Rat   145 QPRMEPVPSLHAKIYGAPDGPRPAQDRLSQ-----GHCSRKCDRRAEGD---------SERKLSP 195

Human   208 LI-SLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLV 271
            .| |||||||||||.||      |.|.:||.|||...::....:|..||..|...:||||.||||
  Rat   196 FISSLPSPVPPLSPAHS------RPQATSKAHGSGTGTQSCYASKPSKDPVVTAQEKETPLDSLV 254

Human   272 -------APAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTF 329
                   ||.|||.||||||.|||||:||||||||||||||||||||||||||||..||:.||:|
  Rat   255 AVTSLGAAPPQPPCQTFPPPPLPSKSIAMQQKPTAYVRPMDGQDQAPSESPELKPPLEDFGQQSF 319

Human   330 EKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPF 394
            ||.|||||||||||:|:||||:|||.||||||||||||||||||||.||||||||||||||:|||
  Rat   320 EKPDLKVPAKAKLTRLRMPSQTVEQPYSNEVHCVEEILKEMTHSWPSPLTAIHTPSTAEPSRFPF 384

Human   395 PTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPS 459
            ||||..|:||.||:|||||..||||.|.|||| |||||||||||||:||.||..|||||..||||
  Rat   385 PTKDPLHISSATQSQKQYDAPSKTHPNPQQGT-SMLEDDLQLSDSEESDVEQAVEKPPSPPAPPS 448

Human   460 APQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDN 524
            |||::|||||||||||||||| |:||||||||||||||||||||||||.||||||||||||||||
  Rat   449 APQTIPEPVASAHSSSAESES-SESDSSSDSESESSSSDSEENEPLETQAPEPEPPTTNKWQLDN 512

Human   525 WLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGK 589
            |||||:||:.|.|...|||.||...||||..:..:.|:|.:|||||.||||||.|.|.|.|.|||
  Rat   513 WLTKVNQPSVPLESRGSTESPRCRQESKGGGEGGSDQQHPDSKDPPLKSSSKALRGPSEGPQPGK 577

Human   590 RSCQKSPAQQE-PPQRQTVGTKQPKKPVKASARAGS-RTSLQGEREPGLLPYGSRDQTSKDKPKV 652
            |:|.||||||| ||.|||||:|||:||.|.|.:|.. :.|.:.|.|.|.:.|||::|||||||||
  Rat   578 RNCPKSPAQQETPPPRQTVGSKQPRKPTKGSTQAEQPQASSRVEGEAGPVAYGSKEQTSKDKPKV 642

Human   653 KTKGRPRAAASNEPK----------------PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVE 701
            ||||||||..|.|||                |..|...||:||||| .|||||||||:|.||:..
  Rat   643 KTKGRPRAVGSREPKSEVPVPVPQAAVPKPQPPAPTPIEKRKHKSS-TAPSKALSGPQPTKDSAG 706

Human   702 DRTPEHFALVPLTESQGPPHSGSGS---RTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTP 763
            ||..||.|||.||:|||.|:||.||   |||||||||:.||||.:|:|.||||||||||||||:|
  Rat   707 DRNQEHPALVSLTQSQGQPNSGRGSGGGRTSGCRQAVITQEDSCRDKLLLPLRDTKLLSPLRDSP 771

Human   764 PPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERD 828
            ||.||:||||||||:|:|||||||.|.||:|.||.|||||...|.|..||||::.||||.|.|::
  Rat   772 PPTSLVVKITLDLLTRVPQPPGKGGRPRKSEHKQLPAGKKQDLEARGCDSSSRVTKKRKAEPEKE 836

Human   829 CDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPV-------SSSSQKPAK 886
            ..:|::||:   |||:|||||||.||||:|..||||:.|:|||||||||       |||||||:|
  Rat   837 HSHKRLRLD---KSQTSSSSSSHAESSKSKTPRPSSECSRKEMLPPPPVVPSSSSSSSSSQKPSK 898

Human   887 PALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPS 951
            ||.||.|.:||...||||:|:.||||:..|||:||.|:|:.:    .|||||||||.||||||||
  Rat   899 PAHKRPRPDADIGSQDPPRSSGSTKSSCTDSSVPKHRKVQAR----DSEHKGSSGDAANPFPVPS 959

Human   952 LPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESES 1016
            ||||||||||||||.|:||||.||:||||:|.|||.|.|:.|||||||||||||||||:||||||
  Rat   960 LPNGNSKPGKPQVKSDRQQADFHMKEAKKLKCKAEAMVDKAGKAFKYLEAVLSFIECGMATESES 1024

Human  1017 QSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYS 1081
             |:||||:|||||||||||:||||||||.|.|.|||||||||:||||:|||||||||||..:|||
  Rat  1025 -SAKSAYTVYSETVDLIKFVMSLKSFSDNTVPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYS 1088

Human  1082 RTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAG-SVGSSGVAATISTPVT 1145
            |||::||.|:||||||||||:|||||.|||:|||||||||.|||:||| |:|:.|..||:|||||
  Rat  1089 RTLSEHFRSTSKVAQAPSPCVARSTGVPSPVSPMPSPASSAGSQTSAGSSMGAMGATATVSTPVT 1153

Human  1146 IQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQ 1210
            ||||||||||||||||.||.|||||||||||||||||:|||.|..|||||||||||||||||.|:
  Rat  1154 IQNMTSSYVTITSHVLKAFTLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVHYTRQGLQR 1218

Human  1211 LQELTKTP 1218
            |::..:||
  Rat  1219 LRQAPQTP 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	379/520 (73%)
		PHA03247	<533..800	CDD:223021	177/287 (62%)
		AF-4_C	957..1218	CDD:465894	209/261 (80%)
Aff1	XP_038947749.1	AF-4	17..515	CDD:461550	379/520 (73%)
		AF4_int	776..790	CDD:436798	10/13 (77%)
		AF-4_C	965..1226	CDD:465894	209/261 (80%)