Protein Alignment AFF1 and Aff1

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: NP_001074267.1
• Gene: Aff1 / 17355
• MGIID: 1100819
• Length: 1226
• Species: Mus musculus
• Alignment Length: 1251
• Identity: 889/1251 - (71%)
• Similarity: 991/1251 - (79%)
• Gaps: 75/1251 - (5%)

Human     9 SSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEE 73
            |.|..|||:|||||||||||||||||||||||||||.|||.||||||||||||||||.|||:|||
Mouse    10 SGGACLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYKTAKGDELSSRIQTMLGDYEE 74

Human    74 VKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISH 138
            :|||||:|||.||||.||:|.|||:|||..|:|:...|||..|.|:||.|||.|.|...||||||
Mouse    75 MKEFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAASSSLRTHVYHQPIHTSAPGSRPVGNISH 139

Human   139 NPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH-HKKGDRRADGDHCASVTDSAPE 202
            :|||||||.|  ||||.|..   |...||||.|.|     .| .:|.||||:|       |||||
Mouse   140 SPKMAQPRME--PSLHTKIY---DGPRLTQDHLSQ-----GHCSRKCDRRAEG-------DSAPE 187

Human   203 RELSPLI-SLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETP 266
            |:||||| |||||||||||:||      |.||:||.|.|..:||..|.|||.|||..|..|||||
Mouse   188 RKLSPLISSLPSPVPPLSPVHS------RLQGTSKAHSSGVSSKSCCVAKSSKDLVAKAQDKETP 246

Human   267 QDSLV-------APAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDY 324
            .|.||       ||.|||.||||||.|||||.|||||||||||||||||||||||||||...|||
Mouse   247 HDGLVAVTSLGSAPPQPPCQTFPPPPLPSKSAAMQQKPTAYVRPMDGQDQAPSESPELKLPLEDY 311

Human   325 RQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEP 389
            .||:|||.|||||||||||:|:||||||||.||||||||||||||||||||||||||||||||||
Mouse   312 GQQSFEKPDLKVPAKAKLTRLRMPSQSVEQPYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEP 376

Human   390 SKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSS 454
            |:|||||||..|||..||:||||||.||||.|.|||| ||||||||||||||||:||..|||||.
Mouse   377 SRFPFPTKDPLHVSPATQSQKQYDTPSKTHPNPQQGT-SMLEDDLQLSDSEDSDTEQATEKPPSP 440

Human   455 SAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDS---EENEPLETPAPEPEPPT 516
            .|||||||:||||||||||||.|||| |:||||||||||||||||   ||||||||.||||||||
Mouse   441 PAPPSAPQTLPEPVASAHSSSGESES-SESDSSSDSESESSSSDSEEEEENEPLETRAPEPEPPT 504

Human   517 TNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAP 581
            |||||||||||||:||:.|.:|..|||.|:...||||.::.::.|:|.:||||.||||||..|.|
Mouse   505 TNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSDQQHPDSKDPLPKSSSKTLRGP 569

Human   582 PEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTS 646
            .|.|.||||.|.|||||||||.|||||:|||:||.|.|.:|..:.|.|.|.|.|.|||||::|||
Mouse   570 SEGPQPGKRGCPKSPAQQEPPPRQTVGSKQPRKPAKGSGQAEPQASSQAESEVGPLPYGSKEQTS 634

Human   647 KDKPKVKTKGRPRAAASNEPKPAVP---------------PS-SEKKKHKSSLPAPSKALSGPEP 695
            ||:|||||||||||..|.||||.||               |: |||:||||| .|||||.|.|:|
Mouse   635 KDRPKVKTKGRPRAVGSREPKPEVPAPTPQAAVPRPKPPVPTPSEKRKHKSS-TAPSKAPSAPQP 698

Human   696 AKDNVEDRTPEHFALVPLTESQGPPHSGSGS----RTSGCRQAVVVQEDSRKDRLPLPLRDTKLL 756
            .||:..||.|||.|||.||:||||.||..||    |||||||||:.|.|..||:|.|||||||||
Mouse   699 PKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRTSGCRQAVIAQGDGCKDKLLLPLRDTKLL 763

Human   757 SPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKR 821
            |||||:|||.||:||||||||:|||||.|||||.|||||||..||||..||.:|.||||::.|||
Mouse   764 SPLRDSPPPTSLVVKITLDLLTRIPQPLGKGSRPRKAEDKQLSAGKKQDSETKSCDSSSRVTKKR 828

Human   822 KGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPV-----SSSS 881
            ||:.|::..||:.:|:   |||::||||||.|||:||..|.||::|:||||||...     ||||
Mouse   829 KGDPEKEHSNKRHKLD---KSQTASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSS 890

Human   882 QKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGD---T 943
            |||::||.||.|.:.|||.|:||:|||||||:..|...||.|:|:.:|    |||||||||   .
Mouse   891 QKPSRPAQKRPRPDEDTCSQEPPRSASSTKSSSTDPPAPKHRKVQARG----SEHKGSSGDAANA 951

Human   944 ANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIEC 1008
            |||||||||||||:||||||||.|:||||.||:||||:|.|||.|.|:.||||||||||||||||
Mouse   952 ANPFPVPSLPNGNAKPGKPQVKSDRQQADFHMKEAKKLKCKAETMVDKAGKAFKYLEAVLSFIEC 1016

Human  1009 GIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCK 1073
            |:|:|||| |:||||:|||||:|||:::||||.|||.|.|.|||||||||:||||:|||||||||
Mouse  1017 GMASESES-SAKSAYAVYSETIDLIRYVMSLKCFSDNTMPAQEKIFAVLCLRCQSLLNMAMFRCK 1080

Human  1074 KDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAG-SVGSSGVA 1137
            ||..:||||||::||:|:||||||||||.|||||.||||||||||||||||||||| |:||.||.
Mouse  1081 KDTVMKYSRTLSEHFKSTSKVAQAPSPCTARSTGVPSPLSPMPSPASSVGSQSSAGSSMGSVGVT 1145

Human  1138 ATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVH 1202
            ||:||||:|||||||||||||||||||.|||||||||||||||||:|||.|..||||||||||||
Mouse  1146 ATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVH 1210

Human  1203 YTRQGFQQLQELTKTP 1218
            |||||.|:|::..|.|
Mouse  1211 YTRQGLQRLKQSPKGP 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	392/523 (75%)
		PHA03247	<533..800	CDD:223021	181/286 (63%)
		AF-4_C	957..1218	CDD:465894	209/261 (80%)
Aff1	NP_001074267.1	AF-4	16..515	CDD:461550	392/523 (75%)
		PHA03247	<362..699	CDD:223021	239/339 (71%)
		AF4_int	775..789	CDD:436798	11/13 (85%)
		AF-4_C	965..1226	CDD:465894	209/261 (80%)