Protein Alignment AFF1 and aff1

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: XP_073791690.1
• Gene: aff1 / 100537394
• ZFINID: ZDB-GENE-110228-2
• Length: 720
• Species: Danio rerio
• Alignment Length: 1233
• Identity: 280/1233 - (22%)
• Similarity: 413/1233 - (33%)
• Gaps: 556/1233 - (45%)

Human     9 SSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEK------IPLFGEPYKTAKGDELSSRIQNM 67
            :..:|:..::||:||..|:|||:|||.||:|   |:      .|||.:|:|...||.||||||:|
Zfish     2 TGASSVQMEERNMLRRMERERRSQEAQQEEE---EQYRTHTHTPLFSQPFKRVCGDALSSRIQSM 63

Human    68 LGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLS 132
            ||:||                              |:
Zfish    64 LGDYE------------------------------PE---------------------------- 70

Human   133 VGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDHCASVT 197
                   |:...||.         .|||.:
Zfish    71 -------PQCVSPRA---------LCGPAE----------------------------------- 84

Human   198 DSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHD 262
                               ||||:
Zfish    85 -------------------PLSPL----------------------------------------- 89

Human   263 KETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQ 327
             :||:.| .:|.:|     .||..||:...: |||||||||:|||:...: |||  ||
Zfish    90 -QTPEHS-PSPRRP-----TPPRAPSRPAPL-QKPTAYVRPLDGQEPLRA-SPE--PL------- 136

Human   328 TFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKF 392
                .|||....|.      |.|.: ...|.:..||.:||:||| ||||.||:||||.|.||
Zfish   137 ----QDLKESGTAG------PLQPI-GVCSAQCVCVLDILQEMT-SWPPLLTSIHTPDTEEP--- 186

Human   393 PFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGT---SSMLEDDLQLSDSEDSDSEQTPEKPPSS 454
                            ||...|:.:||.::...|   |..:|.:||
Zfish   187 ----------------QKSQSTAEETHGHTALKTLESSGRVELELQ------------------- 216

Human   455 SAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPE-PEPPTTN 518
                                 ..|..:|||||||||::|.|||      |:...:|| ......|
Zfish   217 ---------------------EASSCSSDSDSSSDSDNEKSSS------PVRPLSPEDTHTQKGN 254

Human   519 KWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPE 583
            .|.:..|..                 .|.|..|.||                       ||
Zfish   255 DWPMGRWYR-----------------AREHQLSPGS-----------------------PR---- 275

Human   584 APHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKD 648
                ....|..:|||                |..:|.....|.::..|
Zfish   276 ----DVIVCHDAPAQ----------------PADSSTHTDRRRTVVCE----------------- 303

Human   649 KPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPL 713
              .:.|:....|.||..        :.|.:.|.|..|..:..:
Zfish   304 --TLLTESTHTADASTH--------THKHRRKESCQAEQRKST---------------------- 336

Human   714 TESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLS 778
            |...|..|:|..:                                     |.:.|:|||.|:|||
Zfish   337 TGGHGGKHTGGKA-------------------------------------PRRPLLVKIQLNLLS 364

Human   779 RIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQ 843
            |:|:.|.               |..|    |:..:|   |:||..||......||.:|:||.|..
Zfish   365 RVPREPD---------------GDPH----RTCGAS---ARKRTAEAIEKPSKKKQKLDKEGKLS 407

Human   844 SSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSAS 908
            ||...|........|.||.||     .:.|.|.|:|:          |.:..|:...:.|.||..
Zfish   408 SSVQHSQSDTGQMKKRSRHSS-----GLGPRPAVASA----------RPQEGAEAHWKKPGKSCR 457

Human   909 STKSNHKDSSI---PKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQ 970
            ..:......::   .:||.||.
Zfish   458 ELEQTENTGALLPEHRQRSVED------------------------------------------- 479

Human   971 ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQS-SKSAYSVYSETVDLIK 1034
               |::||||:|.:|:...::..||..||||.|:|::.|:|.:.|..: ::|:|::.|||::||:
Zfish   480 ---HLKEAKKLKHRADATVEKSAKALLYLEAALAFVQSGVAMQEEPHTHTRSSYTMLSETLELIR 541

Human  1035 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFE-------SSS 1092
            ||:.||:::|:::   |:.|.:||:|||::|.|.|||.::.:|::|||||.:||:       ...
Zfish   542 FILKLKNYADSSS---ERDFFILCLRCQALLQMTMFRYRQQVALRYSRTLTEHFQGWCCLPCGRG 603

Human  1093 KVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAG-----SVGSSG-------------VAAT 1139
            :|.:..|...|...|.....|..|..:..:|:..:||     |...||             ..|.
Zfish   604 RVTRHSSAGAADGAGVRQHHSARPERSRHLGAGGAAGTQRQRSAAGSGCVRRASESELPHQCTAA 668

Human  1140 ISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRK---NKEFFARLSTNVCTLALNSSLVD 1199
            :.||     ..::..|..:|.|.:..::..|...|.:   ..|...|     |.| |:.|::|
Zfish   669 VHTP-----RPAAPQTAHTHTLKSSSVYAHAHTHTHRVAVGAEVLFR-----CVL-LSCSVID 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	127/521 (24%)
		PHA03247	<533..800	CDD:223021	39/266 (15%)
		AF-4_C	957..1218	CDD:465894	77/272 (28%)
aff1	XP_073791690.1	None