Protein Alignment AFF1 and aff1

DIOPT Version :10

• Sequence 1: NP_001160165.1
• Gene: AFF1 / 4299
• HGNCID: 7135
• Length: 1218
• Species: Homo sapiens
• Sequence 2: XP_002941543.3
• Gene: aff1 / 100497189
• XenbaseID: XB-GENE-5995345
• Length: 1160
• Species: Xenopus tropicalis
• Alignment Length: 1236
• Identity: 572/1236 - (46%)
• Similarity: 745/1236 - (60%)
• Gaps: 118/1236 - (9%)

Human     9 SSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEE 73
            |:.:||||::||||||||:||||||||||:|.|....|||.|||||:||||||||||:|||||||
 Frog     5 SAQSSLYNEERNLLRIRERERRNQEAHQERETFSNCAPLFPEPYKTSKGDELSSRIQSMLGNYEE 69

Human    74 VKEFLSTKSHTHRLDASE-----NRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTP---ASGP 130
            ::|.:..|::|...|:|:     :.|.||:...:   |.||||:.. :|.|||...|.   :|..
 Frog    70 IEELIVAKTNTQIFDSSKSAVLVSSLRKPERQRV---GPSIPSTDV-SSGHHQRPQTDNDISSWQ 130

Human   131 LSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDHCAS 195
            |:.   ||||..:          |::...|.:.|..|:..           .|..:|.:...||.
 Frog   131 LTK---SHNPVRS----------HSQDLIPCEQQSRTKPM-----------DKNGKRLEECGCAE 171

Human   196 VTDSAPE-RELSPLI-SLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAV 258
            .:.|... ..||||: ||.|||.||||:||.|:|..:.: :.:.|..:|..            |.
 Frog   172 QSPSPSSISALSPLLSSLSSPVEPLSPLHSTQKTDSKLR-TGQAHDKTNRH------------AS 223

Human   259 KVHDKETPQD--SLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLP 321
            .|.:....:|  :.|......:||| ||||.||:.||.|||||||||||||||.|||||.:|||.
 Frog   224 PVQNDTGNRDGSASVTNLMTATQTF-PPSLSSKTSAMPQKPTAYVRPMDGQDQVPSESPYIKPLQ 287

Human   322 EDYRQQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPS 385
            |||.::::|. ||      .||:||:.|.:|.: |.|||..||||||||||||||||||||||||
 Frog   288 EDYHEESYESLTD------EKLSKLENPPESFD-TLSNEAQCVEEILKEMTHSWPPPLTAIHTPS 345

Human   386 TAEP---SKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT 447
            |:||   |||.||:|.:|.|.||..||||||||||.....||.| |||||||:||||::||..:.
 Frog   346 TSEPSKFSKFSFPSKGNQRVPSVKGNQKQYDTSSKQLPCPQQRT-SMLEDDLELSDSDNSDDNEI 409

Human   448 PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEP 512
            .:|..|||.|||..||....|.||||||.|||| |:|||||||||..:||:||..||...|.|||
 Frog   410 CDKQASSSVPPSVLQSQNNSVVSAHSSSLESES-SESDSSSDSESGDNSSESEVIEPPSVPTPEP 473

Human   513 EPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPR-RHPESKGSSDSATSQEHSESKDPPPKSSSK 576
            :|   :.|||.:::.||.|..||.|.....:..: .|.|||  |..:.|....||......|..|
 Frog   474 DP---DIWQLRHYMNKVGQSTAPVENHSIVDHEQSNHWESK--SQGSISPTPHESPKNLESSHKK 533

Human   577 APRAPPEAPHPGKRSCQKSPA-QQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYG 640
            :|....|... .|..|..||. .:....|||.|.|||.|.:|..........|:.|.|    ||.
 Frog   534 SPWTSLEEVQ-NKEDCPDSPVISKTVTPRQTAGIKQPSKSLKLLGPEEPNVGLKVESE----PYR 593

Human   641 SRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPS-KALSGPEPAKDNVEDRT 704
            .|||.||:||.||||.:.:  .:.:||.::..:.||||||||....| |..|.....|.:.....
 Frog   594 PRDQPSKEKPSVKTKDKNK--LNKDPKTSIAQTIEKKKHKSSHHGSSNKKCSNSLLEKSHSTHSL 656

Human   705 PEHFALVPLTESQGPP------HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTP 763
            |::           ||      .|.:...|.....||||:|:..:|::.||:.:.: |.||.:..
 Frog   657 PQY-----------PPSVQVKNQSKANHMTHLSHPAVVVRENLHRDKVLLPIGENR-LPPLSNNH 709

Human   764 PPQSLMVKITLDLLSRIPQPPGKGS--RQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRK-GEA 825
            ....|:|||.|.||||:|...||.:  :.:|..:|:..:.:|..||::.|.:.||...||| .|.
 Frog   710 KSCPLVVKIELSLLSRVPGVAGKANQHKNKKENNKEISSLRKEESERKHSQNHSKEHTKRKVEEG 774

Human   826 ERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALK 890
            ||:..:|||:||.||||.     ||.|:....|..:.||:|..|:.....|...:..||.|...|
 Frog   775 ERNGTHKKIKLETEIKSH-----SSQKQLPTKKVPKESSESFPKKHWQEKPSEHTQTKPEKLPQK 834

Human   891 RSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNG 955
            |...|......    .::::||:||:.|..|||:||...|.....:|||:.:....|||||||||
 Frog   835 RHPSENTIYSH----LSATSKSSHKEPSSSKQRKVEENLSYHVKINKGSAENNTKAFPVPSLPNG 895

Human   956 NSKPGKPQVKFDKQ--QADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQS 1018
            |.||.:||:||:::  ..:.:|:||||:|.||:.|:|::||:|.||:|.:.|||||||.|::.|:
 Frog   896 NVKPTRPQLKFEEKLMSPEHYMKEAKKLKHKADAMSDKIGKSFNYLDAAMFFIECGIAMEADVQA 960

Human  1019 SKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRT 1083
            .||||::.:|||||||||:.||:|:|.:||:.|..||||||||||||.|||||.|||.|||||||
 Frog   961 PKSAYTMIAETVDLIKFILKLKNFTDFSAPSYEMSFAVLCMRCQSILYMAMFRYKKDTAIKYSRT 1025

Human  1084 LNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGS-SGV-AATISTPVTI 1146
            |.:||:|||:.|||||||:.|||||||||||.||||||.|||  .||:.| ||. :::::.|..|
 Frog  1026 LGEHFKSSSRAAQAPSPCVTRSTGTPSPLSPTPSPASSGGSQ--PGSIASNSGTPSSSVAIPQMI 1088

Human  1147 QNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQL 1211
            .::.||||.|||:.|.|:|:||||:.|.:|:|||||.||..||.|||||.:..||||||||.|.|
 Frog  1089 HHIASSYVNITSYFLYAYDIWEQADLLAKKHKEFFADLSEVVCPLALNSPMDKLVHYTRQGLQWL 1153

Human  1212 Q 1212
            :
 Frog  1154 R 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFF1	NP_001160165.1	AF-4	15..527	CDD:461550	260/527 (49%)
		PHA03247	<533..800	CDD:223021	88/277 (32%)
		AF-4_C	957..1218	CDD:465894	158/260 (61%)
aff1	XP_002941543.3	AF-4	11..485	CDD:461550	260/527 (49%)
		AF4_int	714..728	CDD:436798	9/13 (69%)
		AF-4_C	898..1159	CDD:465894	158/259 (61%)