DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mah and AVT3

DIOPT Version :9

Sequence 1:	NP_651316.1	Gene:	mah / 42988	FlyBaseID:	FBgn0285912	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_012776.1	Gene:	AVT3 / 853710	SGDID:	S000001629	Length:	692	Species:	Saccharomyces cerevisiae

Alignment Length:	553	Identity:	119/553 - (21%)
Similarity:	193/553 - (34%)	Gaps:	191/553 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NAKP------APRPS-----RAP-----SFALPKRRPPVQLTPSHQHD-QLP-FLRRSRFSALP- 53
            |..|      ||.|.     |||     ||.:.|||       .|..| .:| |..|:....|.
Yeast   193 NGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRR-------KHNVDAPIPNFFTRNFIEFLTL 250

  Fly    54 --HF------------RAYEDEPENLSL---------------------FIAILYVVDLFGIFPF 83
              ||            ...|:|||..:|                     ..|:|.::..|.....
Yeast   251 YGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVGTGV 315

  Fly    84 VTLPALLVKLGY-FGILLVLSIIILQIYTSFLLSQCWTMAEL-LDPSIQQKRNYPYAALAELAYG 146
            :.||......|: |..|.:||..::. |..| :|...|..:: :|         .|..:..:.||
Yeast   316 LFLPKAFHNGGWGFSALCLLSCALIS-YGCF-VSLITTKDKVGVD---------GYGDMGRILYG 369

  Fly   147 PYMSLLVSVLLDLSIFAMAVPSVVMAAQNLEGV---VLRMSAGQYNFSYCYWAIIVGLVICPLMW 208
            |.|...:...:.||....:....|..|.||:..   ...:..|..:.:...:|.:  |:..||..
Yeast   370 PKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQV--LIFVPLSL 432

  Fly   209 LGSPKHMRGLAIIAVCVMIVIVALLW--------------------------FCLFAAPAIGTPF 247
            ..:...:.|.|:||  .:.:::.|::                          :.||...||.| |
Yeast   433 TRNIAKLSGTALIA--DLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNKADWSLFIGTAIFT-F 494

  Fly   248 EGISLELPGFLTVLNSYSILAFQFDIHPVLLTLQIDMKQ----KSQVSWAALIGIAITCSVA-IF 307
            |||.|.:|                        :|..||.    :..:|       |:.|.|| ||
Yeast   495 EGIGLLIP------------------------IQESMKHPKHFRPSLS-------AVMCIVAVIF 528

  Fly   308 GS--IIAAYKFGSMIADNLLQSLPTSVPF-------YVMLILMA--LQLCFSVTVASSAMFMQ-- 359
            .|  ::....|||.:...:|.:.|....:       |.:.||::  |||..::.:..:..|..
Yeast   529 ISCGLLCYAAFGSDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNA 593

  Fly   360 ----------IENYFKLPESLSFKRMLIRSSVLALEVLVAEFVPS--FDALMDVVGGTITGPLVF 412
                      ::|||:.       .:::.:|:||       :|.:  .|..:.:||.....||::
Yeast   594 SGKYNPKVKWLKNYFRC-------AIVVLTSILA-------WVGANDLDKFVSLVGSFACIPLIY 644

  Fly   413 ILPPLLYRRIRRMERVHQRIAAEASYGSLPLDL 445
            |.||||:.:        ..|.:..|...|.|||
Yeast   645 IYPPLLHYK--------ASILSGTSRARLLLDL 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mah	NP_651316.1	SLC5-6-like_sbd	110..426	CDD:294310	77/375 (21%)
AVT3	NP_012776.1	Aa_trans	295..687	CDD:279788	93/444 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810