DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mah and Slc38a9

DIOPT Version :9

Sequence 1:	NP_651316.1	Gene:	mah / 42988	FlyBaseID:	FBgn0285912	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001030328.1	Gene:	Slc38a9 / 310091	RGDID:	1311881	Length:	559	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	101/488 - (20%)
Similarity:	177/488 - (36%)	Gaps:	118/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PAPRPSRAPSFALPKRRPPVQLTPSHQHDQLPFLRRSRFSALPHFRAYEDEPENLSLFIAILYVV 75
            ||.:...||...:|        .|...:...|.  .|.:....:...|.   :|.||....:...
  Rat    76 PADKALIAPDHVVP--------APEECYVYSPL--GSAYKLKSYTEGYR---KNTSLVTIFMIWN 127

  Fly    76 DLFGIFPFVTLPALLVKLGY-FGILLVLSIIILQIYTSFLLSQCWTMAELLDPSIQQKRNYP--- 136
            .:.|. ..:::|..:.:.|: .|:.:::.:.:|.:|..:.:.:..:|....|.:..:   ||
  Rat   128 TMMGT-SILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSMIVTSDTTTWE---YPDVC 188

  Fly   137 --YAALAELAYGPYMSLLVSVLLDLSIFAMAVPSVVMA------------------------AQN 175
              |..    ::|.:.|||.| |:.| |.||.|..|:|:                        :.|
  Rat   189 KHYFG----SFGQWSSLLFS-LVSL-IGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTVLSTN 247

  Fly   176 LEGVVLRMSAGQ----------YN-------FSYCYW-------AIIVGLVICPLMWLGSPKHMR 216
            ....|:..|||.          ||       |.. :|       ..::||:: ||:...||....
  Rat   248 NSSPVICPSAGSGHPDNSSMIFYNSDTEVRLFER-WWDKSKTVPFYLIGLLL-PLLNFKSPSFFS 310

  Fly   217 G---LAIIAVCVMIVIVALL-----------WFC--LFAAPAIGTPFEGISLELPGFLTVLNSYS 265
            .   |..::|..:|.||.|.           ||.  .|..|.|...|.    :|.|.||:
  Rat   311 KFNILGTVSVLYLIFIVTLKAIRLGFHLEFHWFAPTEFFVPEIRAQFP----QLTGVLTL----- 366

  Fly   266 ILAFQFDIHPVLLTLQIDMK-QKSQVSWAALIGIAITCSVAIFGSIIAAYKFGS------MIADN 323
                .|.||..::||..:.| |::.|....:..:.:|.:....|.::.| .|.|      .|..|
  Rat   367 ----AFFIHNCIITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGVLVFA-SFPSPPLPKDCIEQN 426

  Fly   324 LLQSLPTS--VPFYVMLILMALQLCFSVTVASSAMFMQIENYFKLPESLSFKRMLIRSSVLALEV 386
            .|.:.|:|  :.|...:.|:...:.....:...|....:.:.|.......|..:::...::...|
  Rat   427 FLDNFPSSDTLSFIARICLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGV 491

  Fly   387 LVAEFVPSFDALMDVVGGTITGPLVFILPPLLY 419
            .:|.|.|:...::...|.......|||.|.|:|
  Rat   492 TMACFYPNIGGIIRYSGAACGLAFVFIYPSLIY 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mah	NP_651316.1	SLC5-6-like_sbd	110..426	CDD:294310	84/388 (22%)
Slc38a9	NP_001030328.1	SLC5-6-like_sbd	114..555	CDD:382020	92/440 (21%)
Slc38a9	NP_001030328.1	Important for arginine binding and amino acid transport. /evidence=ECO:0000250\|UniProtKB:Q08BA4	128..133		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900