DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmnat and NMA1

DIOPT Version :9

Sequence 1:	NP_651315.2	Gene:	Nmnat / 42987	FlyBaseID:	FBgn0039254	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_013432.1	Gene:	NMA1 / 851039	SGDID:	S000004320	Length:	401	Species:	Saccharomyces cerevisiae

Alignment Length:	261	Identity:	96/261 - (36%)
Similarity:	143/261 - (54%)	Gaps:	24/261 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FKRRSKSKKMSAFIEETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISP 87
            |.....|||:   ::..|  || :..:|||.|||.|.:||||||:|.|....|....|:||..||
Yeast   149 FPSHRLSKKL---LDPNK--LP-LVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSP 207

  Fly    88 THDSYGKKGLASALDRCAMVKLATQ-SSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGG 151
            ..|:|.|:|||.:..|..|.:||.: :|:|:.:..||..|..:.||..||.|..:.||  |..||
Yeast   208 VSDNYQKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSYTRTAKVLDHFNHEIN--IKRGG 270

  Fly   152 GGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITR 216
            .....||               :..|.:.||.|.||:||...|.:||:||:..|:.|:|.:::.|
Yeast   271 VATVTGE---------------KIGVKIMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVER 320

  Fly   217 AGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRL 281
            .||:...|:...||:.:::.||.:|...:.|::|||.:|..:.|..||:|||.:.|:.||:..||
Yeast   321 TGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRAMSVQYLLPNSVIRYIQEHRL 385

  Fly   282 F 282
            :
Yeast   386 Y 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	88/236 (37%)
NMA1	NP_013432.1	NMNAT_Eukarya	166..386	CDD:185681	88/236 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345826
Domainoid	1	1.000	143	1.000	Domainoid score	I998
eggNOG	1	0.900	-	-		E1_COG1057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I1045
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54406
OrthoFinder	1	1.000	-	-		FOG0000967
OrthoInspector	1	1.000	-	-		otm46615
orthoMCL	1	0.900	-	-		OOG6_100907
Panther	1	1.100	-	-	LDO	PTHR12039
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R815
SonicParanoid	1	1.000	-	-		X704
TreeFam	1	0.960	-	-
	14	13.790