back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmnat and NMNAT1

DIOPT Version :9

Sequence 1:	NP_651315.2	Gene:	Nmnat / 42987	FlyBaseID:	FBgn0039254	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001284707.1	Gene:	NMNAT1 / 64802	HGNCID:	17877	Length:	279	Species:	Homo sapiens

Alignment Length:	257	Identity:	116/257 - (45%)
Similarity:	160/257 - (62%)	Gaps:	21/257 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLA 110
            :..:|||.|:|.|.||||:||:|||:....|.:.||.|||||..|:|.||||..|..|..|.:||
Human     9 VVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELA 73

  Fly   111 TQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENT---HLPG----WL-- 166
            |::|.|:.:..||..|.:|..|..||:|||..:.      ....|..:|:   ..||    |.
Human    74 TKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLE------ASDCDHQQNSPTLERPGRKRKWTET 132

  Fly   167 -----PRGLHDSRDPV-HLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFI 225
                 .:.|......| .:|||||||||||||||.||...||..||||:||:.:||||::..|||
Human   133 QDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFI 197

  Fly   226 FDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSK 287
            ::||:|.|::|||.::..|:.|::|||.|||.|.||||::||:.|||.|||::..|::.:|:
Human   198 YESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLYSSESE 259

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.