DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmnat and nmnat3

DIOPT Version :9

Sequence 1:	NP_651315.2	Gene:	Nmnat / 42987	FlyBaseID:	FBgn0039254	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_700826.3	Gene:	nmnat3 / 572070	ZFINID:	ZDB-GENE-070912-331	Length:	249	Species:	Danio rerio

Alignment Length:	248	Identity:	104/248 - (41%)
Similarity:	147/248 - (59%)	Gaps:	29/248 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLA 110
            :..:|||.|:|.|..|:|:||:|:||....|.:|||||||||..|.|||:||.::..|.||.:||
Zfish     7 LVLLACGSFNPITHQHMRLFELARDHMHQTGLYRVVGGIISPVGDGYGKQGLVASKHRLAMARLA 71

  Fly   111 TQSSNWIRLSDWEVHQNQWMRTQAVLQHH------QNYINNHINSGGGGGDDGENTHLPGWLPRG 169
            .|||:|:.:.|||..|..|..|...:::|      |:..|                       :|
Zfish    72 LQSSDWVSVDDWESQQPDWTETVVTMRYHYGRVAAQHCCN-----------------------KG 113

  Fly   170 LHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKY 234
            ...:.|...||||||||.::||.|||||.:..||::|...|||.::|....|.:.|.:||:|:|:
Zfish   114 PPTTSDVPQLKLLCGADFMDSFKVPGLWTDEHIEEVVGRFGLVCVSRGSLQPDRAIHESDLLSKH 178

  Fly   235 QSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSK 287
            :.:|.|:..||.||:|:|.|||.|.||.||||||.|.|:|||:..:|:...|:
Zfish   179 RPSIFLVREWVHNEISATEIRRALRRGHSVKYLLPDSVIEYIREHKLYTQDSE 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	102/241 (42%)
nmnat3	XP_700826.3	NMNAT_Eukarya	7..226	CDD:185681	102/241 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I2902
eggNOG	1	0.900	-	-		E1_COG1057
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39772
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3387
OMA	1	1.010	-	-		QHG54406
OrthoDB	1	1.010	-	-		D1308027at2759
OrthoFinder	1	1.000	-	-		FOG0000967
OrthoInspector	1	1.000	-	-		otm25905
orthoMCL	1	0.900	-	-		OOG6_100907
Panther	1	1.100	-	-	O	PTHR12039
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R815
SonicParanoid	1	1.000	-	-		X704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870