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Protein Alignment Nmnat and NMNAT2

DIOPT Version :9

Sequence 1:	NP_651315.2	Gene:	Nmnat / 42987	FlyBaseID:	FBgn0039254	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_055854.1	Gene:	NMNAT2 / 23057	HGNCID:	16789	Length:	307	Species:	Homo sapiens

Alignment Length:	310	Identity:	106/310 - (34%)
Similarity:	158/310 - (50%)	Gaps:	74/310 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASAL 101
            |.||:   .:..:|||.|:|.|..|::|||.|:|:....|...|:|||:||.||||||:||.|:.
Human     3 ETTKT---HVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSR 64

  Fly   102 DRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQN------------------------- 141
            .|..|.:||.|:|:|||:..||.:|:.|..|.:||:||::
Human    65 HRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQP 129

  Fly   142 --------YINNHINSG-------GGGGDD-----------------GENTHLPGWLPRGLHDSR 174
                    |.|:::.:.       |..|:.                 .||.:| |.:.|     .
Human   130 QNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANL-GTVMR-----Y 188

  Fly   175 DPVHLK--LLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSN 237
            :.:.|:  ||||:||||||.:||||.|||:|.||.:.|:||:.|..::..:.:..|.||.||::|
Human   189 EEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNN 253

  Fly   238 ITLI---TNWVPNEVSSTLIRRLL--GRGQSVKYLLDDLVLEYIKRQRLF 282
            |.::   .|...:.||||..|..|  |.|..|.| |...|::||.:.:|:
Human   254 IMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDY-LSQPVIDYILKSQLY 302

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.