DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssh and SSH2

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001269058.1	Gene:	SSH2 / 85464	HGNCID:	30580	Length:	1450	Species:	Homo sapiens

Alignment Length:	1418	Identity:	405/1418 - (28%)
Similarity:	579/1418 - (40%)	Gaps:	396/1418 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VCSLPDDILIFSLTPRDGESEDDEGNSKGNDRSECFFAGKGTALVLALKDIPPLTQSERRLSTDS 69
            :|...::..||: ...:.:|.::|..|:....||.|...||.||.|           .|...:.:
Human    34 LCCECEESEIFT-DSNEADSGEEECRSQPRSISESFLTVKGAALFL-----------PRGNGSST 86

  Fly    70 TRSSNSTQSNNSDIQLHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTSDRRR 134
            .|.|:....:..|:|.|||:||.||:.||.:::||:|||...|||||:|:.|    .:|..|
Human    87 PRISHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVS----TNGRQD--- 144

  Fly   135 HRIMRHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSGM 199
                                                                            .
Human   145 ----------------------------------------------------------------T 145

  Fly   200 EESCLLGIDCNER----TTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQT 260
            |||.:||:|.:..    .|:|||:|:.:||.|||||||||||....:.||||||||||||||||:
Human   146 EESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQS 210

  Fly   261 LHKVSKKARENNFYASGPSHDWLSSYERRIESDQSCLNEWNAMDALESRRPPSPDAIRNKPPEKE 325
            |||..:.||.:|:|.......|:|.||..|.||||.:||||||..::|.||.||....:.|.|:|
Human   211 LHKACEVARAHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERE 275

  Fly   326 ETESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQMDAPTKIFE 390
            .||.:||.||:.|||..||:.:|||.||..||..:..:|.|:|.|||.||:|||||||:||:|||
Human   276 RTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFE 340

  Fly   391 HVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYI 455
            ||:|||||||||||:||..|||:||||||||||||||.|||.|:||||:|.|:||.||:||:::|
Human   341 HVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFI 405

  Fly   456 TRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS 520
            ::||..|||.|||||||||||||.|||||||.|.|...:|.::||:||:..|||.:|:.|||.|.
Human   406 SKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ 470

  Fly   521 GMLDAMKNK-EKLQRSKSETNLKSTKDARLLPGSEPTPLIQALNQAKSKSTGEAGVTPDGEEEDG 584
            |:|.|.|.: .||.||.|:::|....:....||.|       ||: |..:|     :.|...|..
Human   471 GILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLE-------LNK-KDITT-----SADQIAEVK 522

  Fly   585 SRMHRRSIAQKSQRRMVRRSSSTSPKTQTAVVTKQQSQSMENLTPERSVAEEPKNMRFPGSNGEN 649
            :......|.......||.:.::     |..:.||::...:|..:.|....:....:.....||.:
Human   523 TMESHPPIPPVFVEHMVPQDAN-----QKGLCTKERMICLEFTSREFHAGQIEDELNLNDINGCS 582

  Fly   650 YSVTQNQV------LHIQK------HTPLSVR----TRIHDLE--AHRADQ----LPQQPVWTSL 692
            .....|:.      .|..|      |.|....    ..:.|||  |.:||.    ||.:.:.:.|
Human   583 SGCCLNESKFPLDNCHASKALIQPGHVPEMANKFPDLTVEDLETDALKADMNVHLLPMEELTSPL 647

  Fly   693 TKLITQTSHLGKSVSGSSSGNIDSRRDSSCSDVFSSQVDSV--------FAKDEGEKRQRRKTHS 749
                       |....|......|.:.|..:::.....|.:        |.:...|.|.|..:||
Human   648 -----------KDPPMSPDPESPSPQPSCQTEISDFSTDRIDFFSALEKFVELSQETRSRSFSHS 701

  Fly   750 WTESLGPSGG-------IVLDPTPQQ---QKQQSNAILRPRGTRQRELPSRHASWGSGDNRCCLP 804
            ..|.||  ||       .|::..|.:   ..|:|:::..          :.|||..|..:
Human   702 RMEELG--GGRNESCRLSVVEVAPSKVTADDQRSSSLSN----------TPHASEESSMD----- 749

  Fly   805 QRTSSGSYYDSNRNTTAIFEGVIQDL---KRSSNCNVIEGVAVAVEPI-VGVGEGTVKRTKQKLE 865
                       ...:.||.|.|..|:   ..|.|...::.:...:|.| .|||:..:|
Human   750 -----------EEQSKAISELVSPDIFMQSHSENAISVKEIVTEIESISQGVGQIQLK------- 796

  Fly   866 ESTSLKKRC----QEESQELLLEAVDAGQRRCPSLYRSASS--AHSPRQRQPLRCNSEELMHT-- 922
             ...|...|    :....|||||.....:.:...:.:...|  |.....:....||.|..:.|
Human   797 -GDILPNPCHTPKKNSIHELLLERAQTPENKPGHMEQDEDSCTAQPELAKDSGMCNPEGCLTTHS 860

  Fly   923 --SDIENKNTTPGDHEATVVLRVQGQ----------------TLADDQRI--------------- 954
              :|:|......|:.|      :||.                ||..::|:
Human   861 SIADLEEGEPAEGEQE------LQGSGMHPGAKWYPGSVRRATLEFEERLRQEQEHHGAAPTCTS 919

  Fly   955 ---------SGNVQIL-----------KQNFEAKAGVVGTGGGGGGGTAAGSGSSSTIATSVSAV 999
                     ..:|..|           :.:|..|...:..|.|...|:.|||.|.|....:|.|.
Human   920 LSTRKNSKNDSSVADLAPKGKSDEAPPEHSFVLKEPEMSKGKGKYSGSEAGSLSHSEQNATVPAP 984

  Fly  1000 -------AGACSANPGKKTTSHQS-----------------------LPS-------SPVAQHAN 1027
                   .......||..|.:.|.                       ||.       :.:....|
Human   985 RVLEFDHLPDPQEGPGSDTGTQQEGVLKDLRTVIPYQESETQAVPLPLPKRVEIIEYTHIVTSPN 1049

  Fly  1028 HVSAASNSNSSASNSSDSSVSENCDRNVKGL--VHKYQTTTSCSSQAAATPTVACAPLP------ 1084
            |....|...:|..:........|.:::|..|  :.:....|...:|.:..|.|  .|||
Human  1050 HTGPGSEIATSEKSGEQGLRKVNMEKSVTVLCTLDENLNRTLDPNQVSLHPQV--LPLPHSSSPE 1112

  Fly  1085 --------------PAGTASNISHSCSTTT-----TTSFKQRPLSY------------------- 1111
                          |....|::|.:..|..     ||......|.|
Human  1113 HNRPTDHPTSILSSPEDRGSSLSTALETAAPFVSHTTHLLSASLDYLHPQTMVHLEGFTEQSSTT 1177

  Fly  1112 -------------YDRSLSNRSTHDYSDSR------------------------PPPAPVRVSHS 1139
                         .:..||:.|...|.||:                        |.|...|:.||
Human  1178 DEPSAEQVSWEESQESPLSSGSEVPYKDSQLSSADLSLISKLGDNTGELQEKMDPLPVACRLPHS 1242

  Fly  1140 SNVQHQQQQQQQLQP---EQHQQQVQIRRLAQHGKTHPLSRL----SAPKTGF 1185
            |:.::.:....  .|   ::..::::.|.:.|.|.|.| |::    |..|.|:
Human  1243 SSSENIKSLSH--SPGVVKERAKEIESRVVFQAGLTKP-SQMRRSASLAKLGY 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	104/295 (35%)
		DEK_C	328..379	CDD:285919	26/50 (52%)
		DSPc	385..519	CDD:238073	93/133 (70%)
SSH2	NP_001269058.1	SSH-N	38..263	CDD:212166	106/307 (35%)
		DEK_C	278..329	CDD:285919	26/50 (52%)
		DSPc	335..470	CDD:238073	93/134 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..668		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..711		10/21 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..755		7/57 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..852		3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	867..889		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..981		12/76 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1008		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1068		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1135		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1206		4/34 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2661
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1741
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41938
orthoMCL	1	0.900	-	-		OOG6_104189
Panther	1	1.100	-	-	LDO	PTHR45864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	1	1.000	-	-		X2719
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860