DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssh and DUSP16

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_085143.1	Gene:	DUSP16 / 80824	HGNCID:	17909	Length:	665	Species:	Homo sapiens

Alignment Length:	502	Identity:	130/502 - (25%)
Similarity:	195/502 - (38%)	Gaps:	146/502 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREI--DNFFPGTFEYFNVRVYDDEKTNLLKY 447
            ||:|..::|||.:.:..|.|.:|:||:.::||.:...  .:|.|.: .:..|.|.|.....:|.:
Human   159 PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPES-HFLRVPVNDSFCEKILPW 222

  Fly   448 WDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNF 512
            .|.:..:|.:|||....|||||..|:||||::.|||.||.......:|...||::|..|.||.||
Human   223 LDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNF 287

  Fly   513 LNQLETYSGML------DAMKNKEKLQR---------------SKSETNL------KSTKDAR-- 548
            |.||..|...:      ...|:|.||..               .||||.|      .:|.:|.
Human   288 LGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSPPCADSATSEAAGQ 352

  Fly   549 --LLPGSEP------------TPLIQAL-------------NQAKS------KSTG-----EAGV 575
              :.|.|.|            :||:|||             |:.|.      ||..     .|.:
Human   353 RPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAASL 417

  Fly   576 TPDGEEEDGSRMHRRSIAQKSQRRMVR---------RSSSTSP---------KTQTAVVTKQQSQ 622
            ......||....::.|.......::.:         ::..|||         |.|||..:..||:
Human   418 HGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSK 482

  Fly   623 SMENL------TPERSVAEEPKNMRFPGSNGENYSV-------TQNQVLHIQKHTPLSVRTRIHD 674
            .:.::      |.:||:...   :...||..:||..       |..|  |:.|...|.::....|
Human   483 RLHSVRTSSSGTAQRSLLSP---LHRSGSVEDNYHTSFLFGLSTSQQ--HLTKSAGLGLKGWHSD 542

  Fly   675 LEAHRADQLPQ--QPVWTSLTKLITQTSHL--GKSVSGSSSGNIDSRRDSSCSDV--FSSQVDSV 733
            :.|      ||  .|..||.....|::||.  ..::.|.|:    |....|||.:  ...||.||
Human   543 ILA------PQTSTPSLTSSWYFATESSHFYSASAIYGGSA----SYSAYSCSQLPTCGDQVYSV 597

  Fly   734 FAKDEGEKRQRRK-------THSWTESLGPSGGIVLDPTPQQQKQQS 773
                    |:|:|       ..||.|.         .|..:|.|::|
Human   598 --------RRRQKPSDRADSRRSWHEE---------SPFEKQFKRRS 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166
		DEK_C	328..379	CDD:285919
		DSPc	385..519	CDD:238073	51/135 (38%)
DUSP16	NP_085143.1	DSP_MapKP	10..136	CDD:238723
		DSPc	158..295	CDD:238073	51/136 (38%)
		CDC14	<207..300	CDD:225297	37/92 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..368		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..505		12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..665		11/48 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850