DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssh and Dusp16

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_569714.2	Gene:	Dusp16 / 70686	MGIID:	1917936	Length:	660	Species:	Mus musculus

Alignment Length:	511	Identity:	132/511 - (25%)
Similarity:	198/511 - (38%)	Gaps:	169/511 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREI--DNFFPGTFEYFNVRVYDDEKTNLLKY 447
            ||:|..::|||.:.:..|.:.:|:||:.::||.:...  .:|.|.: .:..|.|.|.....:|.:
Mouse   159 PTRILPNLYLGCQRDVLNKDLMQQNGIGYVLNASNTCPKPDFIPES-HFLRVPVNDSFCEKILPW 222

  Fly   448 WDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNF 512
            .|.:..:|.:|||....||:||..|:||||::.|||.||.......:|...||::|..|.||.||
Mouse   223 LDKSVDFIEKAKASNGCVLIHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNF 287

  Fly   513 LNQLETY-------SGMLDAMKNKEKLQRS---------------KSETNL-----KSTKDA--- 547
            :.||..|       :|| ...|:|.||...               ||..:|     .||.:|
Mouse   288 MGQLMDYEKTINNQTGM-SGPKSKLKLLHLDKPSEPVPAASEGGWKSALSLSPPCANSTSEASGQ 351

  Fly   548 RLL-PGSEP---------TPLIQALNQAKSKSTGEAGVTPDGEE-EDGSRMHRR-SIAQKSQRRM 600
            ||: |.|.|         :||:|||          :|:....|: ||.:::.|. |:..||....
Mouse   352 RLVHPASVPSLQPSLLEDSPLVQAL----------SGLQLSSEKLEDSTKLKRSFSLDIKSVSYS 406

  Fly   601 VRRSSS---------------------TSPKTQTAVVTKQQSQSMENLTPERSVAEEPKNMRFP- 643
            ...::|                     |:...|.:.|.:...||.|. :|::..|..||..:.|
Mouse   407 ASMAASLHGFSSEEALDYYKPSATLDGTNKLCQFSPVQEVSEQSPET-SPDKEEAHIPKQPQPPR 470

  Fly   644 --------------GSNG-----------------ENYSV-------TQNQVLHIQKHTPLSVRT 670
                          ||:|                 :||..       |..|  |:.|...|.::.
Mouse   471 PSESQVTRLHSVRTGSSGSTQRPFFSPLHRSGSVEDNYHTNFLFGLSTSQQ--HLTKSAGLGLKG 533

  Fly   671 RIHDLEAHRADQLPQQ--PVWTSLTKLITQTSHL---------GKSVSGSSSGNIDSRRDSSCSD 724
            ...|:.|      ||.  |..||.....|:.|||         ..|.|..|.|.:     .:|||
Mouse   534 WHSDILA------PQSSAPSLTSSWYFATEPSHLYSASAIYGGNSSYSAYSCGQL-----PTCSD 587

  Fly   725 VFSSQVDSVFAKDEGEKRQRRK-------THSWTESLGPSGGIVLDPTPQQQKQQS 773
                |:.||        |:|:|       ..||.|.         .|..:|.|::|
Mouse   588 ----QIYSV--------RRRQKPTDRADSRRSWHEE---------SPFEKQFKRRS 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166
		DEK_C	328..379	CDD:285919
		DSPc	385..519	CDD:238073	48/135 (36%)
Dusp16	NP_569714.2	DSP_MapKP	10..136	CDD:238723
Dusp16	NP_569714.2	PTP_DSP_cys	157..301	CDD:421693	49/142 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850