DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssh and Dusp12

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_071584.1	Gene:	Dusp12 / 64014	RGDID:	68375	Length:	339	Species:	Rattus norvegicus

Alignment Length:	221	Identity:	64/221 - (28%)
Similarity:	102/221 - (46%)	Gaps:	29/221 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 VYLGSEWNASNLEELQKNGVRHILNVTRE----IDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTF 452
            :|||.....:..:.|::.|:..:|.|..|    ....|.|....| |...|..:|:||.:.|...
  Rat    34 LYLGGAAAVAGPDYLREAGITAVLTVDSEPAFPAGAGFEGLQSLF-VPALDKPETDLLSHLDRCV 97

  Fly   453 RYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLE 517
            .:|.:|::||..|||||..|||||.:||.|:.||..|..|::|.|:::..:...|.|:.|..||:
  Rat    98 AFIGQARSEGRAVLVHCHAGVSRSVAVVTAFIMKTEQLTFEKAYENLQTIKPEAKMNEGFEWQLK 162

  Fly   518 TYSGMLDAMKNKEKLQRSKSETNLKSTKDARLLPGSEPTPLIQALNQ---AKSKSTGEAGVTPDG 579
            .|..|           ..:..|:....|..||...:|..|.::.|.:   |...:|...|:..|
  Rat   163 LYEAM-----------GHEVHTSSAVYKQYRLQKVTEKYPELRNLPRELFAVDPTTVSQGLKDD- 215

  Fly   580 EEEDGSRMHRRSIAQKSQRRMVRRSS 605
                  .:::   .:|.:|.:.||||
  Rat   216 ------ILYK---CRKCRRSLFRRSS 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166
		DEK_C	328..379	CDD:285919
		DSPc	385..519	CDD:238073	45/130 (35%)
Dusp12	NP_071584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		DSPc	26..165	CDD:238073	45/131 (34%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UNI6	115..120		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810