DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssh and MKP-4

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001259717.1	Gene:	MKP-4 / 32963	FlyBaseID:	FBgn0031044	Length:	387	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	71/270 - (26%)
Similarity:	123/270 - (45%)	Gaps:	62/270 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 VYLGSEWNASNLEELQKNGVRHILNVTREIDNF-FPG--------TFEYFNVRVYDDEKTNLLKY 447
            ::||:...|:::|.|:...:.|||.    :|:. .|.        |.:|  :::.|..:.::|::
  Fly    46 LFLGNLTAATHMETLRSFKITHILT----LDSVPLPQHILEASFLTTKY--IQIADMPREDILQH 104

  Fly   448 WDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNF 512
            .:....:|:.|.|:...|||||..|||||:|.||||.||.:..:|..|.|.||.:|..::||..|
  Fly   105 LEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGF 169

  Fly   513 LNQLETYSGM---LDAMKNKEKLQRSKSETNLKSTKDARLLPGS--------------EPTPLI- 559
            ::||:.:..|   :|....:.|:.|.:...  :..:.|::||.|              .|.|::
  Fly   170 VSQLKLFRRMGCKIDPNCQRYKIHRLRLAG--EQMRKAKILPQSFHSVVRPDPDITRENPEPIVF 232

  Fly   560 ------------QALNQAKSKSTGEAGVTPDGEEE-----------DGSRMHR--RSIAQKSQRR 599
                        ..:.:.|.:......|.|..:||           |.:..|.  |.:.|.|:|
  Fly   233 RCRRCRRVLASKSHVLEHKPRDRPPQEVVPKEKEEVAAAKLPAQSHDQAENHHGARMLEQLSER- 296

  Fly   600 MVRRSSSTSP 609
             :|:||..||
  Fly   297 -IRQSSLGSP 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166
		DEK_C	328..379	CDD:285919
		DSPc	385..519	CDD:238073	45/135 (33%)
MKP-4	NP_001259717.1	DSPc	39..176	CDD:238073	45/135 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I2226
eggNOG	1	0.900	-	-		E2759_KOG1716
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810