DRSC/TRiP Functional Genomics Resources

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Protein Alignment ssh and Ssh3

DIOPT Version :10

Sequence 1:NP_733063.1 Gene:ssh / 42986 FlyBaseID:FBgn0029157 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_001361616.1 Gene:Ssh3 / 245857 MGIID:2683546 Length:653 Species:Mus musculus


Alignment Length:685 Identity:238/685 - (34%)
Similarity:337/685 - (49%) Gaps:148/685 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 GESEDDEGNSKGN-DRSECFFAGKGTAL---------VLALKDIPPLTQ--SERRLSTDSTRSSN 74
            |.::|.....:|. .|.:.|...:|..|         |.:..|..|:.:  .|.:.:.|.|....
Mouse    20 GPTQDRVVRRRGRLQRRQSFAVLRGAVLGLQDGGDSNVASEADSEPMEEPSGEEQPTEDQTDKGQ 84

  Fly    75 STQSNNSDIQ-LHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTSDRRRHRIM 138
            ..||....:| .||..|..||:.:|.:::|.:||:.|..|.|||::.|                 
Mouse    85 GLQSPWKQVQKRHLHLMVELLRPQDDIRLAAQLEAARPPRLRYLLVVS----------------- 132

  Fly   139 RHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSGMEESC 203
                                  |..:||                                 ||:.
Mouse   133 ----------------------TGEELS---------------------------------EEAI 142

  Fly   204 LLGID----CNERTTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQTLHKV 264
            |||:|    .:...|:|||:|:.:||.::|||||||||....::.||||||:|.||:.||.||:.
Mouse   143 LLGVDFPDSSSHSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQA 207

  Fly   265 SKKARENNFYASGPSHDWLSSYERRIESDQSCLNEWNAMDALESRRPPS--PDAIRNKPPEKEET 327
            .:.|..:.....|.:..|.:.|:.::.|||.|||||.||..|||.|||:  |..|..:..|:|:.
Mouse   208 CEVALGSGLVPGGSALAWATYYQEKLNSDQGCLNEWMAMSDLESFRPPNAEPGQITTRASEQEKM 272

  Fly   328 ESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQMDAPTKIFEHV 392
            |..|..:|..::.:.|||.||||.||..||..|...|.:|:.|||.:||:::.|.|..::||.|:
Mouse   273 EQAILAELWQVLDTSDLDSVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHL 337

  Fly   393 YLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITR 457
            ||||||||:||||||||.|.||||:.||||||||..|.|:||||:|:|...||.:|.:|.|:|..
Mouse   338 YLGSEWNAANLEELQKNRVSHILNMAREIDNFFPERFTYYNVRVWDEESAQLLPHWKETHRFIED 402

  Fly   458 AKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM 522
            |:|:|::|||||||||||||:.|:|||||.|.|:.:|||.||::.|..::||..||.||.||.|:
Mouse   403 ARAQGTRVLVHCKMGVSRSAATVLAYAMKQYGWDLEQALIHVQELRPIVRPNHGFLRQLRTYQGI 467

  Fly   523 LDAMKN----KEKLQRSKSETNLKSTKDARLLP-----------------GSEPTP--------- 557
            |.|.:.    ::|:.....|..|.......|.|                 ||:.||         
Mouse   468 LTASRQSHVWEQKVGVVSPEEPLAPEVSTPLPPLPPEPGGSGEVMVMGLEGSQETPKEELGLRPR 532

  Fly   558 --------LIQALNQAKSKSTGEAGVTPDGEEEDGSRMH---RRSIAQKSQRRMVRRSSSTSPKT 611
                    .|..|..::|:||.|||..|:....|...:|   :.|.|:..||  ||:....:.|:
Mouse   533 INLRGVMRSISLLEPSESESTPEAGGLPEVFSSDEEPLHPFSQLSRAKGGQR--VRKGPWPALKS 595

  Fly   612 QTAVVT--------------KQQSQSMENLTPERS 632
            :.:||.              ::|.|..|...|..|
Mouse   596 RQSVVALHSAALVASRTRAFQEQGQGQEQSEPGMS 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sshNP_733063.1 SSH-N 21..313 CDD:212166 88/307 (29%)
DEK_C 326..379 CDD:462592 22/52 (42%)
DSP_slingshot 385..523 CDD:350363 85/137 (62%)
Ssh3NP_001361616.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 2/11 (18%)
SSH-N 3..256 CDD:212166 88/307 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..90 8/40 (20%)
DEK_C 273..324 CDD:462592 22/50 (44%)
DSP_slingshot_3 327..470 CDD:350419 87/142 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..590 16/46 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..653 5/19 (26%)

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