DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssh and Ssh3

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_001361616.1	Gene:	Ssh3 / 245857	MGIID:	2683546	Length:	653	Species:	Mus musculus

Alignment Length:	685	Identity:	238/685 - (34%)
Similarity:	337/685 - (49%)	Gaps:	148/685 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GESEDDEGNSKGN-DRSECFFAGKGTAL---------VLALKDIPPLTQ--SERRLSTDSTRSSN 74
            |.::|.....:|. .|.:.|...:|..|         |.:..|..|:.:  .|.:.:.|.|....
Mouse    20 GPTQDRVVRRRGRLQRRQSFAVLRGAVLGLQDGGDSNVASEADSEPMEEPSGEEQPTEDQTDKGQ 84

  Fly    75 STQSNNSDIQ-LHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTSDRRRHRIM 138
            ..||....:| .||..|..||:.:|.:::|.:||:.|..|.|||::.|
Mouse    85 GLQSPWKQVQKRHLHLMVELLRPQDDIRLAAQLEAARPPRLRYLLVVS----------------- 132

  Fly   139 RHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSGMEESC 203
                                  |..:||                                 ||:.
Mouse   133 ----------------------TGEELS---------------------------------EEAI 142

  Fly   204 LLGID----CNERTTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQTLHKV 264
            |||:|    .:...|:|||:|:.:||.::|||||||||....::.||||||:|.||:.||.||:.
Mouse   143 LLGVDFPDSSSHSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQA 207

  Fly   265 SKKARENNFYASGPSHDWLSSYERRIESDQSCLNEWNAMDALESRRPPS--PDAIRNKPPEKEET 327
            .:.|..:.....|.:..|.:.|:.::.|||.|||||.||..|||.|||:  |..|..:..|:|:.
Mouse   208 CEVALGSGLVPGGSALAWATYYQEKLNSDQGCLNEWMAMSDLESFRPPNAEPGQITTRASEQEKM 272

  Fly   328 ESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQMDAPTKIFEHV 392
            |..|..:|..::.:.|||.||||.||..||..|...|.:|:.|||.:||:::.|.|..::||.|:
Mouse   273 EQAILAELWQVLDTSDLDSVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHL 337

  Fly   393 YLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITR 457
            ||||||||:||||||||.|.||||:.||||||||..|.|:||||:|:|...||.:|.:|.|:|..
Mouse   338 YLGSEWNAANLEELQKNRVSHILNMAREIDNFFPERFTYYNVRVWDEESAQLLPHWKETHRFIED 402

  Fly   458 AKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM 522
            |:|:|::|||||||||||||:.|:|||||.|.|:.:|||.||::.|..::||..||.||.||.|:
Mouse   403 ARAQGTRVLVHCKMGVSRSAATVLAYAMKQYGWDLEQALIHVQELRPIVRPNHGFLRQLRTYQGI 467

  Fly   523 LDAMKN----KEKLQRSKSETNLKSTKDARLLP-----------------GSEPTP--------- 557
            |.|.:.    ::|:.....|..|.......|.|                 ||:.||
Mouse   468 LTASRQSHVWEQKVGVVSPEEPLAPEVSTPLPPLPPEPGGSGEVMVMGLEGSQETPKEELGLRPR 532

  Fly   558 --------LIQALNQAKSKSTGEAGVTPDGEEEDGSRMH---RRSIAQKSQRRMVRRSSSTSPKT 611
                    .|..|..::|:||.|||..|:....|...:|   :.|.|:..||  ||:....:.|:
Mouse   533 INLRGVMRSISLLEPSESESTPEAGGLPEVFSSDEEPLHPFSQLSRAKGGQR--VRKGPWPALKS 595

  Fly   612 QTAVVT--------------KQQSQSMENLTPERS 632
            :.:||.              ::|.|..|...|..|
Mouse   596 RQSVVALHSAALVASRTRAFQEQGQGQEQSEPGMS 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	88/307 (29%)
		DEK_C	328..379	CDD:285919	22/50 (44%)
		DSPc	385..519	CDD:238073	82/133 (62%)
Ssh3	NP_001361616.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		2/11 (18%)
		SSH-N	3..256	CDD:212166	88/307 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..90		8/40 (20%)
		DEK_C	273..324	CDD:370106	22/50 (44%)
		DSP_slingshot_3	327..470	CDD:350419	87/142 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..590		16/46 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..653		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1965
Isobase	1	0.950	-	0	Normalized mean entropy	S4509
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	1	1.000	-	-		FOG0002581
OrthoInspector	1	1.000	-	-		otm43985
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.910