Protein Alignment ssh and Ssh2

DIOPT Version :10

• Sequence 1: NP_733063.1
• Gene: ssh / 42986
• FlyBaseID: FBgn0029157
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_006533290.1
• Gene: Ssh2 / 237860
• MGIID: 2679255
• Length: 1450
• Species: Mus musculus
• Alignment Length: 1409
• Identity: 403/1409 - (28%)
• Similarity: 572/1409 - (40%)
• Gaps: 409/1409 - (29%)

  Fly    21 DGESEDDEGNSKGNDRSECFFAGKGTALVLALKDIPPLTQSERRLSTDSTRSSNSTQSNNSDIQL 85
            :.:|.::|..|:....||.|...||.||.|           .|...:.:.|.|:....:..|:|.
Mouse    49 EADSGEEECRSQPRSISESFLTVKGAALFL-----------PRGNGSSTPRVSHRRNKHAGDLQQ 102

  Fly    86 HLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTSDRRRHRIMRHHSVKVGGSAG 150
            |||:||.||:.||.:::||:|||...|||||:|:.|    .:|..|
Mouse   103 HLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVS----TNGRQD------------------- 144

  Fly   151 TKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSGMEESCLLGIDCNER--- 212
                                                            .|||.:||:|.:..
Mouse   145 ------------------------------------------------TEESIVLGMDFSSNDSS 161

  Fly   213 -TTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQTLHKVSKKARENNFYAS 276
             .|:|||:|:.:||.|||||||||||....:.||||||||||||||||:|||..:.||.:|:|..
Mouse   162 TCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARMHNYYPG 226

  Fly   277 GPSHDWLSSYERRIESDQSCLNEWNAMDALESRRPPSPDAIRNKPPEKEETESVIKMKLKAIMMS 341
            .....|:|.||..|.||||.:||||||..::|.||.||....:.|.|:|.||.:||.||:.|||.
Mouse   227 SLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQ 291

  Fly   342 VDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQMDAPTKIFEHVYLGSEWNASNLEEL 406
            .||:.:|||.||..||..:..:|.|:|.|||.||:|||||||:||:|||||:|||||||||||:|
Mouse   292 KDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDL 356

  Fly   407 QKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKM 471
            |..|||:||||||||||||||.|||.|:||||:|.|:||.||:||:::|::||..|||.||||||
Mouse   357 QNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKM 421

  Fly   472 GVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAMKNK-EKLQRS 535
            |||||||.|||||||.|.|...:|.::||:||:..|||.:|:.|||.|.|:|.|.|.: .||.||
Mouse   422 GVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWRS 486

  Fly   536 KSETNLKSTKDARLLPGSE--PTPLIQALNQAKSKSTGE----------AGVTPDGEEEDGSRMH 588
            .|:::|....:....||.|  ...:..:.:|.....|.|          ..|.|....:.|....
Mouse   487 HSDSDLSDHHEPICKPGLELNKKEMTTSADQIAEVKTVENLAAMPTVFMEHVVPQDANQKGLHTK 551

  Fly   589 RRSIAQKSQRRMVRR---------------------SSSTSP----KTQTAVVTKQQSQSMENLT 628
            .|.|..:...:..|.                     |.|..|    ....|::...|:..:.|..
Mouse   552 ERVICLEFSSQEFRAGQIEDELNLNDINGCSSGCCLSESKLPLDNCHASKALLQPGQAPDIANKF 616

  Fly   629 PERSVAEEPKNMRFPGSNGENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQQPVWTSLT 693
            |:.:|.:.           |..::..:..:|:.....|:.|.:          .||..|   .|.
Mouse   617 PDLAVEDL-----------ETDALKADMNVHLLPMEELTSRLK----------DLPMSP---DLE 657

  Fly   694 KLITQTSHLGKSVSGSSSGNIDSRRDSSCSDVFSSQVDSVFAKDEGEKRQRRKTHSWTESLGPSG 758
            ....|.| ...::|..|:..||          |.|.::. |.:...|.|.|..:||..|.||  |
Mouse   658 SPSPQAS-CQAAISDFSTDRID----------FFSALEK-FVELSQETRSRSFSHSRIEELG--G 708

  Fly   759 GIVLDPTPQQQKQQSNAILRPRGTRQRELPSRHASWGSGDNRCCLPQRT---SSGSYYDSNRNTT 820
            |                  |..|.|...:....:...:.|.|......|   |..|..|.:: :.
Mouse   709 G------------------RSEGCRLSVIEVAASEMAADDQRSSSLSNTPHASEESSVDEDQ-SK 754

  Fly   821 AIFEGVIQDL---KRSSNCNVIEGVAVAVEPI-VGVGEGTVKRTKQKLEESTSLKKRCQEESQ-- 879
            ||.|.|..|:   ..|.|...::.:...:|.| .|||:..:|        ...|...|....:
Mouse   755 AITELVSPDIIMQSHSENAISVKEIVTEIESISQGVGQVQLK--------GDILSNPCHTPKKST 811

  Fly   880 --ELLLEAVDAGQRRCPSLY---RSASSAHSPRQRQPLRCNSEE---LMH--TSDIENKNTTPGD 934
              ||.||.|.|.:.: |..:   .|..|......|...:|..||   ..|  |:|:|.:....|:
Mouse   812 IHELPLERVPAPESK-PGHWEQDESFCSVQPELARDSGKCAPEEGCLTTHSSTADLEEEEPVEGE 875

  Fly   935 HE------------------ATVV----LRVQ---------GQTLADDQRISGNVQIL------- 961
            |:                  ||:.    ||.:         |.||::.:....:..:.
Mouse   876 HDWGPGMHSGAKWCPGSVRRATLEFEERLRQEQENHGTASAGPTLSNRKNSKNDSSVADLMPKWK 940

  Fly   962 ------KQNFEAKAGVVGTGGGGGGGTAAGSGSSSTIATSVSAVAGACSANPGK---KTTSHQSL 1017
                  :.:|..|......|.|...|:.|||.|.             |..||..   :...|.||
Mouse   941 SDETTPEHSFFLKEAEPSKGKGKCSGSEAGSLSH-------------CERNPTMPDCELLEHHSL 992

  Fly  1018 PS------------------------------------------------SPVAQHANHVSAASN 1034
            |:                                                :|......|......
Mouse   993 PAPQDCLGSDSRSKKQEGDLKKQRAVVPNQECDTQAILLPLPKKIEIIEYTPTVTSLGHTEPGGE 1057

  Fly  1035 SNSSASNSS--------DSSVSENC--DRNVKGLVHKYQ------------TTTSCSSQA----- 1072
            :..|.....        :.|::..|  |.|:...:...|            :::.|...|
Mouse  1058 ATPSKEGEKQGLRKVKMEQSITMFCALDENLNRTLEPSQVSLHPQVLPLPHSSSECDRPADPNPM 1122

  Fly  1073 ----------------AATPTVACAP----------LP------------PAGTASNIS------ 1093
                            .|.|.|:|:.          ||            .:.|.:.:|
Mouse  1123 LSSPQDKGDCPSTPFKTAAPFVSCSTQGASFSLDYLLPHSVVHLEGCTEQSSATDNELSPEQASW 1187

  Fly  1094 -----HSCSTTTTTSFKQRPLSYYDRSLSNRSTHDYSDS--------RPPPAPVRVSHSSNVQH- 1144
                 |..|:.:..:....||:..|.||.|:    ..||        .|.|...|:.|||:.::
Mouse  1188 EDSRGHFLSSGSGMAHTSSPLTNEDLSLINK----LGDSVGVLQKKLDPSPEACRIPHSSSSENI 1248

  Fly  1145 QQQQQQQLQPEQHQQQVQIRRLAQHG--KTHPLSR-LSAPKTGF 1185
            :.....:...::|.::::.|.:.|.|  ||..:.| .|..|.|:
Mouse  1249 RDLSHSRGVVKEHAKEIESRVIFQAGFSKTSQMKRSASLAKLGY 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	104/295 (35%)
		DEK_C	326..379	CDD:462592	27/52 (52%)
		DSP_slingshot	385..523	CDD:350363	95/137 (69%)
Ssh2	XP_006533290.1	SSH-N	40..263	CDD:212166	104/295 (35%)
		DEK_C	277..329	CDD:462592	27/51 (53%)
		DSP_slingshot_2	332..475	CDD:350417	98/142 (69%)