Protein Alignment ssh and Ssh1

DIOPT Version :10

• Sequence 1: NP_733063.1
• Gene: ssh / 42986
• FlyBaseID: FBgn0029157
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_011246495.1
• Gene: Ssh1 / 231637
• MGIID: 2686240
• Length: 1073
• Species: Mus musculus
• Alignment Length: 1213
• Identity: 360/1213 - (29%)
• Similarity: 510/1213 - (42%)
• Gaps: 324/1213 - (26%)

  Fly    37 SECFFAGKGTALVLALKDIPPLTQSERRLSTDSTRSSNSTQSNNSDIQLHLQSMFYLLQREDTLK 101
            ||.||..||.||.|           ::..|....||......:..|:..|||.|..||:.||.:|
Mouse    70 SESFFMVKGAALFL-----------QQGNSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRIK 123

  Fly   102 MAVKLESQRSNRTRYLVIASRSCCRSGTSDRRRHRIMRHHSVKVGGSAGTKSSTSPAVPTQRQLS 166
            :||:|||..::|.||:|:.    ..||..|
Mouse   124 LAVRLESVWTDRVRYMVVV----YTSGRQD----------------------------------- 149

  Fly   167 VEQTATEASSKCDKTADKENATAAGDNKNTSGMEESCLLGIDCNER----TTIGLVVPILADTTI 227
                                            .||:.|||:|.:.:    .|||:|:.:.:||.|
Mouse   150 --------------------------------TEENILLGVDFSSKESKSCTIGMVLRLWSDTKI 182

  Fly   228 HLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQTLHKVSKKARENNFYASGPSHDWLSSYERRIES 292
            ||||||||||....:.||||||||||||||||.|||..:.||.:|::..|.:..|.:.||..|.|
Mouse   183 HLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISS 247

  Fly   293 DQSCLNEWNAMDALESRRPPSPDAIRNKPPEKEETESVIKMKLKAIMMSVDLDEVTSKYIRGRLE 357
            :|||:||||||..|||.||.||....:||.|.|.||.:||.||::||||.||:.||||.||..||
Mouse   248 EQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELE 312

  Fly   358 EILDMDLGEYKSFIDAEMLVILGQMDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREID 422
            :.::.:|.|:|.|||.|||:||||||.|:.||:|:|||||||||||||||.:||.:|||||||||
Mouse   313 KQMNCNLKEFKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREID 377

  Fly   423 NFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKA 487
            |||||.|.|.|:||||:|.|:||.:|::.:.:|.:||...||.|||||||||||||.|||||||.
Mouse   378 NFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKE 442

  Fly   488 YQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAMK---NKEKLQRSKSET---------- 539
            :.|..::|..:||::||..:||..|:.||..|.|:|||.|   ||...|:...:|
Mouse   443 FGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQPTDDTIAEPSEFLPE 507

  Fly   540 NLKSTKDAR---------------LLPGSEPTPLIQALNQAKSKSTGEAGVTPDGEEEDGSRMHR 589
            .|....||:               |.||....|..       .:...:..:.|. .:|.|..:|.
Mouse   508 TLDGALDAQLPCLDDTTHPGLPRSLAPGGPALPCC-------FRRLSDPLLLPH-HDETGGLVHL 564

  Fly   590 RSIAQKSQRRMVRRSSSTSPKTQTAVVTKQQSQSMENLTPERSVAEEP------------KNMRF 642
            ..:                  .:.|::.:::||.:|    ...:.:.|            :.:.|
Mouse   565 EDL------------------EKDALLEEEESQPVE----VHKLVQHPQEGARLCEKDVKRKLEF 607

  Fly   643 PGSNGENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQQPVW----TSLTKLITQTSHLG 703
            ..|...:.|:.|                 :.:||   .|..|:...|    |.|.:.:....:|.
Mouse   608 GNSKPRSDSLPQ-----------------VEELE---KDGSPRTGRWRRASTQLDRSLLDQENLN 652

  Fly   704 KSVSGSSSGNIDSRRD------SSCSDVFSSQVDSVFAKDEGEKRQRRKTHSWTESLGP-SGGIV 761
            .:.|..|..: |..||      |.....::|..|.::....|......:.|.     .| |..|.
Mouse   653 NNNSKRSCPD-DLERDAMFGILSKVKPPYTSCADCMYPTAGGTPEAYMERHE-----DPSSSAIC 711

  Fly   762 LDPTPQQQKQQSNAILRPRGTRQRELPSRHASWGSGDNRCCLPQRTSSGSYYDSNRNTTAIFEGV 826
            ..||           ..|..|..   |..|||     :|...|:|.:||   .:|.:...:..|.
Mouse   712 TQPT-----------FLPHVTSS---PMAHAS-----SRSRAPERPASG---PANTSPFLLPAGS 754

  Fly   827 IQ-DLKRSSNCNVIEGVAVAVEPIVGVGEGTVKRTKQKLEESTSLKK-RCQEESQELLLEA-VDA 888
            .: |:..|       |...|.||...:.|.: :.|.:.|.:|..||. .|.:.:..:.:.| .:.
Mouse   755 RKPDVSGS-------GAGAAPEPPASLLEPS-RETSKALPKSLQLKNPHCDKNAANMEVSAKEEP 811

  Fly   889 GQRRCPSLYRS-----ASSAHSPRQRQPLRCNSEELM----------HTSDIENKNTTPGDHEAT 938
            ..::.|...:.     ::.|..|.....|..:.|.::          ||.::|...:.|.|..|.
Mouse   812 SPKKDPKPAKDLRLLFSNEAEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSLPSDSPAA 876

  Fly   939 VVLRVQGQTLADDQRISGNVQILKQNFEAKAGVVGTGGGGGGGTAAGSGSSSTIATSVSAVAGAC 1003
            .             |.|...::     ||.....|:.........:.:||..      ..|.|..
Mouse   877 C-------------RDSATCRL-----EASIPEEGSQEPAHPALCSQAGSEE------QPVGGTL 917

  Fly  1004 SANPGKKTTSHQSLPSSPVAQHANH-------------VSAASNSNSSASNSSDSSVSENCDRNV 1055
            ..:|    ||     :.|...|.::             .|::.:||.:.|:||||..|.   |..
Mouse   918 QKSP----TS-----TLPRLDHTSNFSKDFLKTVCYTPTSSSISSNLTRSSSSDSIHSV---RGK 970

  Fly  1056 KGLVHKYQTTTSCSSQAAATPTVACAPLPPAGTASNISHSCSTTTTTSFKQRPLSYYDRSLSNRS 1120
            .|||.  |......::.........:||       ..|||.:...:.:|....||      |...
Mouse   971 PGLVK--QRAQEIETRLRLAGLTVSSPL-------KRSHSLAKLGSLNFSTEDLS------SEAD 1020

  Fly  1121 THDYSDS-------------------RPPPAPVRVSHSSNVQH 1144
            |...:||                   |.|.|..:.|..|..:|
Mouse  1021 TSTIADSQDAKCGLSSSFLPEPQSAPRDPAATSKSSGKSAPEH 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	99/279 (35%)
		DEK_C	326..379	CDD:462592	29/52 (56%)
		DSP_slingshot	385..523	CDD:350363	85/137 (62%)
Ssh1	XP_011246495.1	SSH-N	65..268	CDD:212166	99/279 (35%)
		DEK_C	282..334	CDD:462592	29/51 (57%)
		DSP_slingshot_1	337..480	CDD:350418	88/142 (62%)
		PTZ00449	<689..1068	CDD:185628	91/461 (20%)