Protein Alignment ssh and DUSP8

DIOPT Version :10

• Sequence 1: NP_733063.1
• Gene: ssh / 42986
• FlyBaseID: FBgn0029157
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_004411.2
• Gene: DUSP8 / 1850
• HGNCID: 3074
• Length: 625
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 125/562 - (22%)
• Similarity: 193/562 - (34%)
• Gaps: 147/562 - (26%)

  Fly   386 TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDN-FFPGTFEYFNVRVYDDEKTNLLKYWD 449
            |:|..|:||||:.:..|.:.:.:||:.::||.:..... .|.....:..|.:.|:....||.:.|
Human   162 TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLD 226

  Fly   450 DTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLN 514
            .:..:|.:||....:|:|||..|:||||::.|||.||........|...||.||..|.||.|||.
Human   227 KSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLG 291

  Fly   515 QLETYSGMLDAMKNKEKLQRSKSETNLKSTKDARLLPGSEPTPLIQALNQAKSKSTGEAGVTPDG 579
            ||..|...|..:...:....:.|.|           |...|:|...|........|.|:..|.:.
Human   292 QLLEYERSLKLLAALQGDPGTPSGT-----------PEPPPSPAAGAPLPRLPPPTSESAATGNA 345

  Fly   580 EEEDGSRMHRRSIAQKSQRRMVRRSSSTSPKTQTAVVTKQQSQSMENLTPERSVAEEPKNMRFPG 644
            ...:|.              :.......:|.|..|....||.....:|:.:          |...
Human   346 AAREGG--------------LSAGGEPPAPPTPPATSALQQGLRGLHLSSD----------RLQD 386

  Fly   645 SNGENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQQP------VWTSLTKLITQTSHLG 703
            :|            .:::...|.:::      |:...:.|..|      ....|.||
Human   387 TN------------RLKRSFSLDIKS------AYAPSRRPDGPGPPDPGEAPKLCKL-------- 425

  Fly   704 KSVSGSSSGNIDSRRDSSCSDVFSSQVDSVFAKDEGEKRQRRK--------THSWTESLGPSGGI 760
            .|.||::.|            :.|...||..|..|...|.||:        ..|...|||.:.|
Human   426 DSPSGAALG------------LSSPSPDSPDAAPEARPRPRRRPRPPAGSPARSPAHSLGLNFG- 477

  Fly   761 VLDPTPQQQKQQSNAILRPRGTRQRELPSRHASWG---------SGDNRCCLPQRTSSGSYYDSN 816
              |...|..:...:|:..| |......|:...:|.         |.|...|.....:.|:
Human   478 --DAARQTPRHGLSALSAP-GLPGPGQPAGPGAWAPPLDSPGTPSPDGPWCFSPEGAQGA----- 534

  Fly   817 RNTTAIFEGVI---------------QDLKRSSNCNVIEGVAVAVEP---IVGVGEGTVKRTKQK 863
                   .||:               .||:|..        |...||   ..|..|.....|:.|
Human   535 -------GGVLFAPFGRAGAPGPGGGSDLRRRE--------AARAEPRDARTGWPEEPAPETQFK 584

  Fly   864 LEESTSLKKRCQEESQELLLEAVDAGQRRCPSLYRSASSAHS 905
                   ::.||.|.:|.::|....|: ...:|.:.||.:.|
Human   585 -------RRSCQMEFEEGMVEGRARGE-ELAALGKQASFSGS 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166
		DEK_C	326..379	CDD:462592
		DSP_slingshot	385..523	CDD:350363	49/137 (36%)
DUSP8	NP_004411.2	DSP_MapKP	10..137	CDD:238723
		DSP_DUSP8	150..300	CDD:350493	49/137 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..586		65/383 (17%)