DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssh and si:ch211-203d1.3

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_021328548.1	Gene:	si:ch211-203d1.3 / 101886694	ZFINID:	ZDB-GENE-160113-15	Length:	607	Species:	Danio rerio

Alignment Length:	753	Identity:	261/753 - (34%)
Similarity:	357/753 - (47%)	Gaps:	170/753 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VCSLPDDILIFSLTPRDGESEDDEGNSKGNDRSECFFAGKGTALVLALKDIPPLTQSERRLSTDS 69
            :|:.||:.:     ||.|..:          :.|.|...||..|::..::...|.:     .|.|
Zfish    12 ICTTPDEPI-----PRRGRLQ----------KRESFALVKGAVLLVEEEEREGLQE-----ETVS 56

  Fly    70 TRSSNSTQSNNSDIQ-LHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTSDRR 133
            .|.........||.| .||.:|..||:.|||:|:||:|||.|..|.|||:|.       ||.|.:
Zfish    57 PRLGPRHGGQASDTQRRHLHAMISLLRPEDTVKLAVRLESARPVRVRYLLII-------GTLDNK 114

  Fly   134 RHRIMRHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSG 198

Zfish   115 ----------------------------------------------------------------- 114

  Fly   199 MEESCLLGIDC----NERTTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQ 259
             |||.|||:|.    ::..|||||:||.:||.::|||||||||...|.|.||||||:|.|||.||
Zfish   115 -EESLLLGMDFPSLNSDECTIGLVLPIWSDTQVYLDGDGGFSVTSAEVTRIFKPVSIQTMWSVLQ 178

  Fly   260 TLHKVSKKARENNFYASGPSH--DWLSSYERRIESDQSCLNEWNAMDALESRRPPSPDAIRNKPP 322
            .||...::|...   |..||.  :|...|::.:||||.|||||.||..|||.|   .|.......
Zfish   179 ALHGCCERAVRG---AVIPSSGLEWAQFYKQNVESDQLCLNEWGAMTGLESVR---KDTGGRSSS 237

  Fly   323 EKEETESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQMDAPTK 387
            .:|..|..||.:|:.||.:.||:.:|||.:|..||..:.:|:.:||.:||.||:|.:.|||.|::
Zfish   238 NRESVEREIKAQLRDIMRTEDLENITSKQVRTSLESRIGIDMKDYKEYIDNEMMVTMAQMDKPSR 302

  Fly   388 IFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTF 452
            |.:::||||||||:|.||||||.|.:|||||.|||||||..|.|.|:||||.|.|:||.:|::|:
Zfish   303 ILDYLYLGSEWNAANFEELQKNNVGYILNVTMEIDNFFPECFTYMNIRVYDVEATDLLSHWNNTY 367

  Fly   453 RYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLE 517
            .:|..|:..|..||||||||||||||.|||:.||...|...|||.||::||..::||:.||.||.
Zfish   368 MFINEARKSGQAVLVHCKMGVSRSASTVIAFLMKQQGWTLDQALNHVRERRPIVQPNEGFLKQLN 432

  Fly   518 TYSGMLDAMKNKEKLQRSKSETNLKSTKDARLLPGSEPTPLIQALNQAKSKSTGEAGVTPDGEEE 582
            ||||:|:|.|     ||..:....||..|||       .|.:.     ..::||:.....:.|||
Zfish   433 TYSGILNASK-----QRHSALWRRKSKADAR-------QPSVH-----NEQATGDENEEKEEEEE 480

  Fly   583 DGSRMHRRSIAQKSQRRMVRRSSSTSPKTQTAVV-TKQQSQSMENLTPERSVAEEPKNMRFPGSN 646
            :                      |.||..:::.. |....|..||:.                ..
Zfish   481 E----------------------SQSPDEESSEEDTDVFEQMCENVL----------------DT 507

  Fly   647 GENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQQPVWTSLTKLITQTSHLGKSVSGSSS 711
            ||..|.|.||.|.||:...:|       ....|:.::....:..|: :|..:...:.|.:|....
Zfish   508 GEAESATSNQFLSIQESDKVS-------SSPSRSGRMDLFSLMQSI-QLDDEDRGMDKEMSVCQR 564

  Fly   712 GNIDSRRDSSCSDVFSSQVDSVFAKDEGEKRQRRKTHS 749
            .:...||.|......:.|...|.|..|...||.:.|::
Zfish   565 LSPGQRRRSQGRRGLTYQRAHVDASPEPSSRQTQHTNN 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	98/298 (33%)
		DEK_C	328..379	CDD:285919	22/50 (44%)
		DSPc	385..519	CDD:238073	79/133 (59%)
si:ch211-203d1.3	XP_021328548.1	SSH-N	3..230	CDD:212166	103/316 (33%)
		DEK_C	243..294	CDD:312337	22/50 (44%)
		DSPc	299..434	CDD:238073	79/134 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	1	1.000	-	-		FOG0002581
OrthoInspector	1	1.000	-	-		otm25466
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45864
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	8.000