DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssh and ssh3

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_002938546.1	Gene:	ssh3 / 100488263	XenbaseID:	XB-GENE-5816848	Length:	688	Species:	Xenopus tropicalis

Alignment Length:	836	Identity:	284/836 - (33%)
Similarity:	396/836 - (47%)	Gaps:	199/836 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSMQVCSLPDDILIFSLTPRDGESEDDEGNSKGNDRSECFFAGKGTALVLALKDIPPLTQSERRL 65
            :::||.||...   .::||   ..:|::...|...|.:.|...||.||:|.       .:.|..:
Frog     4 VTLQVSSLDAG---SNITP---VQDDEKSRRKRMQRRQSFVMVKGAALLLQ-------DEGEHAV 55

  Fly    66 STDSTRSSNSTQSNNSDIQLHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTS 130
            :|:...|....:.     |:|||||..||:.|||||:||:||..||...|||::.|
Frog    56 TTEPLPSYGPNEQ-----QIHLQSMLRLLREEDTLKLAVRLEPVRSCLIRYLLVVS--------- 106

  Fly   131 DRRRHRIMRHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKN 195
                             |.|
Frog   107 -----------------STG--------------------------------------------- 109

  Fly   196 TSGMEESCLLGID-------CNERTTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQA 253
            .|..||:.|||:|       |   .|:|.|:||.::|.:.|||||||:|........|||:|||.
Frog   110 KSNEEETVLLGVDFPHDGSLC---CTVGTVLPIWSNTQVFLDGDGGFTVTSGMDICPFKPISVQT 171

  Fly   254 MWSALQTLHKVSKKARENNFYASGPSHDWLSSYERRIESDQSCLNEWNAMDALES-RRPPSPDAI 317
            |||.||.|||..:.|..||..:|...|..|..|:....|.|.|||.|.|...:|| ||.|:
Frog   172 MWSLLQMLHKACESALYNNVISSSSLHSGLIYYQSSRGSPQGCLNAWTASPDIESVRRDPA---- 232

  Fly   318 RNKPPEKEETESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQM 382
               .||:||||.:|::||:.|:...||:.:|||.:|..||:.....|.:||.|||.||::||.||
Frog   233 ---TPEREETERIIRLKLRDILRESDLENITSKEVRSALEQHTLCALQDYKEFIDNEMIIILAQM 294

  Fly   383 DAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKY 447
            |.|::||.::|||||||||||||||||.|.||||||||||||||..|:|.|:||.|:|.|||::|
Frog   295 DRPSEIFPYLYLGSEWNASNLEELQKNKVSHILNVTREIDNFFPELFKYLNIRVLDEENTNLMQY 359

  Fly   448 WDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNF 512
            |.:|..:||..:.:||:||||||||||||||.|||||||.|:|..:.|:.|||:||:.::||..|
Frog   360 WKETHAFITAGRRQGSRVLVHCKMGVSRSASTVIAYAMKEYEWTLETAMRHVKERRNIVQPNAGF 424

  Fly   513 LNQLETYSGMLDAMKNKEKLQRSKSETNLKSTKDARLLPGSEP-------------TPLIQALN- 563
            :.||:||.|:|.|.|.:        .:.|.....|..||...|             ||.:|.:|
Frog   425 IRQLQTYQGILGASKQR--------HSYLWDPSSAPPLPQVFPPPKNFSRHTTSPLTPRLQKMNL 481

  Fly   564 --QAKSKSTGEAGVTPDGEEEDGSRMHRRSIAQKSQRRMVRRSSS-----TSPKTQTAVVTKQQS 621
              ..:|.|..:|..|...|:|..|.:......||..   :..|:|     |.||....|:.|:|
Frog   482 RTLMRSISEMDATDTISEEKESTSELEENIFKQKVN---ILESTSKNLQGTFPKRNEHVLYKEQ- 542

  Fly   622 QSMENLTPERSVAEEPKNMRF-PGSNGENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQ 685
                 :|.|    |:.|.|:. .|...|    .:|..|...|.|.:|:|.:    ||...||
Frog   543 -----ITLE----EDKKLMKLEKGPESE----VKNHTLQEIKETEVSIRLK----EAKEKDQ--- 587

  Fly   686 QPVWTSLTKLITQTSHLGKSVSGSSSGNIDSRRDSSCSDVFSSQVDS---VFAKDEGEKRQRRKT 747
                        :|:....|:         ::::||..:||.|...:   ..|:...:|.:..:.
Frog   588 ------------ETNKESSSI---------TQQNSSLDEVFESSTPTRSPQMARYACQKFKHPEQ 631

  Fly   748 H------------SWTESLGPSGGIVLDPTPQQQKQQSNAILRPRGTRQRELPSRH 791
            |            :..:||.....|.|  ..:|.|:..:...:.|..||:.:...|
Frog   632 HPEDIQNSKVCFVANLQSLSEEEKITL--VSRQLKKDEHGERKARFARQQNVVDTH 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	91/299 (30%)
		DEK_C	328..379	CDD:285919	21/50 (42%)
		DSPc	385..519	CDD:238073	86/133 (65%)
ssh3	XP_002938546.1	SSH-N	3..231	CDD:212166	97/318 (31%)
		DEK_C	238..291	CDD:370106	23/52 (44%)
		PTP_DSP_cys	294..437	CDD:391942	92/142 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10691
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	1	1.000	-	-		FOG0002581
OrthoInspector	1	1.000	-	-		otm49159
Panther	1	1.100	-	-	O	PTHR45864
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020