DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssh and dusp10

DIOPT Version :9

Sequence 1:	NP_733063.1	Gene:	ssh / 42986	FlyBaseID:	FBgn0029157	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_003200822.1	Gene:	dusp10 / 100034609	ZFINID:	ZDB-GENE-041014-271	Length:	459	Species:	Danio rerio

Alignment Length:	518	Identity:	118/518 - (22%)
Similarity:	192/518 - (37%)	Gaps:	144/518 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LVLALKDIPPLTQSERRLSTD-----STRSSNSTQSNNSDIQLHLQSMFYLLQREDTLKMAVKLE 107
            :|:||.  .|:...|.||..|     :|....:..|:.:.:::...::.|:
Zfish    10 IVVALP--RPIRPQELRLRLDTSYLETTVGKTTVISSTTVVKIQAATLSYM-------------- 58

  Fly   108 SQRSNRTRYLV--IASRSCCRSGTSDRRRHRIMRHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQT 170
            ...|..||.|.  .:|.|||...|.::                .|..|::||.:.:.....|:|.
Zfish    59 PSSSGSTRSLTCGCSSASCCTVTTYEK----------------DGQVSASSPNLHSGSGYGVQQG 107

  Fly   171 ATEASSKCDKTADKENATAAGDNKNTSGME-----------ESCLLGIDCNERTTIGLVVPILAD 224
            :...|           |.:...:....||.           ..|.||      ..|| .||::.|
Zfish   108 SVHGS-----------APSLTSSLTRGGMRVIHPNELAKKLTHCPLG------HPIG-PVPVIID 154

  Fly   225 TTIHLDGDGGFSVKVYEKTHIFKPVSV---------QAMWSALQTLHKVSKKARENNFYASGPSH 280
            ....|:         :.|:||...:.:         :.....:..|..:|.:..:::|
Zfish   155 CRPFLE---------FNKSHIRGAMHINCSDKISRRRLQQGKITVLDLISCRQSKDSF------- 203

  Fly   281 DWLSSYERRIESDQSCLNEWNAMD------------ALESRRPPSPDAIRNKPPEKEETESVIKM 333
                   :.|.|.:..:.:.:.:|            .|||.|....|.|            |:|.
Zfish   204 -------KGIFSKELVVYDESTVDPGRLTPSQPLHVVLESLRREGKDPI------------VLKG 249

  Fly   334 KLKAIMMS-VDLDEVTSKYIRGR-------LEEILDMDLGEYKSFIDAEMLVILGQMDAPTKIFE 390
            .|.....: .||.|.:.....|:       |...|...|.......:||:          |.:..
Zfish   250 GLSGFRQTHADLCEHSLHLDEGQDGSGAMGLSGALPHSLPSTPDIENAEL----------TAVLP 304

  Fly   391 HVYLGSEWNASNLEELQKNGVRHILNVTREID--NFFPGTFEYFNVRVYDDEKTNLLKYWDDTFR 453
            .:|||:|.:|.:||.||:..:..:||||..:.  ::....|.|..:...|..|.||.:|:::.|.
Zfish   305 FLYLGNERDAQDLELLQRLDIGFVLNVTTHLPLYHYDIARFCYKRLPATDSNKQNLRQYFEEAFE 369

  Fly   454 YITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQL 516
            :|..|...|..:|:||:.||||||::||||.||........|.:.||.||..|.||.||:.||
Zfish   370 FIEEAHQAGRGLLIHCQAGVSRSATIVIAYLMKHTWMTMTDAYKFVKSRRPIISPNLNFMGQL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssh	NP_733063.1	SSH-N	21..313	CDD:212166	52/303 (17%)
		DEK_C	328..379	CDD:285919	12/58 (21%)
		DSPc	385..519	CDD:238073	52/134 (39%)
dusp10	XP_003200822.1	DSP_MapKP	127..262	CDD:238723	28/176 (16%)
dusp10	XP_003200822.1	DSPc	298..436	CDD:238073	53/145 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820