DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and Osbpl6

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_663500.2	Gene:	Osbpl6 / 99031	MGIID:	2139014	Length:	967	Species:	Mus musculus

Alignment Length:	969	Identity:	250/969 - (25%)
Similarity:	390/969 - (40%)	Gaps:	309/969 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVIS- 78
            :|::|   ||.  :||:.:|:|||..|:|.|.:...:|.   :|.:  ||    ::|....|:|
Mouse    90 EGFMLKKRKWP--LKGWHKRFFVLDNGMLKYSKAPLDIQ---KGKV--HG----SIDVGLSVMSI 143

  Fly    79 ---------NGGTQTFHIKAGTEVERQSWVTAL-----------------------------ELA 105
                     :.....:|:|..::....:||:.|                             |.:
Mouse   144 KKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPATSTAESS 208

  Fly   106 KAKAIRAIE-----------------------CEEEEETETAHVVPSQEISSVVRDLT------- 140
            .|..:..::                       |...:....|.:..|:|:.....||.
Mouse   209 PAANVSVVDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLV 273

  Fly   141 ------DRLESMR-------------TCYDLITK----------------------HGAALQRAL 164
                  ..||.::             .|.|:..|                      .|...:...
Mouse   274 ELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKGQF 338

  Fly   165 N------------------------------------DLE--------TNEEESLGSRTK----- 180
            |                                    |:|        |:..||....||
Mouse   339 NTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEF 403

  Fly   181 -----------------IVNERATLFRITSNAMINAGN--------DYLHTAEAQGHKWSKMLHH 220
                             |..|:..|.::.|....|.|:        ..|..:|..|..|:  |:.
Mouse   404 CLIAQKVHSLLKSAFNSIAIEKEKLKQVVSEQDHNKGHSTQMARLRQSLSQSEGAGKSWA--LNQ 466

  Fly   221 EREQRQRLEEI------------IEQMAKQQSQMEQAAVLVRQNKPVSSTSGAGTAGSLVTSDEE 273
            ..|.|.||..|            :..:.......||..|.:..::.|::.|      .|..|:..
Mouse   467 NAELRSRLNRIHSESTICDHVVSVNIIPSPDEPGEQIHVSLPLSQQVANES------RLSMSESV 525

  Fly   274 MEFFDAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQ 338
            .|||||:|...|.|....|:||.|  ::|       |...|.:.   |.::|.:|...|.:...:
Mouse   526 SEFFDAQEVLLSASSSENEASDDE--SYI-------SDVSDNIS---EDNTSVADNISRQILNGE 578

  Fly   339 QVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGI 403
                ::.....:|.:        ..|||.                      .||..|  |:||.|
Mouse   579 ----LTGGAFRNGRR--------TCLPAP----------------------CPDTSN--INLWNI 607

  Fly   404 MKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATT 468
            ::|.|||||||:.||:..||||:.||.|.|:.||:|:||.|:...|..|::..:|||.||.|.:|
Mouse   608 LRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCST 672

  Fly   469 TNRTG-KPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGK 532
            ..|.| |||||:|||||||.| :|.|:|..:||||||||::|.||||||:..||:....:||.||
Mouse   673 YFRAGSKPFNPVLGETYECIR-EDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGK 736

  Fly   533 YVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCI--LNF 595
            .::|.|:|.:.|..|..|..|.|.||||.::||:.|:.|::.:||:.:|.::::   .||  |.|
Mouse   737 SMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTLRNTKSS---VCICKLTF 798

  Fly   596 IPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTW--DMKIEIAPVLKTSGSVSSPTYTTGEFKLAW 658
            :..:|::.:| ..|:|||::::.:|...:.|.|  .:...:||                ..|..|
Mouse   799 VKVNYWNSNV-NEVQGVVIDQEGKVVHRLFGKWHEGLYCGVAP----------------SAKCIW 846

  Fly   659 RRRPAPPDSDKFYNFTTLACQLNEEE----EGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEK 719
            |....|.:.:.:|.||..|.:|||.:    :.:.|||:|.|||||.:|:|:.:.:..||.|:||.
Mouse   847 RPGSLPTNYELYYGFTRFAVELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAAAEKQRVEEL 911

  Fly   720 QRTERR-RRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNF 777
            ||:.|| ..||..|           :.|.:||:..:....| ..|..:||||.:....|
Mouse   912 QRSRRRYMEENNLE-----------HIPKFFKKVIDANQRE-AWVSNDTYWELRKDPGF 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	26/130 (20%)
		PH_OSBP_ORP4	17..113	CDD:270101	27/136 (20%)
		Oxysterol_BP	399..764	CDD:279564	147/374 (39%)
Osbpl6	NP_663500.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		PH_ORP3_ORP6_ORP7	66..188	CDD:270104	25/108 (23%)
		Oxysterol_BP	603..951	CDD:395990	150/380 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810