DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and OSH3

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_011940.1	Gene:	OSH3 / 856472	SGDID:	S000001115	Length:	996	Species:	Saccharomyces cerevisiae

Alignment Length:	850	Identity:	221/850 - (26%)
Similarity:	364/850 - (42%)	Gaps:	159/850 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 MKGWLL-KWTNYIKGYQRRWFVLS--KGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVIS 78
            ::|:|| |....::|:::|:|.|.  .|.||||.|  :.|.||||.|.:..:.:........:|.
Yeast   224 LQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLN--DHNQTCRGEIVISLSSVSANKKDKIIII 286

  Fly    79 NGGTQTFHIKAGTEVERQSWVTALELA-----KAKAIRAIE-----CEEEEET-------ETAHV 126
            :.|.:.:.:||.|:...||||.||:..     :.|....:|     .::::|.       :..|:
Yeast   287 DSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHL 351

  Fly   127 VPSQEISSVVRDLTDRLESMRTCYDLITKHGAA-----LQRALNDLETNEEESL----------- 175
            .|:....|.:.......:.|...|..:.....|     |:.....||..:::||
Yeast   352 TPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRS 416

  Fly   176 -------GSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIE 233
                   .|.:...|.|.:.|..:|:.|  ..:|.|.:.|...:| :.:.|....|...||..:.
Yeast   417 EGLNGTHSSSSVFTNNRVSSFNHSSSGM--TSSDSLASEEVPSNK-TYIEHALYNQLADLEVFVS 478

  Fly   234 QMAKQ-QSQMEQAAVLVRQNKP--VSSTSGAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSD 295
            :...| :...:...:|.::.|.  ||.||         ...|..|||||||             :
Yeast   479 RFVTQGEVLFKDHQILCKKAKDTRVSLTS---------YLSENDEFFDAEE-------------E 521

  Fly   296 CERGTFILKMHKRRSSSEDQVEGHLEGSS--SESDEQKRTVQTVQQVCLVSAPRVASGG----QG 354
            ..||..||      ..:||.:...:|.:.  .:||:.:.|    ::|.|..:.::||..    ..
Yeast   522 ISRGVIIL------PDTEDDINNIVEETPLLGKSDQNEFT----KEVQLSGSEQIASSSVESYTT 576

  Fly   355 DDDDDVDKAL------------------PAKESTDSIYGRNW----NPDLIKKRRDRVPDKPNHP 397
            :|::...|.|                  .|:.||::...::.    .|..:.:|.| :|:....|
Yeast   577 NDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRND-IPEAAASP 640

  Fly   398 ISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTV 462
            .||...::..:|||||.|.||:..|||:|:||.:.|.:||..:|..|....|   .:.:::||.:
Yeast   641 PSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPD---PITFVSAFAI 702

  Fly   463 ---SAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFS 524
               |.|...|....|||||||.||:|..| :|.|:|.::|:|||.|||.|...|..:|.|....:
Yeast   703 SFLSIYRDKTRTLRKPFNPLLAETFELIR-EDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVT 766

  Fly   525 MTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGH 589
            .:.||.||.:::|..|.:.::|..:|..:.|.:.||.:.|:|.|:.:::...|.|:..|:..:.|
Yeast   767 PSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSH 831

  Fly   590 KCILNFIPYSYFS-RDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGE 653
               :.|.....|| |.....|..:.....|..|..:.|.|           |....:..|:.|
Yeast   832 ---ILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKW-----------TQSLANETTHET-- 880

  Fly   654 FKLAWRRRPAPPDSDKFYNFTTLACQLNE----EEEGVAPTDSRLRPDQRLMEQGDWDESNKEKL 714
               .|.......:..|.|.||.....|||    |:..:.|||||||||.|..|:|:.|::.:.||
Yeast   881 ---IWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKL 942

  Fly   715 RLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEG 779
            :||:.|| |||.:..:.             ||.:|  ||...:|........:|||.:...::..
Yeast   943 KLEQLQR-ERRNKGQDV-------------EPKYF--EKVSKNEWKYITGPKSYWERRKKHDWSD 991

  Fly   780 CPDIY 784
            ...::
Yeast   992 ISQLW 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	31/97 (32%)
		PH_OSBP_ORP4	17..113	CDD:270101	32/103 (31%)
		Oxysterol_BP	399..764	CDD:279564	119/372 (32%)
OSH3	NP_011940.1	PH_Osh3p_yeast	223..313	CDD:241443	31/90 (34%)
OSH3	NP_011940.1	Oxysterol_BP	642..982	CDD:395990	120/378 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
TreeFam	0	0.000	Not matched by this tool.
	5	4.940