Protein Alignment Osbp and OSH3

DIOPT Version :10

• Sequence 1: NP_477271.1
• Gene: Osbp / 42985
• FlyBaseID: FBgn0020626
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_011940.1
• Gene: OSH3 / 856472
• SGDID: S000001115
• Length: 996
• Species: Saccharomyces cerevisiae
• Alignment Length: 850
• Identity: 221/850 - (26%)
• Similarity: 364/850 - (42%)
• Gaps: 159/850 - (18%)

  Fly    17 MKGWLL-KWTNYIKGYQRRWFVLS--KGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVIS 78
            ::|:|| |....::|:::|:|.|.  .|.||||.|  :.|.||||.|.:..:.:........:|.
Yeast   224 LQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLN--DHNQTCRGEIVISLSSVSANKKDKIIII 286

  Fly    79 NGGTQTFHIKAGTEVERQSWVTALELA-----KAKAIRAIE-----CEEEEET-------ETAHV 126
            :.|.:.:.:||.|:...||||.||:..     :.|....:|     .::::|.       :..|:
Yeast   287 DSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHL 351

  Fly   127 VPSQEISSVVRDLTDRLESMRTCYDLITKHGAA-----LQRALNDLETNEEESL----------- 175
            .|:....|.:.......:.|...|..:.....|     |:.....||..:::||
Yeast   352 TPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRS 416

  Fly   176 -------GSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIE 233
                   .|.:...|.|.:.|..:|:.|  ..:|.|.:.|...:| :.:.|....|...||..:.
Yeast   417 EGLNGTHSSSSVFTNNRVSSFNHSSSGM--TSSDSLASEEVPSNK-TYIEHALYNQLADLEVFVS 478

  Fly   234 QMAKQ-QSQMEQAAVLVRQNKP--VSSTSGAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSD 295
            :...| :...:...:|.::.|.  ||.||         ...|..|||||||             :
Yeast   479 RFVTQGEVLFKDHQILCKKAKDTRVSLTS---------YLSENDEFFDAEE-------------E 521

  Fly   296 CERGTFILKMHKRRSSSEDQVEGHLEGSS--SESDEQKRTVQTVQQVCLVSAPRVASGG----QG 354
            ..||..||      ..:||.:...:|.:.  .:||:.:.|    ::|.|..:.::||..    ..
Yeast   522 ISRGVIIL------PDTEDDINNIVEETPLLGKSDQNEFT----KEVQLSGSEQIASSSVESYTT 576

  Fly   355 DDDDDVDKAL------------------PAKESTDSIYGRNW----NPDLIKKRRDRVPDKPNHP 397
            :|::...|.|                  .|:.||::...::.    .|..:.:|.| :|:....|
Yeast   577 NDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRND-IPEAAASP 640

  Fly   398 ISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTV 462
            .||...::..:|||||.|.||:..|||:|:||.:.|.:||..:|..|....|   .:.:::||.:
Yeast   641 PSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPD---PITFVSAFAI 702

  Fly   463 ---SAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFS 524
               |.|...|....|||||||.||:|..| :|.|:|.::|:|||.|||.|...|..:|.|....:
Yeast   703 SFLSIYRDKTRTLRKPFNPLLAETFELIR-EDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVT 766

  Fly   525 MTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGH 589
            .:.||.||.:::|..|.:.::|..:|..:.|.:.||.:.|:|.|:.:::...|.|:..|:..:.|
Yeast   767 PSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSH 831

  Fly   590 KCILNFIPYSYFS-RDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGE 653
               :.|.....|| |.....|..:.....|..|..:.|.|           |....:..|:.|
Yeast   832 ---ILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKW-----------TQSLANETTHET-- 880

  Fly   654 FKLAWRRRPAPPDSDKFYNFTTLACQLNE----EEEGVAPTDSRLRPDQRLMEQGDWDESNKEKL 714
               .|.......:..|.|.||.....|||    |:..:.|||||||||.|..|:|:.|::.:.||
Yeast   881 ---IWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKL 942

  Fly   715 RLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEG 779
            :||:.|| |||.:..:.             ||.:|  ||...:|........:|||.:...::..
Yeast   943 KLEQLQR-ERRNKGQDV-------------EPKYF--EKVSKNEWKYITGPKSYWERRKKHDWSD 991

  Fly   780 CPDIY 784
            ...::
Yeast   992 ISQLW 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH_OSBP_ORP4	17..113	CDD:270101	32/103 (31%)
		Oxysterol_BP	399..773	CDD:460126	122/381 (32%)
OSH3	NP_011940.1	PH_Osh3p_yeast	223..313	CDD:241443	31/90 (34%)
		Oxysterol_BP	642..985	CDD:460126	122/381 (32%)