DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Osbp and OSH2

DIOPT Version :9

Sequence 1:NP_477271.1 Gene:Osbp / 42985 FlyBaseID:FBgn0020626 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_010265.1 Gene:OSH2 / 851543 SGDID:S000002177 Length:1283 Species:Saccharomyces cerevisiae


Alignment Length:1035 Identity:278/1035 - (26%)
Similarity:426/1035 - (41%) Gaps:306/1035 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PEMKGWLLKWTNYIKGYQRRWFVLS-KGVLSYYRNQSEINHTCRGTISLHGALIHTVDS---CTF 75
            |..||:|.||||:..||:.|||:|| .|.||||::||.::.. |||:.:....:| :||   ..|
Yeast   290 PTYKGFLKKWTNFAHGYKLRWFILSGDGNLSYYKDQSHVDRP-RGTLKVSTCRLH-IDSSEKLNF 352

  Fly    76 VISNG--GTQTFHIKAGTEVERQSWVTALE-----------LAKAKAI--------RAIECEEEE 119
            .:..|  ||..:.:|....:|...||.|::           |.|.||:        ::.......
Yeast   353 ELLGGITGTTRWRLKGNHPIETTRWVNAIQSAIRFAKDKEILNKKKAVPPSLALKNKSPALISHS 417

  Fly   120 ETE------------TAH--VV----------PSQEISSVVRD------------------LTDR 142
            :|:            |.|  |:          ||..:|.|..:                  :.:|
Yeast   418 KTQGSLPEASQYYQHTLHKEVIQPSSVSLYRRPSNNLSVVSSEIQLNDNLTESGKRFVSKMIENR 482

  Fly   143 LESMRTCYDLITKHGAALQ--RALNDLETNEEESLGSRT-----KIVNERATLFR---ITSNAMI 197
            |:..:|...:.|  |:|||  |:.|.|::|.....||..     |:.| .|.|.:   .|.:...
Yeast   483 LDGSKTPVGVHT--GSALQRVRSSNTLKSNRSMQSGSGVASPIDKVPN-GANLSQSNTTTGSTAS 544

  Fly   198 NAGNDYLHT-----AEAQGHKWSKMLHHEREQ----------RQRLE--------------EIIE 233
            .:.|:|:..     |.:...:....::.:|::          :::|:              |:||
Yeast   545 LSDNNYIDNFEGDEANSDDEEEDLGINFDRDEEYIKAQYGPYKEKLDMYEQAISIELSSLIELIE 609

  Fly   234 Q--------MAKQQSQMEQAAVL--------VRQNKPVSSTSGAGTAGSL-VTSDEEMEF----- 276
            |        :..::|.:..:.:.        .|..:.|...|..|...:: |.|.:|:|.     
Yeast   610 QEEPSPEVWLTIKKSLINTSTIFGKLKDLTYKRDKRLVDMVSKQGDVNNVWVQSVKELEMELSNK 674

  Fly   277 ------FD--------------AEEHGYSGSGRSPES-----SDCERGT------FILKMHKRRS 310
                  .|              .|.|..:|:..|.|:     ||....|      ||....:...
Yeast   675 TERLASIDKERRGLKKILHKKLLESHATAGNKESLENDKEQESDTTASTLGQIAKFISATKEEDE 739

  Fly   311 SSE-----------DQV----EGHLEGSSS----------------------------ESDEQKR 332
            :|:           |:|    |.|.|.|::                            ||:.:|.
Yeast   740 ASDADEFYDAAELVDEVTELTEAHPEISTAAAPKHAPPPVPNETDNDSQYVQDEKSKIESNVEKT 804

  Fly   333 TVQTVQQVCLVSAPRVASGGQGDDDDDVDKAL--------------PAKESTDSIYGRN------ 377
            :.:..:|..||:          :|:...|::|              ..||...|:.|..      
Yeast   805 SQKFEKQNNLVT----------EDEPKTDQSLKNFKAEDKESQVKEKTKEIASSVIGEKTIVAVT 859

  Fly   378 -----------------WNPDLIKKRRDRVPDKPNHP-ISLWGIMKNCIGKDLSKIPMPINFNEP 424
                             ...|.|:||...  ||.:.| ||||.::|:.:|||::::.:|:.||||
Yeast   860 TVQKRKEEYLLKEGSYLGYEDGIRKRLSM--DKDDRPKISLWAVLKSMVGKDMTRMTLPVTFNEP 922

  Fly   425 LSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRM 489
            .|:|||:.||.||:|:||.|||.:|...:..|:||||.|:||:||.|..||||||||||:|..|.
Yeast   923 TSLLQRVAEDLEYSELLDQAATFEDSTLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRP 987

  Fly   490 DDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQF-PNSGRR- 552
            |.. :|...||||||||::|...||..|..|.|..:.:||.|:...:..||..:::. ||...: 
Yeast   988 DKQ-YRFFTEQVSHHPPISATWTESPRWDFWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKE 1051

  Fly   553 --YSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRS-----VK 610
              |:|:|...||..|::|...||.|||:.:  .....|..|.|      ||.....||     :.
Yeast  1052 ELYTWKKPNNTVIGILIGNPQVDNHGEVNV--VNHTTGDHCKL------YFKARGWRSSGAYEIT 1108

  Fly   611 GVVMNKDNEVKWVVRGTWDMKIEIAPVLK----------TSGSVSSPTYTTGEFKLAWRR--RPA 663
            |.|.||..:..|::.|.|:..|....|:|          |:.|..:.....|...|.|:.  ||.
Yeast  1109 GEVYNKKKQKVWILGGHWNEAIFAKKVVKDGDLSLEKTRTAASAGNGPTDDGTKFLIWKANDRPE 1173

  Fly   664 PPDSDKFYNFTTLACQLNEEE----EGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTER 724
            .|     :|.|..|..||..:    ..:.|||:|||||||.||.|.:||:..||.|:|||||..|
Yeast  1174 EP-----FNLTPFAITLNAPQPHLLPWLPPTDTRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAAR 1233

  Fly   725 RRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            |:||....|          |.|.||.|:....::.....:...||..:...:.:.|.||:
Yeast  1234 RKREENNLE----------YHPQWFVRDTHPITKAKYWRYTGKYWVKRRDHDLKDCGDIF 1283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OsbpNP_477271.1 PH 15..107 CDD:278594 38/108 (35%)
PH_OSBP_ORP4 17..113 CDD:270101 40/120 (33%)
Oxysterol_BP 399..764 CDD:279564 148/389 (38%)
OSH2NP_010265.1 ANKYR <47..194 CDD:223738
ANK repeat 60..104 CDD:293786
ANK repeat 106..137 CDD:293786
Ank_5 191..247 CDD:404699
PH_Osh1p_Osh2p_yeast 289..391 CDD:241446 37/102 (36%)
Oxysterol_BP 897..1268 CDD:395990 148/394 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344775
Domainoid 1 1.000 255 1.000 Domainoid score I325
eggNOG 1 0.900 - - E1_KOG1737
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 330 1.000 Inparanoid score I427
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46720
orthoMCL 1 0.900 - - OOG6_101373
Panther 1 1.100 - - O PTHR10972
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3013
SonicParanoid 1 1.000 - - X203
TreeFam 1 0.960 - -
1211.780

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