DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and ORP3C

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_200750.1	Gene:	ORP3C / 836061	AraportID:	AT5G59420	Length:	457	Species:	Arabidopsis thaliana

Alignment Length:	487	Identity:	141/487 - (28%)
Similarity:	222/487 - (45%)	Gaps:	102/487 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 DEEMEFFDAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQ 335
            :|...||.|...|:|..|.:.                  |.|.:.|:|: ||           |:
plant     7 NENKGFFAAMTSGFSMFGTAV------------------SRSVNGVQGN-EG-----------VE 41

  Fly   336 TVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISL 400
            .:.          ..||:.|.:::..|            || |..:    .||          |.
plant    42 VIN----------PEGGKEDAEEEAQK------------GR-WKDE----ERD----------SY 69

  Fly   401 WGIMKNCIGKDL-SKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSA 464
            |.:|:..||.|: |.:.:|:...||::|||::.|..||:.:||.|..|:|...:|.|.:::.:|.
plant    70 WKMMQKYIGSDITSMVTLPVVIFEPMTMLQKMAEIMEYSHLLDQADECEDPYLRLVYASSWAISV 134

  Fly   465 YATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKF 529
            | ....||.|||||:||||||  .::..|...::||||||||::|.|.|::::.    :.:|||.
plant   135 Y-YAFQRTWKPFNPILGETYE--MVNHGGISFISEQVSHHPPMSAGHAENEHFI----YDITSKL 192

  Fly   530 R----GKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHK 590
            :    |..|.:.|:|...|.....|.........|.::|:|.|:.|||..|||.:  :....|.|
plant   193 KTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKIHNLIFGRTWVDSPGEMVM--TNLTTGDK 255

  Fly   591 CILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEFK 655
            .:|.|.|..:|... :..|.|.|.:...|.|.::.|.|:.|:...|    ..:...|...| |.|
plant   256 VVLYFQPCGWFGSG-RYEVDGYVYSAAEEPKIMMTGKWNEKMSYQP----CDAEGEPLPGT-ELK 314

  Fly   656 LAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVA---PTDSRLRPDQRLMEQGDWDESNKEKLRLE 717
            ..|.....|.:.:  :.:|..|.::|..:...|   .:|||:|||:..:||||..::..||..||
plant   315 EVWHLADVPKNDN--FQYTHFAHKINSFDTAPAKLLASDSRIRPDRYSLEQGDLSKAGSEKHSLE 377

  Fly   718 EKQRTERRRRENEAEEAAAEGRPYPAYEPMWF 749
            |:||.|:|.||.:.::          :.|.||
plant   378 ERQRAEKRTRETKGQK----------FTPRWF 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594
		PH_OSBP_ORP4	17..113	CDD:270101
		Oxysterol_BP	399..764	CDD:279564	118/359 (33%)
ORP3C	NP_200750.1	Oxysterol_BP	68..418	CDD:279564	118/359 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810