DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and ORP2A

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001328217.1	Gene:	ORP2A / 828349	AraportID:	AT4G22540	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	816	Identity:	238/816 - (29%)
Similarity:	360/816 - (44%)	Gaps:	210/816 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GWLLKWTNYIKGYQRRWFVLSKGVLSY--YRNQSEINHTCR-------GTISLHGALIHTVDSCT 74
            |.|.||||:.||::.|||:|..|:|||  .|....:|....       |.||  |..:..:|||:
plant    55 GILYKWTNFGKGWRSRWFLLRNGILSYSKIRRPENLNLLSPDDDVRLIGDIS--GERLSRMDSCS 117

  Fly    75 ----------------------------FVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIR 111
                                        |.|.. .|:|.|::..:..:|.:|:.|  ||..|.|.
plant   118 GRRKQQKTVGIVHLKVSSFRESKSDDRKFYIFT-ATKTLHLRTDSITDRAAWLQA--LASTKCIF 179

  Fly   112 AIECEEEEETETAHVVPSQEISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLETNEEESLG 176
            .:.....:.:    .:|.:::|.....|..||                          :||   |
plant   180 PLRSLNGDFS----FIPPKDLSISTERLKKRL--------------------------HEE---G 211

  Fly   177 SRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQ 241
            ....:|.|...:.....:.|               |...|:||   |:|..|.:.:.|:  :.:.
plant   212 MNENLVKECEQIMLSEFSEM---------------HGQVKLLH---EERTNLLDALRQL--EAAN 256

  Fly   242 MEQAAVLVRQNKPVSSTSGAG---TAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFIL 303
            :|..|    ..|...|:.|.|   ...:..:||.:.||.|..|
plant   257 LEVGA----SGKHEFSSLGRGKYSECSTTASSDGKQEFEDVSE---------------------- 295

  Fly   304 KMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKE 368
                     ||:...|        |.::          ..:.|.:.|                 |
plant   296 ---------EDEPSFH--------DTKE----------FFNEPNIGS-----------------E 316

  Fly   369 STDSIYGRNWNPDLIKKRRDRVPD--KPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRL 431
            |..:|.|   :.|:  |||.::||  :....:|||.::|:.:||||:::.:|:.||||:|.||:.
plant   317 SNLAISG---HTDI--KRRTKLPDPAEKEKGVSLWSMIKDNVGKDLTRVCLPVYFNEPISSLQKC 376

  Fly   432 VEDYEYTEILDYA---ATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYG 493
            .||.||:.:||.|   ....:...:...:|||.||.||:|..|..||||||||||||.| ..:.|
plant   377 FEDLEYSYLLDRAYEHGKSGNGLLRALNVAAFAVSGYASTEGRHCKPFNPLLGETYEAD-FPEKG 440

  Fly   494 WRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKV 558
            .|..:|:|||||.|.|.|||.|.|..|.:.::.|||.|:.:|:.|:|.:.::| :.|..:.|.||
plant   441 IRFFSEKVSHHPTVIACHCEGKGWKFWGDTNLRSKFWGRSIQVEPVGVLTLEF-DDGEVFQWSKV 504

  Fly   559 TTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWV 623
            |:|:.|||:|||:.|.||.|:|||::.   :.|.|.|...|...|: ...|.|.|.:...:....
plant   505 TSTIYNIILGKLYCDHHGVMQIRGNRQ---YSCTLKFKEQSILERN-PHQVNGFVEDVAGQKAAT 565

  Fly   624 VRGTWDMKI-EIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEG- 686
            :.|.||..: .:|........||.|   .....|.|:|...||:..: ||.|:.|..|||...|
plant   566 IFGKWDDSLYYVAGDGINKSKVSDP---ASNASLLWKRTKPPPNVTR-YNLTSFAITLNELTPGL 626

  Fly   687 ---VAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMW 748
               :.|||||||||||.:|.|:::::|.||.|||.:||..|:.:|:             .:.|.|
plant   627 QEILPPTDSRLRPDQRHLENGEYEKANLEKQRLERRQRMSRQLQES-------------GWRPRW 678

  Fly   749 FKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            |:|:.|..:.:|.    ..||||:..:|::.||||:
plant   679 FERQGESDTFKYT----GGYWEARGHRNWDDCPDIF 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	35/124 (28%)
		PH_OSBP_ORP4	17..113	CDD:270101	37/130 (28%)
		Oxysterol_BP	399..764	CDD:279564	145/372 (39%)
ORP2A	NP_001328217.1	PH_ORP_plant	53..185	CDD:241448	37/134 (28%)
ORP2A	NP_001328217.1	Oxysterol_BP	344..696	CDD:395990	146/378 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	260	1.000	Domainoid score	I482
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I717
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2601
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930