DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and ORP1C

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001319881.1	Gene:	ORP1C / 826368	AraportID:	AT4G08180	Length:	814	Species:	Arabidopsis thaliana

Alignment Length:	844	Identity:	256/844 - (30%)
Similarity:	372/844 - (44%)	Gaps:	198/844 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDAAGNALAEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYY---------------RNQS 50
            :.|..||.:|        |.|.||.||.:|::.|||||..||||||               :...
plant    98 INDIVGNGIA--------GILYKWVNYGRGWRPRWFVLQDGVLSYYKIHGPDKIFVSPETEKGSK 154

  Fly    51 EINHTCRGTISLHGALIHTVDSC-------------------------TFVISNGGTQTFHIKAG 90
            .|.......||.|.....:..||                         .|.|.. ||:..|::|.
plant   155 VIGDESARMISRHNRRGGSSSSCQLRRKPFGEVHLKVSSVRESRSDDKRFSIFT-GTKRLHLRAE 218

  Fly    91 TEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEISSVVRDLTDRLESMRTCYDLITK 155
            |..:|.:||.||:..|....|               :.:.|:.:...:|....|.:|.   .:.:
plant   219 TREDRTTWVEALQAVKDMFPR---------------MSNSELMAPTNNLAMSTEKIRL---RLIE 265

  Fly   156 HGAALQRALNDLE---TNEEESLGSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKM 217
            .|.: :.|:.|.|   .:|..:|.|:..::.::..|
plant   266 EGVS-ELAIQDCEQIMKSEFSALQSQLVLLKQKQWL----------------------------- 300

  Fly   218 LHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPVSSTSG-----AGTAGSLVTSDEEMEFF 277
                      |.:.:.|:..::..:|...|...|.:..:..||     ..:.|:...||::.|..
plant   301 ----------LIDTLRQLETEKVDLENTVVDESQRQADNGCSGELRHEKFSEGTATESDDDNERG 355

  Fly   278 DAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCL 342
            ||.|          |..|.|..||........|||..........||..|||
plant   356 DAAE----------EEFDEEENTFFDTRDFLSSSSFKSSGSGFRTSSFSSDE------------- 397

  Fly   343 VSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPD--KPNHPISLWGIMK 405
                   .|.:.:||.|     |:.:|....|.|       .|||..:||  :....:|||.::|
plant   398 -------DGFESEDDID-----PSIKSIGCNYPR-------VKRRKNLPDPVEKEKSVSLWSMIK 443

  Fly   406 NCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYA---ATCQDECEQLAYIAAFTVSAYAT 467
            :.|||||:|:.:|:.||||||.||:..||.||:.:||.|   ....:...::..:|||.||.||:
plant   444 DNIGKDLTKVCLPVYFNEPLSSLQKCFEDLEYSYLLDRAFEYGKRGNSLMRILNVAAFAVSGYAS 508

  Fly   468 TTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGK 532
            |..|..||||||||||||.| ..|.|.|..:|:|||||.|.|.||:...|..|.:.::.|||.|:
plant   509 TEGRICKPFNPLLGETYEAD-YPDKGLRFFSEKVSHHPMVVACHCDGTGWKFWGDSNLRSKFWGR 572

  Fly   533 YVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIP 597
            .:|::|:|.:.:|| :.|....|.||||::.|:|:|||:.|.:|.|.|.||  || :.|.|.|..
plant   573 SIQLDPVGVLTLQF-DDGEILQWSKVTTSIYNLILGKLYCDHYGTMRIEGS--AE-YSCKLKFKE 633

  Fly   598 YSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEF---KLAWR 659
            .|...|: ...|.|:|.||..:....:.|.||..|..     .:|..|.....:.:.   :|.|:
plant   634 QSIIDRN-PHQVHGIVQNKSGKTVATMFGKWDESIHF-----VTGDCSGKGKLSEDMSGAQLLWK 692

  Fly   660 RRPAPPDSDKFYNFTTLACQLNE----EEEGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQ 720
            |...|.::.| ||.|..|..|||    .:|.:.|||||||||||.:|.|:::.:|.||||||::|
plant   693 RSKPPGNATK-YNLTRFAITLNELTPGLKERLPPTDSRLRPDQRYLENGEFEMANTEKLRLEQRQ 756

  Fly   721 RTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            |..|:.:|.             .::|.||.:||  |||.|  .:|..||||:...::..||||:
plant   757 RQARKMQER-------------GWKPRWFMKEK--GSESY--RYKGGYWEAREDGSWVDCPDIF 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	36/131 (27%)
		PH_OSBP_ORP4	17..113	CDD:270101	38/135 (28%)
		Oxysterol_BP	399..764	CDD:279564	153/374 (41%)
ORP1C	NP_001319881.1	PH_ORP_plant	106..242	CDD:241448	39/159 (25%)
ORP1C	NP_001319881.1	Oxysterol_BP	437..789	CDD:395990	155/380 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	260	1.000	Domainoid score	I482
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75303
Inparanoid	1	1.050	317	1.000	Inparanoid score	I717
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2601
orthoMCL	1	0.900	-	-		OOG6_101373
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830