DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Osbp and ORP3B

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_187541.1	Gene:	ORP3B / 820086	AraportID:	AT3G09300	Length:	458	Species:	Arabidopsis thaliana

Alignment Length:	431	Identity:	142/431 - (32%)
Similarity:	214/431 - (49%)	Gaps:	57/431 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 QGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDL-SKIP 416
            :|..||       |:|  ::..|| |      |:.||        ...|.:|:..||.|: |.:.
plant    51 EGSTDD-------AEE--EASRGR-W------KQEDR--------DGYWKMMQKYIGSDVTSMVT 91

  Fly   417 MPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLG 481
            :|:...||::|||::.|..||:.:||.|...:|...::.|.:::.:|.| ....||.|||||:||
plant    92 LPVIIFEPMTMLQKMAELMEYSHLLDMADKTEDPYLRMVYASSWAISVY-YAFQRTWKPFNPILG 155

  Fly   482 ETYECDRMDDY-GWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQ 545
            ||||   |.:| |...::||||||||::|.|.|::::|......:.:||.|..:.:.|:|...|.
plant   156 ETYE---MANYNGVNFISEQVSHHPPMSAGHAENEHFTYDCTSKLKTKFLGNSIDVYPVGRTRVT 217

  Fly   546 FPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVK 610
            ....|.........|.|:|:|.|:.|||..||| |..:|.. |.|.:|.|.|..:|... :..|.
plant   218 LKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEM-IMTNQTT-GDKVVLYFQPCGWFGSG-RYEVD 279

  Fly   611 GVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTT 675
            |.|.|...|.|.::.|.|:..:...|    ......|...| |.|..|:....|.| || |.:|.
plant   280 GYVYNASEEPKILMTGKWNESMSYQP----CDGEGEPLPGT-ELKEVWKLADVPKD-DK-YQYTH 337

  Fly   676 LACQLNEEE---EGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAE 737
            .|.::|..:   :.:.|:|||||||:..:|.||..:|..||..:||:||.|:|.||.:.:
plant   338 FAHKINSFDTAPKKLLPSDSRLRPDRYALEMGDMSKSGYEKSSMEERQRAEKRTREEKGQ----- 397

  Fly   738 GRPYPAYEPMWFKREKEEGSEEY----VHVFKNTYWEAKAA 774
                 |:.|.||...:|..:..:    |:.|...|.|.:||
plant   398 -----AFTPKWFDVTEEVTATPWGDLEVYQFNGKYSEHRAA 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594
		PH_OSBP_ORP4	17..113	CDD:270101
		Oxysterol_BP	399..764	CDD:279564	126/373 (34%)
ORP3B	NP_187541.1	Oxysterol_BP	75..427	CDD:395990	127/375 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810