DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and osbp2a

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_001334384.3	Gene:	osbp2a / 794414	ZFINID:	ZDB-GENE-091113-18	Length:	739	Species:	Danio rerio

Alignment Length:	783	Identity:	363/783 - (46%)
Similarity:	489/783 - (62%)	Gaps:	83/783 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVISNGGT 82
            ||||.|||||:|||||||||||.|:|||||.|:|:.|||||||:|....|...::|.||:::||
Zfish    24 KGWLFKWTNYLKGYQRRWFVLSNGLLSYYRTQAEMAHTCRGTITLATVHIEVGETCHFVLTSGG- 87

  Fly    83 QTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQE-ISSVVRDLTDRLESM 146
            :::|:||.:|.|.|.||:||:.|||.|...:...::...|.....|.:. |...::.|..:||.:
Zfish    88 RSYHLKAYSEGECQRWVSALQQAKANATHMMPHSDDSGDEGPLAQPDRALIQGALKTLVSKLEDL 152

  Fly   147 RTCYDLITKHGAALQRALNDLETNEEESLGS-RTKIVNERATLFRITSNAMINAGNDYLHTAEAQ 210
            .||.:||.||||||||:|::||.....:.|: :.|.||||||||||||||||||..|::..||..
Zfish   153 STCNELIGKHGAALQRSLSELEDLRAPTDGTDKLKTVNERATLFRITSNAMINACQDFVDLAEGH 217

  Fly   211 GHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPVSSTSGAGT-AGSLVTSDEEM 274
            ..:|.:.|.:|||||..|||.|||:|||.:.:|:|   .|::....:.:..|| .|.....:|::
Zfish   218 SRRWQRALQYEREQRHHLEETIEQLAKQHNSLERA---WRESPSTHNQAAEGTLEGESSEENEDI 279

  Fly   275 EFFDAEEHGYSGSGRSPESSDCERGTFIL------KMHKRRSSSEDQVEGHLEGSSSESDEQKRT 333
            |||||.|.       ||        .||.      ..|:..||::....|.|..:.|:.|
Zfish   280 EFFDAMED-------SP--------AFITVPADNHSQHRLLSSNQSVTSGSLSSNWSQDD----- 324

  Fly   334 VQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPI 398
                            :.|.|.                  |       |.:.||.|:|||||:.:
Zfish   325 ----------------NDGSGS------------------Y-------LRRGRRRRIPDKPNYSL 348

  Fly   399 SLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVS 463
            :||.||||||||:|||||||:||||||||||||.||.||:|:||.||.|....||:..:|||:||
Zfish   349 NLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYSELLDRAARCDSSLEQMCLVAAFSVS 413

  Fly   464 AYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCES-KNWTCWQEFSMTS 527
            :|:||.:|.|||||||||||||.||:::||:|.:.||:|||||.||.|..| :.||.|||.::.|
Zfish   414 SYSTTVHRIGKPFNPLLGETYELDRLEEYGYRSICEQISHHPPAAAHHVISQRGWTLWQEITIDS 478

  Fly   528 KFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCI 592
            ||||||:.|.|||.::::|..||..|.|.|||:||:||||||||:||.|::.|...::.:  .|.
Zfish   479 KFRGKYISIMPLGNIHLKFHTSGNHYVWSKVTSTVHNIIVGKLWIDQSGDIIIVNHRSKD--TCH 541

  Fly   593 LNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTS----GS--VSSPTYTT 651
            |.|.|||||||||.|.|.|||.:.:....:::.||||.|:|.|.::::|    ||  .....|.|
Zfish   542 LKFSPYSYFSRDVPRKVTGVVTDGEGSAHYILSGTWDDKMESAKIIESSHACGGSEGKQKTVYQT 606

  Fly   652 GEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLRPDQRLMEQGDWDESNKEKLRL 716
            ...||.|::.|.|.:::..|.|::||..|||.|:|:|||||||||||||||.|.|||:|.||.||
Zfish   607 LPPKLLWKKYPLPENAENMYYFSSLALTLNELEDGIAPTDSRLRPDQRLMEAGLWDEANTEKQRL 671

  Fly   717 EEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCP 781
            ||:||.|||:|:.:|..|..||:....|:|:||.:..:..:.|...::|..|||||..|::..||
Zfish   672 EERQRLERRKRDAQANLALEEGKEVETYQPIWFMKRTDLETGESSFMYKGGYWEAKDRQDWSQCP 736

  Fly   782 DIY 784
            .|:
Zfish   737 AIF 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	53/88 (60%)
		PH_OSBP_ORP4	17..113	CDD:270101	56/94 (60%)
		Oxysterol_BP	399..764	CDD:279564	201/371 (54%)
osbp2a	XP_001334384.3	PH_OSBP_ORP4	23..118	CDD:270101	56/94 (60%)
osbp2a	XP_001334384.3	Oxysterol_BP	349..719	CDD:307410	201/371 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589794
Domainoid	1	1.000	444	1.000	Domainoid score	I509
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	725	1.000	Inparanoid score	I612
OMA	1	1.010	-	-		QHG48002
OrthoDB	1	1.010	-	-		D215020at33208
OrthoFinder	1	1.000	-	-		FOG0002531
OrthoInspector	1	1.000	-	-		otm24374
orthoMCL	1	0.900	-	-		OOG6_101373
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800