Protein Alignment Osbp and Osbpl3

DIOPT Version :9

• Sequence 1: NP_477271.1
• Gene: Osbp / 42985
• FlyBaseID: FBgn0020626
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001334142.1
• Gene: Osbpl3 / 71720
• MGIID: 1918970
• Length: 886
• Species: Mus musculus
• Alignment Length: 914
• Identity: 250/914 - (27%)
• Similarity: 382/914 - (41%)
• Gaps: 238/914 - (26%)

  Fly    15 PEMKGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGAL-----IHTVD 71
            |..||:||   ||.  :||:.:|:|.|.||:|.|.::|::|...     .|||.:     :.:|.
Mouse    51 PVQKGFLLKKRKWP--LKGWHKRFFCLEKGILKYAKSQADIERE-----KLHGCIDVGLSVMSVK 108

  Fly    72 SCTFVIS-NGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEISSV 135
            ..:..|. :.....:|:|..:|.....||:.|...:                   :....||:..
Mouse   109 KSSKCIDLDTEEHIYHLKVKSEELFDEWVSKLRHHR-------------------MYRQNEIAMF 154

  Fly   136 VRDLTDRLESMRTCYDLITKHGAALQRALNDLETNEEESLGSRTKIVNERATLFRITSNAMINAG 200
            .||:......                .::.|......||:.||.:....:...|...||...:.|
Mouse   155 PRDVNHFFSG----------------SSVTDSAPGVFESVSSRKRSSLSKQNSFPPGSNLSFSCG 203

  Fly   201 ND-----YLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQM-------------AKQQSQMEQAAV 247
            .|     :|.::|.. .|.||.:.|.......:.:::|.|             |.|....|...
Mouse   204 GDTRVPFWLQSSEDM-EKCSKDMAHCHAYLLEMSQLLESMDVLHRTYSAPAINAIQGGAFESPK- 266

  Fly   248 LVRQNKP----VSSTSGAGTAGSLV------------TSDEEMEFFD-AEEHGYS-GSGRSPESS 294
              ::.:|    .|...|....|:|.            :|:..:...| .||..|| ||..|.|.|
Mouse   267 --KEKRPHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFS 329

  Fly   295 DCE--------------RGTF------------ILKMHKRRSSSEDQVEGHLEGSSS----ESDE 329
            ..:              |..|            ::::....|.|. ||.|.....||    .:|.
Mouse   330 KMQEDLCHVAHKVYFALRSAFNSISVEREKLKQLMELDTSPSPSA-QVVGLKHALSSALAQNTDL 393

  Fly   330 QKRTVQTVQQVCLVSAPRVASGGQ----------------------------------------- 353
            ::|..:...:..|:..|.|...|.
Mouse   394 KERLRRIHAESLLLDPPAVPKPGDNLAEENSRDEGRALVHQLSNESRLSITDSLSEFFDAQEVLL 458

  Fly   354 ---------GDDDDDVDKALPAKESTDSIYGRNWNPDL-----------------IKKRRDRVP- 391
                     .|||..|      .:.:|::...|.:.||                 ..|||..:|
Mouse   459 SPSSSENEISDDDSYV------SDISDNLSLDNLSNDLDNERQTLGPVLESSGEARSKRRTSLPA 517

  Fly   392 DKPN-HPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLA 455
            ..|| ..:|||.|::|.|||||||:.||:..||||:.||||.|:.||:|:||.|:......|::.
Mouse   518 PGPNTSSVSLWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMV 582

  Fly   456 YIAAFTVSAYATTTNRTG-KPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTC 519
            |:|||.:||||::..|.| |||||:|||||||.|.|. |::..|||||||||::|.|.||.|:..
Mouse   583 YVAAFAISAYASSYFRAGSKPFNPVLGETYECIRQDK-GFQFFAEQVSHHPPISACHAESGNFVF 646

  Fly   520 WQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQ 584
            ||:....:||.||.::|.|:|..:|..|..|..:.|.|||:.::||:.|:.|::.:||::|:...
Mouse   647 WQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIDIKNLN 711

  Fly   585 AAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTY 649
            ....| |.:|||...|:|.:. ..::|.|.::..:....:.|.|...|       ..|..||.|
Mouse   712 DDSCH-CKVNFIKAKYWSTNA-HEIEGTVFDRSGKAVHRLFGKWHESI-------YCGGASSST- 766

  Fly   650 TTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNE----EEEGVAPTDSRLRPDQRLMEQGDWDESN 710
                  ..||..|.|...:::|.||..|.:|||    ....:.|||:|.||||||:|:|:.:|:.
Mouse   767 ------CVWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFRPDQRLLEEGNIEEAE 825

  Fly   711 KEKLRLEEKQRTERRR--RENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKA 773
            .:|.|:|:.|| ||||  .||..|           ::|.:|::..::     ..|...||.|.:.
Mouse   826 VQKQRIEKLQR-ERRRVLEENGVE-----------HQPRFFRKSSDD-----AWVSNGTYLELRK 873

  Fly   774 AQNF 777
            ...|
Mouse   874 DLGF 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	29/100 (29%)
		PH_OSBP_ORP4	17..113	CDD:270101	28/104 (27%)
		Oxysterol_BP	399..764	CDD:279564	146/371 (39%)
Osbpl3	NP_001334142.1	PH_ORP3_ORP6_ORP7	30..152	CDD:270104	30/126 (24%)
		Oxysterol_BP	526..870	CDD:366530	149/377 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850