DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and osbp

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_017210757.1	Gene:	osbp / 564372	ZFINID:	ZDB-GENE-090312-18	Length:	818	Species:	Danio rerio

Alignment Length:	862	Identity:	405/862 - (46%)
Similarity:	505/862 - (58%)	Gaps:	154/862 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVISNGGT 82
            ||||.|||||||||||||||||.|:|||||.|:|:.|||||||:|..|.|...|||.||||||||
Zfish    16 KGWLFKWTNYIKGYQRRWFVLSNGLLSYYRTQAEMGHTCRGTINLATANIAVEDSCNFVISNGGT 80

  Fly    83 QTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVP----------SQEISSVVR 137
            ||:|:||.:|||||.|:||||||||||.| ::.|.::..:.:  .|          :.|:.|.:|
Zfish    81 QTYHLKASSEVERQRWITALELAKAKAFR-MQAESDDSGDES--TPPAAGQGGGARNSEVQSTLR 142

  Fly   138 DLTDRLESMRTCYDLITKHGAALQRALNDLETNEEESLGSRT--KI--VNERATLFRITSNAMIN 198
            .|..::|.:.||.|||.|||:||||:|::|   |...||..|  ||  |.|||||||||||||||
Zfish   143 TLGSKVEDLSTCNDLIAKHGSALQRSLSEL---EGVRLGGETSEKIRQVTERATLFRITSNAMIN 204

  Fly   199 AGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQ----AAVL--VRQNKPVSS 257
            |..|:|..|:|...:|.|.|..|||||.||||.:||:|||.:.:|:    |.||  .:.|..:.|
Zfish   205 ACRDFLALAQAHSKRWQKALQAEREQRVRLEETLEQLAKQHNHLERAFRGATVLPPSQSNPAIDS 269

  Fly   258 TSGAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCER-GTFIL-----KMHKRRSSSEDQV 316
            .......|.....|||.|||||                ||. ..||.     |.|  ||.|
Zfish   270 KGSVPGKGDASDEDEENEFFDA----------------CEDVQEFITVPADPKYH--RSGS---- 312

  Fly   317 EGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPD 381
              ::.|.|||......|....:|       .:||..:.....:|   :|
Zfish   313 --NVSGISSEMGMDDGTTSLDEQ-------SMASNPESPQSQEV---VP---------------- 349

  Fly   382 LIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAAT 446
             ::|||.|:|||||:.::||.||||||||:|||||||:||||||||||||.||.||.|:||..|.
Zfish   350 -VRKRRTRIPDKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLSEDLEYYELLDRGAK 413

  Fly   447 CQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALH 511
            ||...||:.|:||||||:|:||.:|||||||||||||:|.||:.:.|:|.|.||||||||.||.|
Zfish   414 CQSSLEQMCYVAAFTVSSYSTTVHRTGKPFNPLLGETFELDRLQESGYRSLCEQVSHHPPAAAHH 478

  Fly   512 CES-KNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQH 575
            ..| :.||..||.::.|||||||:.|.|||.::..|..|...|:|:||||||:||||||||:||.
Zfish   479 AISERGWTLRQEIALASKFRGKYLSIMPLGSIHCIFEKSNNHYTWKKVTTTVHNIIVGKLWIDQS 543

  Fly   576 GEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKT 640
            ||::|...:.  |.:|.|.|.|||||||||.|.|.|||.:||.:..:|:.||||.|:|.:.|:::
Zfish   544 GEIDIVNHRT--GDRCHLKFAPYSYFSRDVARKVTGVVTDKDGKAHYVLSGTWDEKMECSRVMQS 606

  Fly   641 S-------GSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLRPDQ 698
            |       .......|.|.:.|..||:.|.|..::..|.|:|||..|||.||||||||||.||||
Zfish   607 SRGGENGADGRQKTVYQTLKAKELWRKTPLPEGAENMYYFSTLALTLNEPEEGVAPTDSRKRPDQ 671

  Fly   699 RLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAA--AEGR---------------------- 739
            ||||||.|:|:|.||.||||||||.||.||.||..:|  .||:
Zfish   672 RLMEQGRWEEANAEKQRLEEKQRTARREREREANRSANPEEGKEPADGAEEVEIATEPSETTDKT 736

  Fly   740 ----------------------------PYPA---------YEPMWFKREKEEGSEEYVHVFKNT 767
                                        ||.|         |:.|||.|..:..:.|..|:::..
Zfish   737 DTDETSSDLSLSTETLHGSHPPSYSMEGPYGAPVKSGHQDSYKAMWFDRCVDPMTGEPTHIYRGG 801

  Fly   768 YWEAKAAQNFEGCPDIY 784
            |||.|...|::.||||:
Zfish   802 YWETKEQGNWDSCPDIF 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	67/88 (76%)
		PH_OSBP_ORP4	17..113	CDD:270101	72/94 (77%)
		Oxysterol_BP	399..764	CDD:279564	216/433 (50%)
osbp	XP_017210757.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	444	1.000	Domainoid score	I509
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	725	1.000	Inparanoid score	I612
OMA	1	1.010	-	-		QHG48002
OrthoDB	1	1.010	-	-		D215020at33208
OrthoFinder	1	1.000	-	-		FOG0002531
OrthoInspector	1	1.000	-	-		otm24374
orthoMCL	1	0.900	-	-		OOG6_101373
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870