DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and osbp2b

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_021331891.1	Gene:	osbp2b / 561797	ZFINID:	ZDB-GENE-060526-3	Length:	822	Species:	Danio rerio

Alignment Length:	828	Identity:	401/828 - (48%)
Similarity:	517/828 - (62%)	Gaps:	110/828 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TDAAGNALAEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGAL 66
            |.|:|.  ...|....||||.|||||||||||||||||.|:|||||.|:|:.|||||||:|..|.
Zfish    60 TPASGT--PAPGSDTYKGWLFKWTNYIKGYQRRWFVLSNGLLSYYRTQAEMAHTCRGTINLATAH 122

  Fly    67 IHTVDSCTFVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAI------------------ 113
            |.|.|:|..|:|:|| :|:|:||.||||||.||||||||||||||.:
Zfish   123 IDTEDACNIVLSSGG-RTYHLKASTEVERQRWVTALELAKAKAIRMMNDQSDNGHTASLTHCYQS 186

  Fly   114 --ECEEEEETETAHVVPSQEISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLET-NEEESL 175
              ..:||..:::.|    .||...::.|..:|:.:.||.:||.||||||||:|::||| ......
Zfish   187 DDSADEEPTSQSDH----SEIQGTLKTLASKLDDLSTCNELIAKHGAALQRSLSELETLRVPLEG 247

  Fly   176 GSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQS 240
            |.:.|.||||||||||||||||||..|:|..||:...:|.::|.||||||..|||.|||:|||.:
Zfish   248 GEKIKAVNERATLFRITSNAMINACRDFLELAESHSRRWQRVLQHEREQRTHLEETIEQLAKQHN 312

  Fly   241 QMEQA---AVLVRQNKPVSSTSGAGTA-----GSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCE 297
            .:|:|   |.....|.|.:.|:..|.:     ......||:.|:|||.|.       ||
Zfish   313 SLERAWREAPAHAVNTPDTPTTDTGVSERPRKEEASDEDEDTEYFDAMED-------SP------ 364

  Fly   298 RGTFIL------KMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDD 356
              .||.      ..|:|..|       :|.|                          |||||..|
Zfish   365 --AFITVTATDPSQHRRSQS-------NLSG--------------------------ASGGQPSD 394

  Fly   357 ---DDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMP 418
               ||:      ...|::...|:...|.  :|||.|:.:|||:.::||.||||||||:|||||||
Zfish   395 WNQDDN------CSVSSNDFSGKELQPR--RKRRSRISEKPNYSLNLWSIMKNCIGKELSKIPMP 451

  Fly   419 INFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGET 483
            :||||||||||||.||.||.|:||.||.|::..||:..:|||:||:|:||.:||.||||||||||
Zfish   452 VNFNEPLSMLQRLTEDLEYHELLDKAARCENSLEQMCLVAAFSVSSYSTTVHRTAKPFNPLLGET 516

  Fly   484 YECDRMDDYGWRCLAEQVSHHPPVAALHCES-KNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFP 547
            ||.||::::|:|.|.||||||||.||.|..| :.|:.|||.::.|||||||:.|.|||.:::||.
Zfish   517 YELDRLEEFGYRSLCEQVSHHPPAAAHHVVSQRGWSLWQEITIASKFRGKYLSIMPLGAIHLQFH 581

  Fly   548 NSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGV 612
            .||..|.|||||:||:||||||||:||.|:::|...:..|  .|.|.|.|||||||:|.|.|.||
Zfish   582 ASGNHYVWRKVTSTVHNIIVGKLWIDQSGDIDIVNHRTKE--TCQLKFSPYSYFSREVPRKVTGV 644

  Fly   613 VMNKDNEVKWVVRGTWDMKIEIAPVLKTS-GSVSS-----PTYTTGEFKLAWRRRPAPPDSDKFY 671
            ||:.|.:..:::.||||.|:|.|.::::| ||.||     ..|.|...||.|::.|.|.:::..|
Zfish   645 VMDSDGQANYILSGTWDEKMESAKIVQSSRGSSSSEGKQKTVYQTLSPKLLWKKYPLPENAENMY 709

  Fly   672 NFTTLACQLNEEEEGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAA 736
            .|::||..|||||:||:.|||||||||||||.|.|||:|.||.|||||||..|||||.||..|..
Zfish   710 YFSSLALTLNEEEDGVSITDSRLRPDQRLMEAGRWDEANAEKQRLEEKQRAVRRRREAEASRAID 774

  Fly   737 EGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            ||..:..|:|:||.:..:|.:.|.:.|:|..|||||..|::..||:|:
Zfish   775 EGEDFEGYKPLWFHQTTDEMTGENIFVYKGGYWEAKDRQDWSMCPEIF 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	64/91 (70%)
		PH_OSBP_ORP4	17..113	CDD:270101	70/95 (74%)
		Oxysterol_BP	399..764	CDD:279564	211/371 (57%)
osbp2b	XP_021331891.1	PH_OSBP_ORP4	73..168	CDD:270101	70/95 (74%)
osbp2b	XP_021331891.1	Oxysterol_BP	432..802	CDD:307410	211/371 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	444	1.000	Domainoid score	I509
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75303
Inparanoid	1	1.050	725	1.000	Inparanoid score	I612
OMA	1	1.010	-	-		QHG48002
OrthoDB	1	1.010	-	-		D215020at33208
OrthoFinder	1	1.000	-	-		FOG0002531
OrthoInspector	1	1.000	-	-		otm24374
orthoMCL	1	0.900	-	-		OOG6_101373
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870