DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Osbp and OSBP

DIOPT Version :9

Sequence 1:NP_477271.1 Gene:Osbp / 42985 FlyBaseID:FBgn0020626 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_002547.1 Gene:OSBP / 5007 HGNCID:8503 Length:807 Species:Homo sapiens


Alignment Length:808 Identity:389/808 - (48%)
Similarity:506/808 - (62%) Gaps:101/808 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TDAAGNALAEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGAL 66
            |..:|.:.|.......:|||.|||||||||||||||||.|:|||||:::|:.|||||||:|..|.
Human    76 TGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATAN 140

  Fly    67 IHTVDSCTFVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAI-ECEEEEETETAHVVPSQ 130
            |...|||.|:|||||.||:|:||.:|||||.||||||||||||::.: |.:|..:.|:.......
Human   141 ITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKT 205

  Fly   131 EISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLETNE--EESLGSRTKIVNERATLFRITS 193
            |:.:.:|.|:.::|.:.||.|||.|||.||||:|::||:.:  .|| ..:.|.||||||||||||
Human   206 ELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAES-NEKIKQVNERATLFRITS 269

  Fly   194 NAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQA---AVLVRQNKPV 255
            ||||||..|:|..|:....||.|.|.:||:||.||||.:||:|||.:.:|:|   |.::..|.|.
Human   270 NAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPG 334

  Fly   256 SSTSG----AGTAGSLVTSDEEMEFFDAEE---------HGYSGSGRSPESSDCERGTFILKMHK 307
            :..||    ....|.:...|:|.|||||.|         |..:||..|..|||.           
Human   335 NVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDI----------- 388

  Fly   308 RRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDS 372
               |.::|.:..||    |:.::|||                                       
Human   389 ---SLDEQYKHQLE----ETKKEKRT--------------------------------------- 407

  Fly   373 IYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEY 437
                            |:|.|||:.::||.||||||||:|||||||:||||||||||||.||.||
Human   408 ----------------RIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEY 456

  Fly   438 TEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVS 502
            .|:||.||.|::..|||.|:||||||:|:||..||.||||||||||:|.||:::.|:|.|.||||
Human   457 HELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVS 521

  Fly   503 HHPPVAALHCESKN-WTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNII 566
            ||||.||.|.|||| ||..||..:||||||||:.|.|||.::..|..:|..|:|:||||||:|||
Human   522 HHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNII 586

  Fly   567 VGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMK 631
            |||||:||.||::|...:.  |.||.|.|:|||||||||.|.|.|.|.:...:|.:.:.||||.|
Human   587 VGKLWIDQSGEIDIVNHKT--GDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEK 649

  Fly   632 IE---IAPVL-KTSGSVSSPTYTTGEFK-LAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTD 691
            :|   :.||: :..|......:...|.: :.|:|.|.|.:::..|.|:.||..||..|.|.||||
Human   650 MECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTD 714

  Fly   692 SRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEG 756
            |||||||||||.|.|||:|.||.|||||||..|::||.||.:|..:|.||..|:.:||:|:|:..
Human   715 SRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPV 779

  Fly   757 SEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            ::|..|:::..|||.|..|::..||||:
Human   780 TKELTHIYRGEYWECKEKQDWSSCPDIF 807

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
OsbpNP_477271.1 PH 15..107 CDD:278594 64/91 (70%)
PH_OSBP_ORP4 17..113 CDD:270101 68/95 (72%)
Oxysterol_BP 399..764 CDD:279564 210/370 (57%)
OSBPNP_002547.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 61..86 3/9 (33%)
PH_OSBP_ORP4 91..189 CDD:270101 68/97 (70%)
PH 91..181 CDD:278594 64/89 (72%)
Phosphatidylinositol 4-phosphate binding. /evidence=ECO:0000250|UniProtKB:P35844 117..122 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..353 5/23 (22%)
FFAT. /evidence=ECO:0000269|PubMed:24209621 358..364 5/5 (100%)
Sterol binding. /evidence=ECO:0000250 406..457 39/105 (37%)
Oxysterol_BP 418..787 CDD:279564 210/370 (57%)
Phosphatidylinositol 4-phosphate binding. /evidence=ECO:0000250|UniProtKB:P35844 493..496 2/2 (100%)