DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and Osbpl3

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_006236577.1	Gene:	Osbpl3 / 362360	RGDID:	1564287	Length:	886	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	253/907 - (27%)
Similarity:	384/907 - (42%)	Gaps:	224/907 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PEMKGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEI-NHTCRGTISLHGALIHTVDSCTF 75
            |..||:||   ||.  :||:.:|:|.|.||:|.|.::|::| .....|:|.:..:::....|...
  Rat    51 PAQKGFLLKKRKWP--LKGWHKRFFCLEKGILKYAKSQTDIEREKLHGSIDVGLSVMSVKKSSKC 113

  Fly    76 VISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEISSVVRDLT 140
            :..:.....:|:|..:|.....||:.|...:                   :....||:...||:.
  Rat   114 IDLDTEEHIYHLKVKSEDVFDEWVSKLRHHR-------------------MYRQNEIAMFPRDVN 159

  Fly   141 DRLESMRTCYDLITKHGAALQRALNDLETNEEESLGSRTKIVNERATLFRITSNAMINAGND--- 202
            .....                .::.|......||:.||.:....:...|...||...:.|.|
  Rat   160 HFFPG----------------SSVTDSAPGVFESVSSRKRSSLSKQNSFPAGSNLSFSCGGDTRV 208

  Fly   203 --YLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQM-------------AKQQSQMEQAAVLVRQN 252
              :|.::|.. .|.||.|.|.......:.:::|.|             |.|....|......|.:
  Rat   209 PFWLQSSEDM-EKCSKDLAHCHTYLLEMSQLLESMDVLHRTYSAPAINAIQGGAFESPKKEKRSH 272

  Fly   253 KPVSSTS-GAGTAGSLV------------TSDEEMEFFD-AEEHGYS-GSGRSPESSDCE----- 297
            :...|.: |....|.|.            :|:..:...| .||..|| ||..|.|.|..:
  Rat   273 RRWRSRAIGKDAKGMLQVPKPFSGPVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFSKMQEDLCH 337

  Fly   298 ---------RGTF-ILKMHKRR----------SSSEDQVEGHLEGSSS----------------- 325
                     |..| .:.|.:.:          ||...||.|.....||
  Rat   338 VAHKVYFALRSAFNSISMEREKLKQLMELDTSSSPSAQVVGLKHALSSALAQNTDLKERLRRIHA 402

  Fly   326 ES---------------------DEQKRTVQTV------------------QQVCLVSAPRVASG 351
            ||                     ||.:..|..:                  |:|.|  :|..:..
  Rat   403 ESLLLDPPAGPKPGDNLAEEISRDESRALVHQLSNESRLSITDSLSEFFDAQEVLL--SPSSSEN 465

  Fly   352 GQGDDDDDVDKALPAKESTDSIYGRNWNPDL-----------------IKKRRDRVP-DKPN-HP 397
            ...|||..|      .:.:|::...|.:.||                 ..|||..:| ..|| ..
  Rat   466 EISDDDSYV------SDISDNLSLDNLSNDLDNERQTLGPVLESSGEARSKRRTSLPAPGPNTSS 524

  Fly   398 ISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTV 462
            :|:|.|::|.|||||||:.||:..||||:.||||.|:.||:|:||.||......|::.|:|||.:
  Rat   525 VSVWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAHMPSPLERMVYVAAFAI 589

  Fly   463 SAYATTTNRTG-KPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMT 526
            ||||::..|.| |||||:|||||||.|.|. |::..|||||||||::|.|.||:|:..||:....
  Rat   590 SAYASSYFRAGSKPFNPVLGETYECIRQDK-GFQFFAEQVSHHPPISACHAESRNFVFWQDVRWK 653

  Fly   527 SKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKC 591
            :||.||.::|.|:|..:|..|..|..:.|.|||:.::||:.|:.|::.:||:.|:..:....| |
  Rat   654 NKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLRDDSCH-C 717

  Fly   592 ILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEFKL 656
            .:|||...|:|.:. ..::|.|.::..:....:.|.|...|       ..|..||.|       .
  Rat   718 KVNFIKAKYWSTNA-HEIEGTVFDRSGKAVHRLFGKWHESI-------YCGGASSST-------C 767

  Fly   657 AWRRRPAPPDSDKFYNFTTLACQLNE----EEEGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLE 717
            .||..|.|...:::|.||..|.:|||    ....:.|||:|.||||||:|:|:.:|:..:|.|:|
  Rat   768 VWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFRPDQRLLEEGNIEEAEVQKQRIE 832

  Fly   718 EKQRTERRR--RENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNF 777
            :.|| ||||  .||..|           ::|.:|::..::     ..|...||.|.:....|
  Rat   833 KLQR-ERRRVLEENGVE-----------HQPRFFRKSSDD-----AWVSNGTYLELRKDLGF 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	27/95 (28%)
		PH_OSBP_ORP4	17..113	CDD:270101	26/99 (26%)
		Oxysterol_BP	399..764	CDD:279564	146/371 (39%)
Osbpl3	XP_006236577.1	PH_ORP3_ORP6_ORP7	30..152	CDD:270104	28/121 (23%)
Osbpl3	XP_006236577.1	Oxysterol_BP	526..870	CDD:395990	149/377 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920