DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Osbp and osbpl2b

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_005162004.1	Gene:	osbpl2b / 334206	ZFINID:	ZDB-GENE-030131-6138	Length:	473	Species:	Danio rerio

Alignment Length:	451	Identity:	171/451 - (37%)
Similarity:	234/451 - (51%)	Gaps:	76/451 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 IKKRRDRVPDK--PNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAA 445
            |||||..:|..  ..:..|:|.|:|.|||.:||||.|||.||||||.||||.|..|:|.:|..|.
Zfish    50 IKKRRSCLPAPMFSRNDFSVWSILKKCIGLELSKITMPIVFNEPLSFLQRLTEYMEHTYLLQKAC 114

  Fly   446 TCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAAL 510
            ...|..|::..:|||.|||.|:..:|||||||||||||||..| :|.|:|.::||||||||::|.
Zfish   115 LQSDSIERMQTVAAFAVSAVASQWDRTGKPFNPLLGETYELTR-EDQGFRLISEQVSHHPPISAF 178

  Fly   511 HCES--KNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVD 573
            |.||  .::..........||.||.|:..|.|.:.::.......|:|......|:|:|:||||::
Zfish   179 HTESLMGDFVFHGSIYPKLKFWGKSVEAEPKGTITLELHKHKEAYTWTNPFCCVHNVILGKLWIE 243

  Fly   574 QHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTW---------- 628
            |:|.:||  ...:.|.||:|||.|...|.:::.| |:|.:.:|..:.:.|:.|.|
Zfish   244 QYGTVEI--INHSTGEKCVLNFKPCGMFGKELHR-VEGYIQDKSKKKRCVIYGKWTECMWSVDPQ 305

  Fly   629 --------------DMK---------------IEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAP 664
                          |.|               .|:..|.:|...:...|       |.||....|
Zfish   306 AYEAHRKLEKKGTTDTKKQKQQEEPEAVNEDADEMPEVQETVAVIPGST-------LLWRISSRP 363

  Fly   665 PDSDKFYNFTTLACQLNEEEEG----VAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERR 725
            |.|.:.||||..|..|||.|.|    :||||.|||||.|.||.|:.||:::||.|||||||..|:
Zfish   364 PLSAEMYNFTNFAMALNELEPGMEGVLAPTDCRLRPDIRAMENGNMDEASREKERLEEKQRAARK 428

  Fly   726 RRENEAEEAAAEGRPYPAYEPMWFK--REKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            .|....||          :...||:  .....||:::  ::...|::.|    :..|||||
Zfish   429 ERAKNEEE----------WSTRWFQLGTNPYTGSQDW--LYTGGYFDRK----YRNCPDIY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594
		PH_OSBP_ORP4	17..113	CDD:270101
		Oxysterol_BP	399..764	CDD:279564	158/411 (38%)
osbpl2b	XP_005162004.1	Oxysterol_BP	68..457	CDD:279564	158/411 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840