DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and Osbp2

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_038947935.1	Gene:	Osbp2 / 305475	RGDID:	1310505	Length:	974	Species:	Rattus norvegicus

Alignment Length:	859	Identity:	380/859 - (44%)
Similarity:	519/859 - (60%)	Gaps:	112/859 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AAGNALAEKGLP-------EMKGWLLKWTNYIKGYQRRWFVLSKGVLSYY-------------RN 48
            :||:.::...:|       ..||||.|||||:||||||||||..|:||||             ||
  Rat   150 SAGSPVSGTSVPMVSPPLDSYKGWLFKWTNYLKGYQRRWFVLGNGLLSYYRCIQDGITESPLGRN 214

  Fly    49 QSEINHTCRGTISLHGALIHTVDSCTFVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAI 113
            |.|:.|||||||:|..|...|.|||..::.| |.:|:|:||.:||:||.|:|.||||||||||.:
  Rat   215 QGEMAHTCRGTINLASAHFETEDSCGILLCN-GARTYHLKASSEVDRQQWITVLELAKAKAIRVM 278

  Fly   114 ECEE----EEETETAHVVPSQEISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLETNE--E 172
            ..:.    :::.|.|....:.::...::.|:.:|:.:.||.|||.||||||||:||:|::.:  .
  Rat   279 NTQSDDSGDDDEEPAAPADNSDLHHTLKTLSLKLDDLGTCNDLIAKHGAALQRSLNELDSLKIPS 343

  Fly   173 ESLGSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAK 237
            || |.:.|:||||||||||||||||||..|:|..||....||.:.|::|:|||..|||.|||:||
  Rat   344 ES-GEKLKVVNERATLFRITSNAMINACKDFLELAEIHSRKWQRALNYEQEQRVHLEETIEQLAK 407

  Fly   238 QQSQMEQAAVLVRQNKP--VSSTSGAGTAGSLVTS-------DEEMEFFDAEEHGYSGSGRSPES 293
            |.:.:|:|..    |.|  .:|:|.:.:.||.:||       ||:.|:|||.|...|
  Rat   408 QHNSLERAFC----NTPGGPASSSKSFSEGSFLTSKGENSEEDEDTEYFDAMEDSTS-------- 460

  Fly   294 SDCERGTFILKMHKRRS-----------------SSEDQVEGHLEGSSS-------------ESD 328
                   ||..:.:.:.                 ||..:|.|.::.::|             .:.
  Rat   461 -------FITVITEAKEDSNIINPYGSATRVNLLSSSPRVLGSIQSTASCPSPEALAAWLSHTAH 518

  Fly   329 EQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNP-DLIK-KRRDRVP 391
            .|....:..|..|....|   .||.|....|...|...:|..|   |.::.| |..| |||.|:|
  Rat   519 PQAPRARAHQPQCPCRKP---EGGPGTTSVDWTSADNVREVLD---GASFMPKDSCKVKRRVRIP 577

  Fly   392 DKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAY 456
            ||||:.::||.|||||||::||:||||:||||||||||||.||.||..:||.|..|....||:..
  Rat   578 DKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCL 642

  Fly   457 IAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKN-WTCW 520
            :|||:||:|:||.:|..|||||:||||:|.||::|.|.|.|.||||||||.||.|..||: |:.|
  Rat   643 VAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLEDMGLRSLCEQVSHHPPSAAHHVFSKHGWSLW 707

  Fly   521 QEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQA 585
            ||.::.|||||||:.|.|||.::::|..||..|.|||.|:||:||||||||:||.|::||...:.
  Rat   708 QEITIASKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKT 772

  Fly   586 AEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGS---VSSP 647
            .:  :|.|.|:||||||::..|.|.|||.:...:..:|:.|:||.::|.:.::.:|.|   ....
  Rat   773 KD--RCQLKFVPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKIVHSSPSSDGKQKT 835

  Fly   648 TYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLRPDQRLMEQGDWDESNKE 712
            .|.|...||.||:.|.|.:::..|.|:.||..|||:|||||||||||||||||||:|.|||:|.|
  Rat   836 VYQTLPAKLLWRKYPLPENAENMYYFSELALTLNEQEEGVAPTDSRLRPDQRLMERGRWDEANTE 900

  Fly   713 KLRLEEKQRTERRRRENEA-------EEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWE 770
            |.|||||||..||||....       ||..::|     |.|:||::..:..:.|...::|..|||
  Rat   901 KQRLEEKQRLNRRRRLESCTAGCGGEEEKESDG-----YSPLWFEKRLDPLTGEMACIYKGGYWE 960

  Fly   771 AKAAQNFEGCPDIY 784
            ||..:::..||:|:
  Rat   961 AKEKKDWHMCPNIF 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	58/111 (52%)
		PH_OSBP_ORP4	17..113	CDD:270101	63/108 (58%)
		Oxysterol_BP	399..764	CDD:279564	194/375 (52%)
Osbp2	XP_038947935.1	PHA03247	<25..161	CDD:223021	2/10 (20%)
		PH_OSBP_ORP4	170..278	CDD:270101	63/108 (58%)
		Oxysterol_BP	585..960	CDD:395990	196/381 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	435	1.000	Domainoid score	I551
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75303
Inparanoid	1	1.050	668	1.000	Inparanoid score	I710
OMA	1	1.010	-	-		QHG48002
OrthoDB	1	1.010	-	-		D215020at33208
OrthoFinder	1	1.000	-	-		FOG0002531
OrthoInspector	1	1.000	-	-		otm45096
orthoMCL	1	0.900	-	-		OOG6_101373
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880