DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and OSBPL3

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_056365.1	Gene:	OSBPL3 / 26031	HGNCID:	16370	Length:	887	Species:	Homo sapiens

Alignment Length:	906	Identity:	247/906 - (27%)
Similarity:	391/906 - (43%)	Gaps:	222/906 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PEMKGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGAL-----IHTVD 71
            |..||:||   ||.  :||:.:|:|.|.||:|.|.::|::|...     .|||.:     :.:|.
Human    52 PVQKGFLLKKRKWP--LKGWHKRFFYLDKGILKYAKSQTDIERE-----KLHGCIDVGLSVMSVK 109

  Fly    72 SCTFVIS-NGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEISSV 135
            ..:..|. :.....:|:|..:|.....||:.|...:                   :....||:..
Human   110 KSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHR-------------------MYRQNEIAMF 155

  Fly   136 VRDLTDRLESMRTCYDLITKHGAALQRALNDLETNEEESLGSRTKIVNERATLFRITSNAMINAG 200
            ..::......                ..:.|..:...:|:.||.:....:..||:..||...:.|
Human   156 PHEVNHFFSG----------------STITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCG 204

  Fly   201 ND-----YLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQM-------------AKQQSQMEQAAV 247
            .:     :|.::|.. .|.||.|.|.......:.::::.|             |.|....|....
Human   205 GETRVPLWLQSSEDM-EKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKK 268

  Fly   248 LVRQNKPVSSTS-GAGTAGSLV------------TSDEEMEFFD-AEEHGYS-GSGRSPESSDCE 297
            ..|.::...|.: |....|:|.            :|:..:...| .||..|| ||..|.|.|..:
Human   269 EKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQ 333

  Fly   298 --------------RGTFILKMHKRR-----------SSSEDQVEGHLEGSSS----ESDEQKRT 333
                          |..|.:...:|.           ||...||.|.....||    .:|.::|.
Human   334 EDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERL 398

  Fly   334 VQTVQQVCLVSAPRVASGGQG---DDDDDVDKAL----------------------------PA- 366
            .:...:..|:.:|.||..|..   ::..|.::||                            |:
Human   399 RRIHAESLLLDSPAVAKSGDNLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSS 463

  Fly   367 ------------KESTDSIYGRNWNPDLIKKR---------------RDRV------PDKPNHPI 398
                        .:.:|::...|.:.||..:|               |.|.      |...|  |
Human   464 SENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSN--I 526

  Fly   399 SLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVS 463
            |||.|::|.|||||||:.||:..||||:.||||.|:.||:|:||.||......|::.|:|||.:|
Human   527 SLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAIS 591

  Fly   464 AYATTTNRTG-KPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTS 527
            |||::..|.| |||||:|||||||.| :|.|::..:||||||||::|.|.||:|:..||:....:
Human   592 AYASSYYRAGSKPFNPVLGETYECIR-EDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKN 655

  Fly   528 KFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCI 592
            ||.||.::|.|:|..:|..|..|..:.|.|||:.::||:.|:.|::.:||:.|:... .:...|.
Human   656 KFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLH-DDSCYCK 719

  Fly   593 LNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEFKLA 657
            :|||...|:|.:. ..::|.|.::..:....:.|.|...|...     .||.|:         ..
Human   720 VNFIKAKYWSTNA-HEIEGTVFDRSGKAVHRLFGKWHESIYCG-----GGSSSA---------CV 769

  Fly   658 WRRRPAPPDSDKFYNFTTLACQLNEEEEG----VAPTDSRLRPDQRLMEQGDWDESNKEKLRLEE 718
            ||..|.|...:::|:||..|.:|||.:..    :.|||:|.|||||.:|:|:.:|:..:|.|:|:
Human   770 WRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQ 834

  Fly   719 KQRTERRR--RENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNF 777
            .|| ||||  .||..|           ::|.:|::     |::...|...||.|.:....|
Human   835 LQR-ERRRVLEENHVE-----------HQPRFFRK-----SDDDSWVSNGTYLELRKDLGF 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	29/100 (29%)
		PH_OSBP_ORP4	17..113	CDD:270101	28/104 (27%)
		Oxysterol_BP	399..764	CDD:279564	144/371 (39%)
OSBPL3	NP_056365.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		PH_ORP3_ORP6_ORP7	31..153	CDD:270104	30/126 (24%)
		FFAT 1. /evidence=ECO:0000269\|PubMed:25447204	161..167		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..326		14/64 (22%)
		FFAT 2. /evidence=ECO:0000269\|PubMed:25447204	450..454		0/3 (0%)
		Oxysterol_BP	527..871	CDD:395990	147/377 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820