Protein Alignment Osbp and Osbpl1a

DIOPT Version :10

• Sequence 1: NP_477271.1
• Gene: Osbp / 42985
• FlyBaseID: FBgn0020626
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_038952524.1
• Gene: Osbpl1a / 259221
• RGDID: 628888
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 835
• Identity: 251/835 - (30%)
• Similarity: 389/835 - (46%)
• Gaps: 166/835 - (19%)

  Fly     6 GN-ALAEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTC--RGTISLHGAL- 66
            || .:..|.|...:|.|.|.:.:. |::..|.||..||||:||.|.:..|..  :|...|..|:
  Rat   227 GNKQVVHKALKRFEGPLWKSSRFF-GWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVC 290

  Fly    67 -IHTVDSCTFVIS--NGGTQTFHI-KAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVV 127
             :...|.|.|.:.  :.....|.: |...:..|:.|:.|:|  :..|.....|.:::.|:.
  Rat   291 TVKPTDGCLFSVRCFDDTVHGFRVPKNSLQQSREKWLEAIE--EHSAYSTHYCSQDQVTDD---- 349

  Fly   128 PSQEISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLETNEE--ESLGSRTKIVNERATLFR 190
            ..::::|.: ||.:.|...:||...:.|......:.:.:.:..::  .|...:..:::|.:   |
  Rat   350 EEEDVASAM-DLKESLARAQTCQQRLDKEIYNFLKMIKECDVAKDMLPSFLQKADVLSEAS---R 410

  Fly   191 ITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPV 255
            .|..|:.:..|.:......:..|    |..|:|:.:.|.|.:|.:|.:..::|::  ||..:.||
  Rat   411 ETCVALSDCLNLFTKQEGVRNFK----LEQEQEKNKILSEALETLATEHHELERS--LVEGSPPV 469

  Fly   256 SSTSGAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHL 320
            |..|             |.||:||    .||| .|..|..|      |:....|:..|::|..:
  Rat   470 SILS-------------EDEFYDA----LSGS-ESEGSLTC------LEAVTARAFEENEVPAN- 509

  Fly   321 EGSSSESDEQKRTVQTVQQVCLVSAPRVASG---GQGDDDDDVDKALPAKESTDSIYGRNWNPDL 382
            .|..                      |::.|   |.||       ||               .:.
  Rat   510 SGKH----------------------RMSEGKDCGGGD-------AL---------------SNG 530

  Fly   383 IKKRRDRVPDK--PNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAA 445
            |||.|..:|..  ..:..|:|.|::.|||.:||||.||:.||||||.||||.|..|:|.::..|:
  Rat   531 IKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKAS 595

  Fly   446 TCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAAL 510
            :..|..|::..:|||.|||.|:...|||||||||||||||..| ||.|:|.::||||||||::|.
  Rat   596 SFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVR-DDLGFRLISEQVSHHPPISAF 659

  Fly   511 HCESKNWTCWQEFSMTS------KFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGK 569
            |.|..|    .:|....      ||.||.|:..|.|.:.::.......|:|...|..|:||||||
  Rat   660 HAEGLN----NDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGK 720

  Fly   570 LWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTW-DMKIE 633
            ||::|:|.:||...:.  |.||:|||.|...|.:::.: |:|.:.:|..:....:.|.| :....
  Rat   721 LWIEQYGNVEIINHKT--GDKCVLNFKPCGLFGKELHK-VEGYIQDKSKKKLCALYGKWTECLYS 782

  Fly   634 IAPVL--------------KTSGSVSSPTYTTGEF--------------KLAWRRRPAPPDSDKF 670
            :.|..              |.:...:|.:..:.|.              .|.||..|.||:|.:.
  Rat   783 VDPATFDAYKKNDKKNTEEKKNSKQASASEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQM 847

  Fly   671 YNFTTLACQLNE---EEEGVAP-TDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEA 731
            ||||:.|..|||   |.|.|.| ||.|||||.|.||.|:.|::::||.|||||||..|:.|....
  Rat   848 YNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSE 912

  Fly   732 EEAAAEGRPYPAYEPMWFKR--EKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY 784
            |:          ::..||.:  ....|::::  ::..:||:    :|:...||||
  Rat   913 ED----------WKTRWFHQGPNPYSGAQDW--IYSGSYWD----RNYFNLPDIY 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH_OSBP_ORP4	17..113	CDD:270101	28/102 (27%)
		Oxysterol_BP	399..773	CDD:460126	156/414 (38%)
Osbpl1a	XP_038952524.1	ANKYR	<1..226	CDD:440430
		ANK repeat	43..78	CDD:293786
		ANK repeat	80..111	CDD:293786
		ANK repeat	175..206	CDD:293786
		PH_ORP1	230..353	CDD:270102	32/129 (25%)
		Oxysterol_BP	549..944	CDD:460126	156/418 (37%)