Protein Alignment Osbp and OSBPL6

DIOPT Version :9

• Sequence 1: NP_477271.1
• Gene: Osbp / 42985
• FlyBaseID: FBgn0020626
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_016858754.1
• Gene: OSBPL6 / 114880
• HGNCID: 16388
• Length: 981
• Species: Homo sapiens
• Alignment Length: 957
• Identity: 247/957 - (25%)
• Similarity: 391/957 - (40%)
• Gaps: 293/957 - (30%)

  Fly    18 KGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVIS- 78
            :|::|   ||.  :||:.:|:|||..|:|.|.:...:|.   :|.:  ||    ::|....|:|
Human   112 EGFMLKKRKWP--LKGWHKRFFVLDNGMLKYSKAPLDIQ---KGKV--HG----SIDVGLSVMSI 165

  Fly    79 ---------NGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEI-- 132
                     :.....:|:|..::....:||:  :|...:..|..|........:.|:.||...
Human   166 KKKARRIDLDTEEHIYHLKVKSQDWFDAWVS--KLRHHRLYRQNEIVRSPRDASFHIFPSTSTAE 228

  Fly   133 ---------------------------------------SSVVRDLTDRLESMRTCYDL------ 152
                                                   |.|...|.|..|..|...||
Human   229 SSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSN 293

  Fly   153 ------ITKHGAALQRA-----LNDLETN---------------EEESLGSRTKI---------- 181
                  :.::...|||.     ..|::.|               ..:|:...|||
Human   294 LVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKG 358

  Fly   182 ------------------VNERATLFRI---TSNA-----------------MINAGNDYLHTAE 208
                              |...||:..:   :||.                 .:.:..||....|
Human   359 QFSTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQE 423

  Fly   209 ---------------------AQGHKWSKMLHHEREQ----------RQRLEEIIEQMAKQQSQM 242
                                 .:..|..:|:..:...          ||.|.:.:.|.|:.:|::
Human   424 EFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRL 488

  Fly   243 ----------------------EQAAVLVRQNKPVSSTSGAGTAGSLVTSDEEMEFFDAEEHGYS 285
                                  ::|...:..:.|:|..  ......|..|:...|||||:|...|
Human   489 NRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQ--VANESRLSMSESVSEFFDAQEVLLS 551

  Fly   286 GSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVAS 350
            .|....|:||.|  ::|       |...|.:.   |.::|.:|...|.:...:    ::.....:
Human   552 ASSSENEASDDE--SYI-------SDVSDNIS---EDNTSVADNISRQILNGE----LTGGAFRN 600

  Fly   351 GGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKI 415
            |.:.        .|||.                      .||..|  |:||.|::|.|||||||:
Human   601 GRRA--------CLPAP----------------------CPDTSN--INLWNILRNNIGKDLSKV 633

  Fly   416 PMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTG-KPFNPL 479
            .||:..||||:.||.|.|:.||:|:||.|:...|..|::..:|||.||.|.:|..|.| |||||:
Human   634 SMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPV 698

  Fly   480 LGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYV 544
            |||||||.| :|.|:|..:||||||||::|.||||||:..||:....:||.||.::|.|:|.:.|
Human   699 LGETYECIR-EDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNV 762

  Fly   545 QFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCI--LNFIPYSYFSRDVQR 607
            ..|..|..|.|.||||.::||:.|:.|::.:||:.||.::::   .||  |.|:..:|::.:: .
Human   763 MLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSS---VCICKLTFVKVNYWNSNM-N 823

  Fly   608 SVKGVVMNKDNEVKWVVRGTW--DMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKF 670
            .|:|||::::.:..:.:.|.|  .:...:||                ..|..||....|.:.:.:
Human   824 EVQGVVIDQEGKAVYRLFGKWHEGLYCGVAP----------------SAKCIWRPGSMPTNYELY 872

  Fly   671 YNFTTLACQLNEEE----EGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERR-RRENE 730
            |.||..|.:|||.:    :.:.|||:|.|||||.:|:|:.:.:..||.|:||.||:.|| ..||.
Human   873 YGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENN 937

  Fly   731 AEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNF 777
            .|           :.|.:||:..:....| ..|..:||||.:....|
Human   938 LE-----------HIPKFFKKVIDANQRE-AWVSNDTYWELRKDPGF 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	25/101 (25%)
		PH_OSBP_ORP4	17..113	CDD:270101	26/107 (24%)
		Oxysterol_BP	399..764	CDD:279564	146/374 (39%)
OSBPL6	XP_016858754.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820