DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and osbp2

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_002931752.2	Gene:	osbp2 / 100491200	XenbaseID:	XB-GENE-6043707	Length:	808	Species:	Xenopus tropicalis

Alignment Length:	804	Identity:	398/804 - (49%)
Similarity:	508/804 - (63%)	Gaps:	88/804 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCT 74
            |..|....||||.|||||:|||||||||||.|:|||||.|:|:.|||||||:|..|.|.|.|||.
Frog    64 ASPGQDTYKGWLFKWTNYLKGYQRRWFVLSNGLLSYYRTQAEMAHTCRGTINLSTAHIDTEDSCN 128

  Fly    75 FVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAI--ECEEEEETETAHVVPSQEISSVVR 137
            .|::||| :|:|:||..|||||.||||||||||||||.:  :.::..:.|.:......|:.|.::
Frog   129 IVLTNGG-RTYHLKASCEVERQRWVTALELAKAKAIRMMNNQSDDSGDEEPSSQSDKSELHSSLK 192

  Fly   138 DLTDRLESMRTCYDLITKHGAALQRALNDLETNE--EESLGSRTKIVNERATLFRITSNAMINAG 200
            .||.:|:.:.||.|||.||||||||:|::||..:  .|| |.:.|.||||||||||||||||||.
Frog   193 ALTSKLDDLSTCNDLIAKHGAALQRSLSELENLKLPAES-GEKIKSVNERATLFRITSNAMINAC 256

  Fly   201 NDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKP--VSSTSGA-- 261
            .|:|..||....||.:.|.:|||||.||||.|||:|||.:.:|:|.    :..|  .|:|:|.
Frog   257 RDFLDLAETHSRKWHRALQYEREQRVRLEETIEQLAKQHNSLERAC----RGAPGLTSNTTGVLN 317

  Fly   262 -------GTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFIL-----KMHKRRSSSED 314
                   ...|.....|||.|:|||.|               :...||.     |.|:|
Frog   318 TPKGNVPAIKGEASDEDEETEYFDAME---------------DAPAFITVTADPKQHRR------ 361

  Fly   315 QVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWN 379
                  .||:..|                     ||||..||....|.|..:...::....|.
Frog   362 ------SGSNLSS---------------------ASGGHPDDWHLEDNAFHSSPESNHESKRK-- 397

  Fly   380 PDLI--KKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILD 442
             :||  |:||.|:|||||:.::||.||||||||:|||||||:||||||||||||.||.||.|:||
Frog   398 -ELIPKKRRRTRIPDKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLD 461

  Fly   443 YAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPV 507
            .|..|:...||:.:||||:||:|:||.:||.||||||||||:|.||:||.|:|.:.||||||||.
Frog   462 KAVKCESSIEQMCFIAAFSVSSYSTTVHRTAKPFNPLLGETFELDRLDDLGFRSICEQVSHHPPA 526

  Fly   508 AALHCESKN-WTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLW 571
            ||.:..||| |..|||.::.|||||||:.|.|||.::::|.:||..|.|||||:||:||||||||
Frog   527 AAHYVHSKNGWKLWQEITIASKFRGKYLSIMPLGDIHLEFHSSGNHYVWRKVTSTVHNIIVGKLW 591

  Fly   572 VDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAP 636
            :||.|::||...:..:  ||.|.|.||||||||:.|.|.|||.:.:.:..:|:.||||.|:|.|.
Frog   592 IDQSGDIEIINYKTKD--KCQLKFSPYSYFSRDIARKVTGVVTDANGKAHYVLSGTWDEKMECAK 654

  Fly   637 VLKTSGSVS------SPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLR 695
            ::::|...|      ...|.|...||.|::.|.|.:::..|.|:..|..|||.:|.|||||||.|
Frog   655 IVQSSHGNSCAEGKQKTVYQTLPPKLLWKKYPLPENAENMYFFSEFALTLNESDESVAPTDSRNR 719

  Fly   696 PDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEY 760
            |||||||.|.|||:|.||.|||||||..|||||.||.||..||..|..|:|:||:|:.:..:.|.
Frog   720 PDQRLMENGKWDEANVEKQRLEEKQRAVRRRREAEAVEALEEGNDYEGYQPLWFERKVDPYTGEL 784

  Fly   761 VHVFKNTYWEAKAAQNFEGCPDIY 784
            :..:|..|||.|..|::..||||:
Frog   785 ICNYKGGYWECKERQDWSCCPDIF 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	63/91 (69%)
		PH_OSBP_ORP4	17..113	CDD:270101	69/95 (73%)
		Oxysterol_BP	399..764	CDD:279564	208/371 (56%)
osbp2	XP_002931752.2	PH_OSBP_ORP4	71..166	CDD:270101	69/95 (73%)
osbp2	XP_002931752.2	Oxysterol_BP	418..794	CDD:366530	210/377 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	429	1.000	Domainoid score	I593
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75303
Inparanoid	1	1.050	698	1.000	Inparanoid score	I662
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D215020at33208
OrthoFinder	1	1.000	-	-		FOG0002531
OrthoInspector	1	1.000	-	-		otm48156
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060