DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and osbp

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_031761217.1	Gene:	osbp / 100488223	XenbaseID:	XB-GENE-6065172	Length:	784	Species:	Xenopus tropicalis

Alignment Length:	795	Identity:	380/795 - (47%)
Similarity:	491/795 - (61%)	Gaps:	112/795 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVISNGGT 82
            :|||.|||||||||||||||||.|:|||||:::|:.|||||||:|..|.|...|||.|||||||.
Frog    74 EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANISVEDSCNFVISNGGA 138

  Fly    83 QTFHIKAGTEVERQSWVTALELAKAKAIR-AIECEEEEETETAHVVPSQEISSVVRDLTDRLESM 146
            ||:|:||.:|||||.|:||||||||:|:: ..|.::..:.:.:......|:.|.:|.|:.::|.:
Frog   139 QTYHLKASSEVERQRWITALELAKARAVKMQAESDDSGDEDPSSQTDKAEVHSTLRALSGKVEDL 203

  Fly   147 RTCYDLITKHGAALQRALNDLETNE--EESLGSRTKIVNERATLFRITSNAMINAGNDYLHTAEA 209
            .||.|||.|||.||||:|::||:..  :|| ..:.|.||||||||||||||||||..|::..||:
Frog   204 GTCNDLIAKHGTALQRSLSELESLRLPQES-SEKIKQVNERATLFRITSNAMINACRDFMSLAES 267

  Fly   210 QGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPVSSTSGAGTA--------GS 266
            ...:|.:.|.:||:||.||||.:||:|||.:.:|:|   .|....:.|.:..|.:        |.
Frog   268 HSKRWQRALQYERDQRLRLEETLEQLAKQHNHLERA---FRGATVLPSVTRTGISKDPCVTGKGD 329

  Fly   267 LVTSDEEMEFFDAEE-----------HGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHL 320
            |...|::.|||||.|           |..|||..|..|.|      |::.|.|.:|.
Frog   330 LSDEDDDNEFFDAPEIISSPSQDGLGHKRSGSNISAASCD------IMEEHVRPTSE-------- 380

  Fly   321 EGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKK 385
                                                                        ||.|:
Frog   381 ------------------------------------------------------------DLRKE 385

  Fly   386 RRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDE 450
            ||.|:|.|||:.::||.:|||||||:|||||||:||||||||||||.||.||..:||..|.|:..
Frog   386 RRTRIPYKPNYSLNLWSVMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHTLLDRGAQCESA 450

  Fly   451 CEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESK 515
            .|||..:||||||:|:||..||.||||||||||:|.|||::.|:|.|.||||||||.||.|.||:
Frog   451 LEQLCLVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRMEESGYRSLCEQVSHHPPAAAHHAESR 515

  Fly   516 N-WTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEME 579
            : ||..||.::||||||||:.|.|||.::..|.|||..|:|:||||||:||||||||:||.||::
Frog   516 HGWTLRQEITVTSKFRGKYLSIMPLGTIHCVFHNSGNHYTWKKVTTTVHNIIVGKLWIDQSGEID 580

  Fly   580 IRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSV 644
            |...:.  |.:|.|.|.|||||||||.|.|.|.||:....|.:.:.||||.::|..||.    ||
Frog   581 IVNHKT--GDRCKLKFAPYSYFSRDVARKVSGEVMDATGRVHYTLMGTWDERMECIPVY----SV 639

  Fly   645 SSPTYTTGEFK-----LAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLRPDQRLMEQG 704
            |:.:...|:..     |.|:|.|.|.:::..|.||..|..||..|||.||:|||.||||||||.|
Frog   640 STVSENGGDKAADNKILLWKRNPLPKNAEYMYYFTEFALTLNAPEEGTAPSDSRHRPDQRLMENG 704

  Fly   705 DWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYW 769
            :|||:|.||.|||||||..|::||.|.|.|..:|.|...|:||||:|:.:..|:|..|:.:..||
Frog   705 NWDEANSEKQRLEEKQRNTRKKREAERERAGEDGSPVDTYKPMWFERKMDPVSKEMTHICRGIYW 769

  Fly   770 EAKAAQNFEGCPDIY 784
            |.|..|::..||||:
Frog   770 ECKERQDWASCPDIF 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	64/88 (73%)
		PH_OSBP_ORP4	17..113	CDD:270101	67/95 (71%)
		Oxysterol_BP	399..764	CDD:279564	209/370 (56%)
osbp	XP_031761217.1	PH_OSBP_ORP4	73..171	CDD:270101	67/96 (70%)
osbp	XP_031761217.1	Oxysterol_BP	399..770	CDD:395990	210/376 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	429	1.000	Domainoid score	I593
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I662
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D215020at33208
OrthoFinder	1	1.000	-	-		FOG0002531
OrthoInspector	1	1.000	-	-		otm48156
Panther	1	1.100	-	-	O	PTHR10972
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190