Protein Alignment Osbp and osbpl3

DIOPT Version :10

• Sequence 1: NP_477271.1
• Gene: Osbp / 42985
• FlyBaseID: FBgn0020626
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_012819861.2
• Gene: osbpl3 / 100379686
• XenbaseID: XB-GENE-950902
• Length: 912
• Species: Xenopus tropicalis
• Alignment Length: 883
• Identity: 251/883 - (28%)
• Similarity: 406/883 - (45%)
• Gaps: 197/883 - (22%)

  Fly    15 PE-MKGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGAL-----IHTV 70
            || .:|:||   ||.  :||:.:|:|.|.||:|.|.::|:::.   ||  .|||.:     :.:|
 Frog   114 PEKQEGFLLKKRKWP--LKGWHKRYFFLDKGILKYSKSQADME---RG--KLHGCIDVGLSVMSV 171

  Fly    71 DSCTFVIS-NGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECE----------------EE 118
            ...|..|. :.....:|:|.......:.||  |:|...:..|..|..                .|
 Frog   172 KKSTKCIDLDTEEHIYHLKVKFPEVFEEWV--LKLRDHRLYRQNEISVFPHDLNAPFFPMISTTE 234

  Fly   119 EETETAHVVPSQEISSVVRDLTDRLESMR-------TCYDLITKHGAALQRALNDLETNEEE--- 173
            ..:.....|||.:      |. :|..|::       :|.:..|:..|.||.: :::|...:|
 Frog   235 SASSAFDTVPSPQ------DF-NRKNSLKLGNNLPFSCLNNETRVPAWLQSS-DEMEICAKELSQ 291

  Fly   174 ---SLGSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQM 235
               .:...:.::.....|.|..|...|||    :.....:..|..|.:|..:.:.:.|    .:.
 Frog   292 CHSYIVEMSNLLQNMEVLHRTYSAPSINA----IQIGTIESPKKEKGIHRRKWRSKGL----NKD 348

  Fly   236 AKQQSQMEQAAVLVRQNKPVSSTSGAGTAGSLVTSDEEMEFFD-AEEHGYSGSGRSPE-----SS 294
            :|...|:..|...|.:               |..|:..:...| |||..|||...:.|     .|
 Frog   349 SKGSLQVPSAFSGVMR---------------LHASNPNLSTIDYAEEKQYSGGSENSEVTKMQDS 398

  Fly   295 DC---ERGTFILK-MHKRRSSSEDQVEGHLEGSSSES----------------DEQKRTVQTV-- 337
            .|   .:..|.|| .:....|..::::..||..||.|                :|.|..|..:
 Frog   399 LCHIANKAYFSLKSAYNTVFSEREKLKQFLEHDSSPSAPIAGLKNALSSDSPCEEGKTLVHQMSN 463

  Fly   338 ----------------QQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKR 386
                            |:|.|.|:   :|..:..|||..     ..:.:|::...|.:.|:..:|
 Frog   464 ESRLSITDSLTEFYDAQEVLLSSS---SSENEVSDDDSY-----VSDISDNVSEDNLSNDIDSER 520

  Fly   387 ---------------RDRV------PDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQR 430
                           :.|.      |:..|  ||||.|::|.||||||::.||:..|||||.|||
 Frog   521 LSLNGGSVTTVDGCYKHRTCLLAPCPNTSN--ISLWNILRNNIGKDLSRVSMPVQLNEPLSTLQR 583

  Fly   431 LVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTG-KPFNPLLGETYECDRMDDYGW 494
            |.|:.||:.:||.||...|..|::.|:|.|.|||||::..|.| |||||:||||||..: :|.|:
 Frog   584 LCEELEYSSLLDKAAHTPDPFERMVYVATFAVSAYASSFYRAGSKPFNPVLGETYEFIK-EDQGF 647

  Fly   495 RCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVT 559
            |.::||||||||::|.|.:|:|:..:|:....:||.||.::|..:|..::..|..|..|.|.|||
 Frog   648 RFISEQVSHHPPISACHADSENFVFFQDMRWKNKFWGKSMEIVQIGTTHLILPGFGDHYEWNKVT 712

  Fly   560 TTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVV 624
            :.::||:.|:.|::.:||:.|:.:::...| |.:.|:...|::.:| ..::|.||:::.:|...:
 Frog   713 SCIHNILSGQRWIEHYGEIIIKNTKSDTCH-CKVTFVKAKYWNPNV-HEIEGTVMDRNGKVVHRI 775

  Fly   625 RGTWDMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGV-- 687
            .|.|...|       ..||.|:||       ..||..|.|.||:.:|.||..|.||||.:..:
 Frog   776 FGKWHESI-------LYGSPSAPT-------CIWRANPMPKDSELYYGFTKYAFQLNEMDPKIKF 826

  Fly   688 -AP-TDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRR--RENEAEEAAAEGRPYPAYEPMW 748
             .| ||:|.|||||.:|:|:.:.:..:|.|:|:.|| |||:  .||..|           ::|.:
 Frog   827 SLPCTDTRFRPDQRYLEEGNIEAAEMQKERIEQLQR-ERRKVLEENNLE-----------HQPRF 879

  Fly   749 FKREKEEGSEEYVHVFKNTYWEAKAAQNFE--GCPDIY 784
            |::..::.     .|...|||:.:....|.  .||.::
 Frog   880 FRKTSDDS-----WVTNGTYWQLRKDPGFAKIDCPVLW 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH_OSBP_ORP4	17..113	CDD:270101	30/104 (29%)
		Oxysterol_BP	399..773	CDD:460126	147/380 (39%)
osbpl3	XP_012819861.2	PH_ORP3_ORP6_ORP7	96..216	CDD:270104	33/110 (30%)
		Oxysterol_BP	552..899	CDD:460126	147/380 (39%)