DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Osbp and osbpl6

DIOPT Version :9

Sequence 1:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_005172564.1	Gene:	osbpl6 / 100004342	ZFINID:	ZDB-GENE-070912-206	Length:	922	Species:	Danio rerio

Alignment Length:	938	Identity:	259/938 - (27%)
Similarity:	396/938 - (42%)	Gaps:	269/938 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PEM-KGWLL---KWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGAL--------- 66
            ||. :|::|   ||.  :||:.:|:|||..|:|.|.::..:|.   :|  .|||::
Zfish    70 PEKHEGFMLKKRKWP--LKGWHKRFFVLDNGILKYSKSPVDIQ---KG--KLHGSIDVGLSVMSI 127

  Fly    67 ------------------------IHTVDSC-----------------------TFVISNGGTQT 84
                                    :..:..|                       ||..|.|....
Zfish   128 KKRARRIDLDTEEHIYHLKVKSPDVFDLWVCKLRHHRLFRQNEIVRSPRDATLRTFPPSAGAESP 192

  Fly    85 FHIKAGTEVERQS------WVTALELAKAKAIRAIECEEEEETETAHVVPSQEIS---SVVRDLT 140
            .:..:.|..::|.      |......:..::..|...:|.||.:..    ::|::   |.:.:|.
Zfish   193 QNTPSSTHPKKQGKPSSFPWQLPPSCSNGQSKVAAWLQESEEMDKC----AEELAYCQSSLLELN 253

  Fly   141 DRLESM----RT------------CYDLITKH--------------GAALQRALNDLETNEEESL 175
            ..|:|:    ||            |.||..|.              .|.||:.:..|..:....:
Zfish   254 QLLQSLEILQRTQSAPNFTDMQSNCVDLSKKEKRVSRRWRTKSVSKDAKLQQQVQSLPQSHSAKV 318

  Fly   176 ------------GSRTKIVNE----RATLFRITSNAMINAGNDYLHTAE-----AQG-HKWSK-- 216
                        .|...:..|    :|.:.|:|..  |::..||:...|     ||. |...|
Zfish   319 PLSASMSQVRLHSSNPNLCAELADFQAPVTRLTDG--IDSAGDYIKLQEDFCIIAQKVHSLLKSA 381

  Fly   217 --------------MLHHER--------EQRQRLEEIIEQMAKQQSQMEQ---AAVLVRQNKPVS 256
                          :|.||:        ..|:.|.:.:.|.|:.::::.:   .:||..|...|:
Zfish   382 FNTVAIEKEKIKQVLLDHEQTGQSNQIVTLRRSLSQALSQNAELKTRLNRIHSESVLSEQVVSVN 446

  Fly   257 STSGAGTA-----------------GSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFILK 304
            ..|....|                 ..|..|:...|||||:|...|.|....|:||
Zfish   447 IISSPDEACEPLHVGLPLSQQVSNESRLSMSESVSEFFDAQEVLLSASSSENEASD--------- 502

  Fly   305 MHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKES 369
                       .|.::...|....|...:|                      .|:|.:.:|..|.
Zfish   503 -----------DESYVSDVSDNISEDNASV----------------------TDNVSRQMPNGEL 534

  Fly   370 TDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVED 434
            ..|::.....|.|...    .||..|  |:||.|:||.|||||||:.||:..||||:.||.:.|:
Zfish   535 ASSMFRNGRRPCLPAP----APDTSN--INLWNILKNNIGKDLSKVSMPVELNEPLNTLQHMCEE 593

  Fly   435 YEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTG-KPFNPLLGETYECDRMDDYGWRCLA 498
            .||||:||.||...|..|::|.:|||.||.|::|..|.| |||||||||||||.| :|.|:...:
Zfish   594 LEYTELLDKAAQTDDPYERMAIVAAFAVSGYSSTYYRAGSKPFNPLLGETYECIR-EDKGFCFFS 657

  Fly   499 EQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVN 563
            ||||||||::|.||:|:|:|.||:....:||.||.::|.|:|.|.|..|:.|..|.|.||||.|:
Zfish   658 EQVSHHPPISACHCDSQNFTFWQDVRWKNKFWGKSMEILPIGTVNVMLPSYGDHYEWNKVTTCVH 722

  Fly   564 NIIVGKLWVDQHGEMEIRGSQAAEGHKCI--LNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRG 626
            ||:.|:.|::.:||:.||.:::.   .||  |:||..:|:|.:| ..|:|.||:::..|...:.|
Zfish   723 NILSGRRWIEHYGEVTIRNTRST---TCICKLSFIKGNYWSSNV-NEVQGSVMDQEGRVIHRLFG 783

  Fly   627 TW--DMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLN----EEEE 685
            .|  .:...:.|                ..|..||....|.|.:.:|.||..|.:||    |.:|
Zfish   784 KWHEGLYCGVPP----------------SAKCIWRPGSMPTDYELYYGFTRFAVELNELFPEMKE 832

  Fly   686 GVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERR-RRENEAEEAAAEGRPYPAYEPMWF 749
            .:.|||:|.|||||.:|:|:...:..||.|:||:||..|: ..||..:           ::|.:|
Zfish   833 LLPPTDARFRPDQRFLEEGNVQMATAEKQRIEEQQRNRRKWMEENNIK-----------HQPRFF 886

  Fly   750 KREKEEGSEEYVHVFKNTYWEAKAAQNF 777
            |:..:....|. .|..:.|||.:....|
Zfish   887 KKVMDSNQRER-WVSNSMYWELRKDPGF 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Osbp	NP_477271.1	PH	15..107	CDD:278594	28/157 (18%)
		PH_OSBP_ORP4	17..113	CDD:270101	26/161 (16%)
		Oxysterol_BP	399..764	CDD:279564	153/374 (41%)
osbpl6	XP_005172564.1	PH_ORP3_ORP6_ORP7	50..172	CDD:270104	21/108 (19%)
		PH	72..157	CDD:278594	18/91 (20%)
		Oxysterol_BP	558..899	CDD:279564	153/373 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542090at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920